Gene interactions and pathways from curated databases and text-mining

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INS — NGF

Text-mined interactions from Literome

Hiriart et al., Isr Med Assoc J 2001 : Moreover, both NGF and FGF enhance glucose induced insulin secretion
Rosenbaum et al., Diabetes 2001 : We analyzed the effect of endogenous NGF on insulin secretion by incubating islet cells in the presence of an anti-NGF monoclonal antibody for 1 h in different glucose concentrations ... These results suggest that the effects of NGF on insulin secretion are partially mediated by an increase in calcium current through Ca channels
Vidaltamayo et al., FASEB J 2002 : These data suggest that NGF could preserve an adequate expression of sodium channels and that impairment of NGF modulation could lead to deficient insulin secretion and diabetes mellitus
Bhat et al., J Alzheimers Dis 2002 : To determine whether these pathways interact from a signalling perspective, we compared the effects of BAF ( a general caspase inhibitor ), Li+ ( a GSK3beta inhibitor ) and insulin on NGF-W induced PC12 cell death
Schreiber et al., J Pediatr Endocrinol 2005 (Hereditary Sensory and Autonomic Neuropathies...) : We hypothesized that CIPA may represent a natural model for impaired NGF effect on insulin secretion in humans ... Additional studies on the clinical significance of NGF-TrkA effects on insulin secretion are required
Navarro-Tableros et al., Channels (Austin) 2007 : NGF increases glucose induced insulin secretion by modulating electrical activity in adult beta cells
Li et al., Theriogenology 2010 : Using an immunofluorescent technique, NGF-immunoreactivity was localized to the sperm head and tail, whereas that of TrkA was detected in the acrosomal cap, nucleus, and tail regions When sperm were treated with exogenous NGF, both leptin secretion and sperm viability were increased ( P < 0.05 ) ; moreover, the percentages of late apoptotic and dead sperm were increased ( P < 0.05 ). However, NGF had no effects on insulin secretion, mitochondrial activity, intracellular calcium levels, or the acrosome reaction of sperm ( P > 0.05 )
Vidaltamayo et al., Endocrine 1996 : We studied the effects of nerve growth factor (NGF), fibroblast growth factor ( FGF ), and dibutyryl-cAMP ( dbcAMP ) on rat pancreatic ß-cell morphology and of NGF and dbcAMP on insulin secretion
Sadovnikova et al., Biull Eksp Biol Med 1988 : The effects of fibroblast growth factor ( FGF ) and nerve growth factor (NGF) on DNA synthesis and insulin secretion were studied in 4-5-day cultures of the isolated neonatal rat islets
Schubert et al., Brain Res 1980 : Insulin does not, however, alter the morphology of the cells, nor does it block the morphological response of the cells to nerve growth factor
González-Hernández et al., Rev Esp Fisiol 1993 : Insulin and TGF-beta caused an enhancement of beta-NGF and c-myc RNA expression
Sher et al., Eur J Cell Biol 1995 (Insulinoma...) : We also demonstrate that NGF increases the expression of insulin and that SgII and insulin are predominantly, but not always, colocalized
Ohmichi et al., J Biol Chem 1994 : NGF and EGF also induced the association of Shc proteins with a Grb2 fusion protein or endogenous Grb2, whereas insulin had no effect
Ang et al., Brain Res Dev Brain Res 1993 : Insulin , IGF-I or NGF in the absence of astrocytes did not greatly increase the neurite growth
Aoyagi et al., Biol Neonate 1997 : The presence of NGF ( 100 ng/ml ) during the initial 2-day culture period increased the insulin release in the presence of 15 mmol/l glucose and theophylline during the subsequent 24-hour culture period as compared to cells cultured in the absence of NGF