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FUT1 — INS
Text-mined interactions from Literome
Svegliati-Baroni et al., Hepatology 1999
(Liver Cirrhosis) :
Insulin and IGF-1
induced 70-kd S6 kinase phosphorylation in
HSC , whereas IGF-1 only induced ERK phosphorylation
Di Sario et al., J Hepatol 2001
:
Amiloride ( 100 micromol/l ) and 20 micromol/l 5-N-ethyl-N-isopropyl-amiloride completely inhibited HSC proliferation ( evaluated by measurement of bromodeoxyuridine incorporation ) induced by PDGF and IGF-1, but did not affect proliferation of
HSC induced by
insulin
Chen et al., J Endocrinol 2006
(Diabetes Mellitus, Experimental) :
Downregulation of the constitutively expressed
Hsc70 in diabetic myocardium is
mediated by
insulin deficiency ... In cultured cardiomyocytes, insulin directly increased the abundance of Hsc70, whereas insulin could not modulate Hsp70. Treating diabetic rats with
insulin restored myocardial
Hsc70 level, but phlorizin treatment failed to restore myocardial Hsc70
Biol et al., Biochim Biophys Acta 1992
:
Thyroxine and
insulin , injected into suckling rats, did not
induce significant modifications of the
fucosyl-transferase activity, under the conditions used, whereas this enzyme activity was highly enhanced after administration of glucocorticoids ( cortisone and hydrocortisone )
Lin et al., Lab Invest 2009
(Hyperinsulinism) :
Elevated levels of
insulin stimulate
HSC activation ... This study aims at evaluating the effect of curcumin on
insulin induced
HSC activation and further elucidating the underlying mechanisms ... We report that curcumin dose-dependently eliminates
insulin induced
HSC activation by suppressing expression of type I collagen gene and other key genes relevant to HSC activation ... Our results provide novel insights into the mechanisms by which curcumin inhibits the
insulin induced
HSC activation
de la Rosa et al., Proc Natl Acad Sci U S A 1998
:
While characterizing the molecules involved in this survival effect of insulin, we found
insulin dependent regulation of the molecular chaperone
heat shock cognate 70 kDa (Hsc70) , whose cloning in chicken is reported here
Biol et al., Am J Physiol 1998
:
Insulin treatment of young suckling rats
induced a precocious increase in
fucosyltransferase activity and in the biosynthesis of its substrate ( GDP-fucose ), but the sensitivity to insulin disappeared after weaning