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MATK — TP53

Text-mined interactions from Literome

Gottifredi et al., Mol Cell Biol 2001 : It was therefore of interest to determine whether reciprocally, p53 affects either CHK1 or CHK2
Jack et al., Proc Natl Acad Sci U S A 2002 : We conclude that Chk2 is not involved in Atm- and p53 dependent G ( 1 ) arrest, but is involved in the activation of latent p53 , independently of Atm, in triggering DNA damage induced apoptosis
Wang et al., J Biol Chem 2004 (Ovarian Neoplasms) : In addition, it was shown that NBS1, SMC1, and p53 were phosphorylated in an ATM dependent manner, and p53 phosphorylation on serine 20 is dependent on CHK2 after irofulven treatment
Ho et al., Cancer Res 2006 : Down-regulation of CHK1 or CHK2, however, reduced p53 basal expression but not the hydroxyurea dependent induction
Wang et al., Biochem Pharmacol 2007 (Chromosome Aberrations) : However, whether p53 affects CHK2 activation and whether CHK2 activation modulates chemosensitivity are unclear
Craig et al., Mol Cell Biol 2007 : Evaluation of these calcium calmodulin kinase superfamily members as candidate Ser ( 20 ) kinases in vivo has shown that only CHK1 or DAPK-1 can stimulate p53 transactivation and induce Ser ( 20 ) phosphorylation of p53
Zaugg et al., Proc Natl Acad Sci U S A 2007 (Neoplasms) : Strikingly, loss of Chk1 activated the checkpoint kinase Chk2 as well as the tumor suppressor p53 in these thymocytes
Vitale et al., PloS one 2007 (Polyploidy) : Altogether, our results demonstrate that, in tetraploid tumor cells, the inhibition of Chk1 sequentially triggers aberrant mitosis, p53 activation and Puma/BBC3 dependent mitochondrial apoptosis
Hastak et al., Proc Natl Acad Sci U S A 2008 : DNA synthesis from unbalanced nucleotide pools causes limited DNA damage that triggers ATR-CHK1 dependent p53 activation
Habib et al., Arch Biochem Biophys 2009 (MAP Kinase Signaling System) : Down-regulation of ATM and Chk2 by their small interfering RNAs ( siRNAs ) attenuated the arsenite induced phosphorylation of p53 and restored Hsp90beta mRNA levels
Bailly et al., PLoS Genet 2010 (Genomic Instability) : GEN-1 promotes germ cell cycle arrest and apoptosis via a pathway that acts in parallel to the canonical DNA damage response pathway mediated by RPA loading, CHK1 activation , and CEP-1/p53 mediated apoptosis induction
Niida et al., EMBO J 2010 (Chromosome Aberrations...) : Neither Chk1 nor Chk2 is apparently essential for p53- or Rb-dependent oncogene induced senescence
Du et al., PloS one 2013 (Ovarian Neoplasms) : The present studies demonstrate for the first time that SB225002 has dual actions in OVCA cells, inducing classic apoptosis through p53 activation and provoking mitotic catastrophe in both p53 wild-type and deficient cells by Chk1 inhibition and Cdk activation
Kalan et al., Frontiers in genetics 2013 : We found that depletion of Ajuba led to apparent delays in the cell cycle, accompanied with increased Rb phosphorylation, Chk1 phosphorylation, induction of p53 , and cell death
Flaggs et al., Curr Biol 1997 : The association of Chk1 with meiotic chromosomes and levels of Chk1 protein depend upon a functional Atm gene product, but Chk1 is not dependent upon p53 for meiosis I functions