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BCL2 — VEGFA

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: BCL2 → VEGFA (increases)
  Evidence: longer term effects of VEGF on cell survival may be mediated through the upregulation of the antiapoptotic proteins BCL2 and A1

Text-mined interactions from Literome

Nör et al., J Vasc Res 2000 : TSP1 also attenuated VEGF mediated Bcl-2 expression in endothelial cells in vitro and angiogenesis in vivo
Pidgeon et al., Br J Cancer 2001 (Adenocarcinoma...) : In both murine ( 4T1 ) and human ( MDA-MB-231 ) metastatic mammary carcinoma cell lines, we found that VEGF upregulated Bcl-2 expression and anti-VEGF antibodies reduced Bcl-2 expression
Beierle et al., J Pediatr Surg 2002 (Neuroblastoma) : VEGF upregulates Bcl-2 expression and is associated with decreased apoptosis in neuroblastoma cells ... The authors hypothesize that VEGF upregulates Bcl-2 expression by the neuroblastoma cells and protects them from apoptotic stimuli ... To determine whether VEGF will induce Bcl-2 expression in neuroblastoma cells, the cells are plated with standard media ( control ) or media supplemented with VEGF ... VEGF increases Bcl-2 expression by 33 % over cells cultured in standard media ... VEGF increases the expression of Bcl-2 and also abrogates TNF-alpha and serum starvation induced apoptosis in neuroblastoma cells in vitro
Dias et al., Blood 2002 (Leukemia...) : Similar to endothelial cells ( ECs ), vascular endothelial growth factor ( VEGF ) induces Bcl-2 expression on VEGF receptor positive ( VEGFR ( + ) ) primary leukemias and cell lines, promoting survival ... In turn, Hsp90 modulated Bcl-2 expression, as shown by a complete blockage of VEGF induced Bcl-2 expression and binding to Hsp90 by the Hsp90-specific inhibitor geldanamycin ( GA )
Cai et al., Diabetes 2003 (Neovascularization, Pathologic) : In contrast, VEGF induced tube formations and Bcl-2 expression were significantly decreased at the end of this period
Wang et al., Leukemia 2005 (Burkitt Lymphoma...) : VEGF induced phosphorylation of Bcl-2 influences B lineage leukemic cell response to apoptotic stimuli
Liang et al., Endocr Relat Cancer 2006 : Furthermore, VEGF induced the expression of the anti-apoptotic protein Bcl-2 and blocked down-regulation of Bcl-2 by ICI 182,780 and induced Bcl-2 in BT-474 and T47-D cells even in the presence of RU-486 ... Increased Bcl-2 levels in response to VEGF were associated with increased proliferation and survival of tumor cells even in the presence of anti-hormones
Kim et al., J Immunol 2006 (Arthritis, Rheumatoid...) : VEGF165 rapidly triggered phospho-Akt and phospho-ERK activity and then induced Bcl-2 expression in the rheumatoid synoviocytes
Liao et al., Zhongguo Dang Dai Er Ke Za Zhi 2006 (Leukemia) : [ Effect of vascular endothelial growth factor on apoptosis and expression of Bcl-2 and Mcl-1 in acute leukemia cells ]
Karl et al., Cell Death Differ 2007 : Inhibition of VEGF receptor signaling in HDMEC-Bcl-x ( L ) prevented Bcl-2 upregulation and demonstrated the function of a VEGF mediated autocrine loop
Kosaka et al., Biochem Biophys Res Commun 2007 : VEGF did not stimulate or inhibit Bcl-xL and Bax, respectively, in granulosa cells
Kaneko et al., Cancer Res 2007 (Carcinoma, Squamous Cell...) : Bcl-2 induces vascular endothelial growth factor ( VEGF ) expression in neovascular endothelial cells through a signal transducer and activator of transcription 3 ( STAT3 ) -mediated pathway ... Endothelial cell derived VEGF signals through VEGFR1 and induces expression of Bcl-2 and the proangiogenic chemokines CXCL1 and CXCL8 in HNSCC cells
Anai et al., Urology 2007 (Prostatic Neoplasms) : Downregulation of BCL-2 induces downregulation of carbonic anhydrase IX, vascular endothelial growth factor , and pAkt and induces radiation sensitization
Tolosa et al., J Neurochem 2008 : VEGF also prevented the down-regulation of Bcl-2 and survivin, two proteins implicated in anti-apoptotic and/or anti-excitotoxic effects, after THA exposure
Chen et al., Cancer Biol Ther 2008 (Neoplasms...) : Activated STAT3 mediated VEGF induction of EC Bcl-2 and contributed to VEGF protection of EC from apoptosis
Tolosa et al., Neuroscience 2009 : In addition, serum deprivation induced down-regulation of the anti-apoptotic protein Bcl-2 and this effect was prevented both by SB203580 and by VEGF via the PI3-K/Akt pathway
Wang et al., Cell Mol Neurobiol 2009 (MAP Kinase Signaling System...) : Furthermore, rhVEGF ( 165 ) was utilized to discern that VEGF increased Bcl-2 and procaspase 3 expressions, contributing to a synergistic relationship of an angiogenic response with Bcl-2 in hypoxia via a cross talk, while the activation of ERK MAPK is important for both productions
Sakai et al., World J Urol 2009 (Prostatic Neoplasms) : VEGF induces expression of Bcl-2 and multiple signaling factors in microvascular endothelial cells in a prostate cancer model ... VEGF stimulation increased Bcl-2 expression in human microvascular endothelial cells ( HMVECs ), at least partially through stabilization of Bcl-2 mRNA transcripts, and protected these cells from apoptosis
Sanchez et al., Neuropeptides 2010 : VEGF decreases active caspase 3 levels and increases expression of the anti-apoptotic protein Bcl-2
Horiguchi et al., Br J Cancer 2010 (Carcinoma, Renal Cell...) : WP1066 suppressed the expression of Bcl-2 , induced apoptosis, and inhibited the basal and hypoxia induced expression of HIF1alpha and HIF2alpha, as well as vascular endothelial growth factor secretion into cell culture medium
Tarquinio et al., J Oral Pathol Med 2012 (Carcinoma, Squamous Cell...) : In vitro, mechanistic studies were performed to examine the effect of vascular endothelial growth factor ( VEGF ) -C on the expression of Bcl-2 in primary human lymphatic endothelial cells
Ratajczak et al., Mod Pathol 2012 (Disease Progression...) : In squamous cell carcinoma, endothelial BCL2 expression induces a crosstalk with tumor cells through VEGFA , a major mediator of tumoral angiogenesis
Penna et al., J Cell Mol Med 2013 : Only FN-PAM-VEGF significantly increased Bcl-2 levels
Neelam et al., Molecular vision 2013 (MAP Kinase Signaling System) : Axitinib, which inhibits lenticular cell autophosphorylation of its VEGF receptor, was employed to demonstrate a role for the VEGF-VEGFR2 receptor complex in regulating Bcl-2 expression ... Axitinib also prevented the VEGF mediated expression of Bcl-2