◀ Back to BCR
BCR — BLNK
Pathways - manually collected, often from reviews:
-
BioCarta bcr signaling pathway:
B-cell antigen/BCR/CD79A/CD79B/Btk/LYN/BLNK complex (BCR-CD79A-CD79B-BTK-LYN-BLNK)
→
SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1)
(modification, activates)
-
BioCarta bcr signaling pathway:
LYN
→
B-cell antigen/BCR/CD79A/CD79B/Btk/LYN/BLNK complex (BCR-CD79A-CD79B-BTK-LYN-BLNK)
(modification, collaborate)
-
BioCarta bcr signaling pathway:
B-cell antigen/BCR/CD79A/CD79B/Btk/LYN/BLNK complex (BCR-CD79A-CD79B-BTK-LYN-BLNK)
→
BLNK
(modification, collaborate)
-
BioCarta bcr signaling pathway:
B-cell antigen/BCR/CD79A/CD79B/Btk/LYN/BLNK complex (BCR-CD79A-CD79B-BTK-LYN-BLNK)
→
BTK
(modification, collaborate)
-
BioCarta bcr signaling pathway:
B-cell antigen/BCR/CD79A/CD79B/Btk/LYN/BLNK complex (BCR-CD79A-CD79B-BTK-LYN-BLNK)
→
B-cell antigen/BCR complex complex (BCR-CD79A-CD79B)
(modification, collaborate)
-
BioCarta bcr signaling pathway:
BLNK
→
B-cell antigen/BCR complex complex (BCR-CD79A-CD79B)
(modification, collaborate)
Text-mined interactions from Literome
Benschop et al., J Immunol 2001
:
BCR induced tyrosine phosphorylation of CD79a, Lyn,
B cell linker protein , and phospholipase Cgamma2 is enhanced in immature B cells and they exhibit greater capacitative calcium entry in response to Ag
Kövesdi et al., Cell Signal 2002
(Calcium Signaling) :
Both
BLNK and phospholipase C ( PLC ) gamma were raft associated in unstimulated pre-B cells, and this could not be
enhanced by
pre-BCR engagement, suggesting a ligand independent PLC gamma mediated signaling
Kabak et al., Mol Cell Biol 2002
:
Moreover, ligation of the endogenous
BCR induced Y204 phosphorylation and
BLNK recruitment
Tsubata et al., Int Rev Immunol 2001
:
BCR proximal signaling occurs within cholesterol- and sphingolipid-rich plasma membrane microdomains termed lipid rafts, and
involves tyrosine kinases such as Lyn, Syk and Btk and the adapter molecule
SLP65/BLNK
Hollmann et al., Leuk Res 2010
(Calcium Signaling...) :
In particular, although Src family kinase phosphorylation was inhibited by 100-150 nM dasatinib in all cell lines, this failed to inhibit
BCR mediated
Blnk phosphorylation, calcium signaling and proliferation in a dasatinib resistant cell line
Zhang et al., EMBO J 1998
:
By monitoring the activation of signaling elements in pervanadate stimulated B cells expressing different levels of the BCR, we show here that phosphorylation of
SLP-65 and Syk, but not of Lyn, is strictly
dependent on the expression of the
BCR on the cell surface