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CAPN7 — MMP2
Text-mined interactions from Literome
Li et al., Diabetes 2011
(Cardiomyopathy, Hypertrophic...) :
In cultured cardiac fibroblasts, high glucose induced proliferation and
MMP activities were
prevented by
calpain inhibition
Subramanian et al., J Cardiovasc Pharmacol 2012
(Aortic Aneurysm, Abdominal...) :
Inhibition of
calpain , a calcium activated neutral cysteine protease, by overexpression of its endogenous inhibitor, calpastatin,
attenuates AngII induced leukocyte infiltration, perivascular inflammation, and
MMP activation in mice
Singh et al., Can J Physiol Pharmacol 2012
(Anoxia...) :
On the other hand, inhibition of
calpain activity upon treatment with leupeptin or MDL 28170 significantly
reduced the
MMP activity in addition to attenuating the I/R induced alterations in cardiac function and Na ( + ) /K ( + ) -ATPase activity
Jiang et al., Hypertension 2012
(Calcinosis...) :
However, the
role of
calpain-1 in
MMP2 activation and extracellular matrix remodeling remains unknown
Liu et al., Reproductive biology and endocrinology : RB&E 2013
(Endometriosis) :
Western blotting, quantitative real-time PCR and zymography were carried out to detect the
effect of
CAPN 7 on the expressions and activity of
MMP-2 ...
CAPN 7 overexpression
led to increased expression of
MMP-2 and tissue inhibitor of metalloproteinases 2 ( TIMP-2 ) ; CAPN 7 knockdown reversed these changes ...
CAPN 7 increased
MMP-2 activity by increasing the ratio of MMP-2 to TIMP-2