Gene interactions and pathways from curated databases and text-mining

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CTNNB1 — MAPK11

Pathways - manually collected, often from reviews:

  • Reactome Reaction: MAPK11 → CTNNB1 (indirect_complex)
  • Reactome Reaction: MAPK11 → CTNNB1 (reaction)

Text-mined interactions from Literome

Schohl et al., Development 2002 (MAP Kinase Signaling System) : We found that the patterns of P-MAPK , P-Smad1 and P-Smad2 are indeed strongly dependent on beta-catenin at this stage
Bikkavilli et al., J Cell Sci 2008 : Activation of p38 MAPK is critical for canonical Wnt-beta-catenin signaling ... Chemical inhibitors of p38 MAPK ( SB203580 or SB239063 ) and expression of a dominant negative-version of p38 MAPK attenuate Wnt3a induced accumulation of beta-catenin , Lef/Tcf-sensitive gene activation, and primitive endoderm formation
Jeong et al., Cell cycle (Georgetown, Tex.) 2009 : In addition, PPARdelta increased protein kinase C ( PKC ), cytosolic phospholipase A ( 2 ) ( cPLA(2) ) and p38 mitogen activated protein kinase ( p38 MAPK ) phosphorylation, and Wnt/beta-catenin activation
Kim et al., Pigment Cell Melanoma Res 2010 : In addition, phosphorylation of p38 MAPK was significantly reduced by beta-catenin , potentiating its inhibitory role for dendrite formation