Nagamatsu et al., Diabetes 1999
(Diabetes Mellitus, Type 2) :
Decreased expression of t-SNARE , syntaxin 1, and SNAP-25 in pancreatic beta-cells is involved in impaired insulin secretion from diabetic GK rat islets : restoration of decreased t-SNARE proteins improves impaired insulin secretion
Nevins et al., J Biol Chem 2005
:
A direct interaction between Cdc42 and vesicle associated membrane protein 2 regulates SNARE dependent insulin exocytosis
Dai et al., Diabetologia 2012
:
This demonstrates that native Kv2.1-syntaxin 1A interaction plays a key role in human insulin secretion, which is separate from the channel 's electrical function
Nagamatsu et al., J Biol Chem 1996
:
Glucose unstimulated insulin release and the proinsulin biosynthetic rate were not affected by syntaxin 1A overexpression, indicating a specific role of syntaxin 1A in the regulatory insulin release pathway