Mitsiades et al., Oncogene 2002
(Multiple Myeloma) :
In contrast, IL-6 does not cause sustained NF-kappaB activation, induces less pronounced Akt activation and FKHRL-1 phosphorylation than IGF-1, and increases the expression of only survivin
Pene et al., Oncogene 2002
(Multiple Myeloma) :
IGF-1 but not IL-6 increased phosphorylation of Akt, FKHRL-1 and P70 ( S6K )
Dejean et al., Nat Immunol 2009
(Arenaviridae Infections) :
Stimulation of dendritic cells mediated by the coinhibitory molecule CTLA-4 induced nuclear localization of Foxo3 , which in turn inhibited the production of interleukin 6 and tumor necrosis factor