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BCR — RAF1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Che et al., Circulation 2001
:
Overexpression of
Bcr also
enhanced PDGF induced
Ras/Raf-1 activity and DNA synthesis, but this regulation is independent of the kinase activity of Bcr
Abe et al., Ann N Y Acad Sci 2001
:
A dominant negative Ras did not inhibit Bcr kinase activation, and overexpression of
Bcr increased
Ras/Raf-1 activity and DNA synthesis
Yu et al., Blood 2003
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
These events were accompanied by down-regulation of the
Raf-1/mitogen induced extracellular kinase ( MEK ) /extracellular signal related kinase ( ERK ) pathway as well as diminished expression of
Bcr/Abl and cyclin D1, cleavage of p21CIP1 and phosphorylation of the retinoblastoma protein ( pRb ), and induction of the stress related kinases Jun kinase (JNK) and p38 mitogen activated protein kinase ( MAPK )
Skorski et al., Cancer Res 1995
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
We show that
c-RAF-1 enzymatic activity is
regulated by
BCR/ABL , although the protein does not associate with BCR/ABL