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HMOX1 — PPARA

Text-mined interactions from Literome

Krönke et al., Arterioscler Thromb Vasc Biol 2007 : Here we investigate if the vasculoprotective and anti-inflammatory enzyme heme oxygenase-1 (HO-1) is regulated by PPAR ligands in vascular cells ... Analysis of the human HO-1 promoter in transient transfection experiments together with mutational analysis and gel shift assays revealed a direct transcriptional regulation of HO-1 by PPARalpha and PPARgamma via 2 PPAR responsive elements ... We demonstrate that HO-1 expression is transcriptionally regulated by PPARalpha and PPARgamma, indicating a mechanism of anti-inflammatory and antiproliferative action of PPAR ligands via upregulation of HO-1
Lin et al., Am J Pathol 2010 (Drug-Induced Liver Injury...) : Additionally, we revealed direct transcriptional regulation of HO-1 by the binding of PPARa to a PPAR-responsive element (PPRE) by various experimental assessments
Burgess et al., Hypertension 2010 (Metabolic Syndrome X...) : HO-1 induction increased adiponectin, pAKT, pAMPK, and PPAR? levels in adipocyte of obese animals
von Knethen et al., Free Radic Biol Med 2011 : NADPH oxidase activation in either RAW264.7 cells or peritoneal macrophages ( PM ) derived from PPAR? wild-type mice increased reactive oxygen species ( ROS ) formation, caused PPAR? activation, heme oxygenase-1 (HO-1) induction , and concomitant IFN-ß expression
Yang et al., World J Gastroenterol 2012 (Liver Cirrhosis) : To investigate the effects of heme oxygenase (HO)-1 on liver fibrosis and the expression of peroxisome proliferator activated receptor gamma ( PPAR? ) and nuclear factor-kappa B ( NF-?B ) in rats
Liu et al., Arthritis Res Ther 2012 : Our results suggest that the interaction between thrombin and PAR1/PAR3 increases HO-1 expression in human synovial fibroblasts through the PKCd, c-Src, and Nrf2 signaling pathways