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HMGB2 — TNF
Text-mined interactions from Literome
Yu et al., Shock 2006
:
Similarly, in primary human macrophages,
HMGB1 induced
TNF release is dose-dependently inhibited by anti-TLR4 antibodies ... In primary macrophages from knockout mice,
HMGB1 activates significantly less
TNF release in cells obtained from MyD88 and TLR4 knockout mice as compared with cells from TLR2 knockout and wild-type controls
Voll et al., Isr Med Assoc J 2008
(Autoimmune Diseases...) :
Upon
stimulation with lipopolysaccharides or
tumor necrosis factor-alpha ,
HMGB1 is secreted from certain cells such as monocytes/macrophages and fosters inflammatory responses
Xu et al., Am J Physiol Heart Circ Physiol 2011
(Heart Injuries...) :
However, inhibition of HMGB1 attenuated myocyte TNF-a production after the A/R was challenged ; surprisingly,
HMGB1 itself did not
induce myocyte
TNF-a production