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FOXP3 — SMAD3
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Yang et al., Immunity 2008
(Encephalomyelitis, Autoimmune, Experimental...) :
Although TGF-beta receptor I signaling was required for both Foxp3 and IL-17 induction,
SMAD4 was only
involved in
Foxp3 upregulation
Xiao et al., J Immunol 2008
(Autoimmune Diseases) :
Herein we show that RA enhances TGF-beta signaling by increasing the expression and phosphorylation of
Smad3 , and this
results in increased
Foxp3 expression even in the presence of IL-6 or IL-21
Yoshimura et al., Curr Top Microbiol Immunol 2011
:
On the one hand, little is known about molecular mechanisms involved in immune suppression via TGF-ß ; however, recent studies suggest that Smad2 as well as
Smad3 play essential roles in
Foxp3 induction and cytokine suppression, whereas Th17 differentiation is promoted via the Smad independent pathway
Schlenner et al., J Exp Med 2012
(Colitis) :
In vitro,
Smad signaling facilitates conversion of naive T cells into T reg cells but
results in unstable
Foxp3 expression