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CDH1 — NFKB1
Text-mined interactions from Literome
Kuphal et al., Oncogene 2004
(Melanoma) :
Loss of
E-cadherin leads to upregulation of
NFkappaB activity in malignant melanoma ... Here, we show that loss of
E-cadherin leads to induction of
nuclear factor kappa B (NFkappaB) activity in melanoma cell lines ... In summary, we conclude that loss of
E-cadherin and cytoplasmatic beta-catenin
induces p38 mediated
NFkappaB activation, potentially revealing an important mechanism of tumorigenesis in malignant melanomas
Kuphal et al., Oncogene 2006
(Melanoma...) :
Loss of
E-cadherin induces
NFkappaB activity and N-cadherin expression in tumorigenic EMT
Chua et al., Oncogene 2007
(Cell Transformation, Neoplastic...) :
NF-kappaB represses
E-cadherin expression and enhances epithelial to mesenchymal transition of mammary epithelial cells : potential involvement of ZEB-1 and ZEB-2
Julien et al., Oncogene 2007
(Carcinoma, Squamous Cell...) :
Here, we show that Snail activation and consequent repression of
E-cadherin may depend on AKT mediated nuclear factor-kappaB (NF-kappaB) activation, and that
NF-kappaB induces Snail expression
Simiantonaki et al., Int J Oncol 2007
(Adenocarcinoma...) :
Considering the fact that cancer cell necrosis plays a crucial role in metastasis,
NFkappaB activation
mediated by loss of
E-cadherin may represent an essential, even initial event in this process
Criswell et al., J Biol Chem 2007
:
This loss of
E-cadherin was
due to increased
NFkappaB activity that, in turn, resulted in increased expression of the transcriptional repressors of E-cadherin such as Snail, Slug, Twist, and Sip1 ... These data indicate that TbetaRIII acts as a tumor suppressor in nontumorigenic mammary epithelial cells at least in part by inhibiting
NFkappaB mediated repression of
E-cadherin
Solanas et al., J Cell Sci 2008
:
E-cadherin controls beta-catenin and
NF-kappaB transcriptional activity in mesenchymal gene expression ...
E-cadherin overexpression decreased the transcriptional activity of the fibronectin promoter and
reduced the interaction of beta-catenin and
NF-kappaB with this promoter
Strippoli et al., Dis Model Mech 2008
:
Retroviral overexpression of a mutant inhibitor of kappaB ( IkappaB ) demonstrated that
NF-kappaB activation is
required for
E-cadherin and cytokeratin downregulation during EMT