Gene interactions and pathways from curated databases and text-mining

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BCR — BLNK

Pathways - manually collected, often from reviews:

  • BioCarta bcr signaling pathway: B-cell antigen/BCR/CD79A/CD79B/Btk/LYN/BLNK complex (BCR-CD79A-CD79B-BTK-LYN-BLNK) → SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1) (modification, activates)
  • BioCarta bcr signaling pathway: LYN → B-cell antigen/BCR/CD79A/CD79B/Btk/LYN/BLNK complex (BCR-CD79A-CD79B-BTK-LYN-BLNK) (modification, collaborate)
  • BioCarta bcr signaling pathway: B-cell antigen/BCR/CD79A/CD79B/Btk/LYN/BLNK complex (BCR-CD79A-CD79B-BTK-LYN-BLNK) → BLNK (modification, collaborate)
  • BioCarta bcr signaling pathway: B-cell antigen/BCR/CD79A/CD79B/Btk/LYN/BLNK complex (BCR-CD79A-CD79B-BTK-LYN-BLNK) → BTK (modification, collaborate)
  • BioCarta bcr signaling pathway: B-cell antigen/BCR/CD79A/CD79B/Btk/LYN/BLNK complex (BCR-CD79A-CD79B-BTK-LYN-BLNK) → B-cell antigen/BCR complex complex (BCR-CD79A-CD79B) (modification, collaborate)
  • BioCarta bcr signaling pathway: BLNK → B-cell antigen/BCR complex complex (BCR-CD79A-CD79B) (modification, collaborate)

Text-mined interactions from Literome

Benschop et al., J Immunol 2001 : BCR induced tyrosine phosphorylation of CD79a, Lyn, B cell linker protein , and phospholipase Cgamma2 is enhanced in immature B cells and they exhibit greater capacitative calcium entry in response to Ag
Kövesdi et al., Cell Signal 2002 (Calcium Signaling) : Both BLNK and phospholipase C ( PLC ) gamma were raft associated in unstimulated pre-B cells, and this could not be enhanced by pre-BCR engagement, suggesting a ligand independent PLC gamma mediated signaling
Kabak et al., Mol Cell Biol 2002 : Moreover, ligation of the endogenous BCR induced Y204 phosphorylation and BLNK recruitment
Tsubata et al., Int Rev Immunol 2001 : BCR proximal signaling occurs within cholesterol- and sphingolipid-rich plasma membrane microdomains termed lipid rafts, and involves tyrosine kinases such as Lyn, Syk and Btk and the adapter molecule SLP65/BLNK
Hollmann et al., Leuk Res 2010 (Calcium Signaling...) : In particular, although Src family kinase phosphorylation was inhibited by 100-150 nM dasatinib in all cell lines, this failed to inhibit BCR mediated Blnk phosphorylation, calcium signaling and proliferation in a dasatinib resistant cell line
Zhang et al., EMBO J 1998 : By monitoring the activation of signaling elements in pervanadate stimulated B cells expressing different levels of the BCR, we show here that phosphorylation of SLP-65 and Syk, but not of Lyn, is strictly dependent on the expression of the BCR on the cell surface