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IL15 — TNF

Text-mined interactions from Literome

Kasyapa et al., J Immunol 1999 : Pretreatment of T cells with rolipram or cAMP analogues inhibited the IL-15 stimulated increases in proliferation, expression of cell surface molecules CD69, ICAM-1, and LFA-1, and release of TNF-alpha from macrophages
De Caterina et al., Am J Clin Nutr 2000 (Arteriosclerosis) : Consumption of the n-3 fatty acid docosahexaenoic acid ( DHA ; 22 : 6n-3 ) reduced endothelial expression of vascular cell adhesion molecule 1 ( VCAM-1 ), E-selectin, intercellular adhesion molecule 1 ( ICAM-1 ), interleukin 6 (IL-6), and IL-8 in response to IL-1, IL-4, tumor necrosis factor , or bacterial endotoxin, with a half-maximal inhibitory concentration ( IC ( 50 ) ) of 1-25 micromol, ie, in the range of nutritionally achievable plasma concentrations
Liu et al., J Immunol 2000 (Inflammatory Bowel Diseases) : Moreover, lamina propria T cells ( LP-T ) from IBD patients were more responsive to IL-15 as compared with controls, and IL-15 alone without a primary T cell stimulus induced IFN-gamma and TNF production by isolated IBD LP-T cells, especially by LP-T cells from patients with Crohn 's disease
Burger et al., Arthritis Res 2000 (Arthritis, Rheumatoid) : IL-1beta and TNF-alpha also induce IL-15 in fibroblast like synoviocytes, which induces the production of IL-17 which in turn potentiates IL-1beta and TNF-alpha production in monocyte-macrophages
Ghigo et al., Infect Immun 2001 (Endocarditis, Bacterial...) : First, interleukin-10 suppressed C. burnetii stimulated production of TNF
Alvarez et al., Cancer Lett 2002 : Similarly, TNF-alpha also caused a moderate increased expression of different anti-inflammatory cytokines such as IL-9 ( 104 % ), IL-10 ( 24 % ) and IL-15 ( 47 % )
Hoontrakoon et al., Am J Respir Cell Mol Biol 2002 (Asthma) : Here we demonstrate that interleukin (IL)-15 , in the presence or absence of tumor necrosis factor (TNF)-alpha , reduces spontaneous apoptosis in freshly isolated human eosinophils
Sugiura et al., Int Immunol 2002 (Dermatomyositis...) : Myoblasts constitutively produced a low level of IL-15 and the production was augmented by stimulation with IFN-gamma, IL-1alpha, IL-1beta, TNF-alpha or lipopolysaccharide (LPS) in a dose dependent manner
Werth et al., J Invest Dermatol 2003 : Although interleukin-12 is considered to act primarily on lymphocytes, provoking a shift from T helper 2 to T helper 1 cells and an increase in lymphocyte derived tumor necrosis factor alpha, we hypothesized that interleukin-12 might also affect tumor necrosis factor alpha secretion from skin cells ... Remarkably, the exogenous interleukin-12 totally blocked ultraviolet-B induced tumor necrosis factor alpha production ... Thus, interleukin-12 strongly inhibits tumor necrosis factor alpha production by noninflammatory skin cells, mostly or entirely through inhibition of gene transcription via an element within the first 1.2 kb of the tumor necrosis factor alpha promoter
Lin et al., Crit Care Med 2003 (Hyperoxia) : Endogenous nitric oxide may be an important endogenous inhibitor of hyperoxia + tumor necrosis factor-alpha induced leukocyte recruitment and subsequently tumor necrosis factor-alpha, interleukin-1 beta, and GRO/CINC-1 release
Jana et al., J Neurochem 2003 : Induction of tumor necrosis factor-alpha (TNF-alpha) by interleukin-12 p40 monomer and homodimer in microglia and macrophages
Maeda et al., J Invest Dermatol 2003 : Among T helper 1 cytokines, interleukin-4 mediated suppression of tumor necrosis factor-alpha was not affected by terfenadine, which, however, markedly restored mRNA expression of interferon-gamma or interleukin-2
Ilangumaran et al., J Immunol 2003 (Lymphoproliferative Disorders) : IL-15 strongly induces TNF-alpha production in SOCS1-deficient CD8+ T cells, indicating that SOCS1 is also a critical regulator of CD8+ T cell activation by IL-15
Tada et al., Hokkaido Igaku Zasshi 1992 (Brain Neoplasms...) : TNF at a low dose ( 10 U/ml ) stimulated production of prostaglandin E2, Mn-superoxide dismutase, interleukin (IL)-6 and IL-8 by glioblastoma cells
Villadsen et al., J Clin Invest 2003 (Disease Models, Animal...) : This antibody effectively blocked IL-15 induced T cell proliferation and monocyte TNF-alpha release in vitro
Ichiyama et al., Inflamm Res 2004 : Moreover, the inhibitory effects of IVIG on IkappaBalpha degradation, interleukin-6 (IL-6) production, and E-selectin expression induced by TNF-alpha were evaluated by Western blot analysis, ELISA, and flow cytometry, respectively
Ebert et al., Clin Exp Immunol 2004 : Furthermore, IL-12 augmented IL-15 stimulated release of serine esterases as well as expression of perforin and FL by IELs, but not TNF-alpha
Cheon et al., J Rheumatol 2004 (Arthritis, Rheumatoid...) : When RA FLS are stimulated with interleukin 1 or tumor necrosis factor-a , WISP3 mRNA is significantly increased
Ozdemir et al., J Immunother 2005 : IL-15 also increased overall perforin and tumor necrosis factor-alpha expression and more prominently in CTLs
Desmet et al., Biochem Pharmacol 2005 : On the contrary, both RSG and TRO significantly potentiated TNF-alpha induced production of granulocyte/macrophage-colony stimulating factor, interleukin (IL)-6 and/or IL-8 in these cells
Silva et al., Inflamm Bowel Dis 2005 (Crohn Disease...) : IL-15 , in the absence of Io + PMA, did not induce the expression of IFN-gamma, TNF-alpha , or IL-2R alpha
Di Sabatino et al., Gut 2006 (Celiac Disease) : Untreated CD IEL, characterised by higher IL-15Ralpha expression, showed increased proliferation, production of IFN-gamma and TNF-alpha , and perforin/granzyme dependent cytotoxicity, and a decreased propensity to apoptosis in response to IL-15
Baranda et al., Rheumatology (Oxford) 2005 (Lupus Erythematosus, Systemic) : In addition, the expression of IL-15 receptor alpha ( IL-15Ralpha ) and membrane bound IL-15 was assessed and the in vitro effects of IL-15 on CD69 and CD64 expression, interferon-gamma and TNF-alpha synthesis, respiratory burst induction and apoptosis were studied
De Francesco et al., Virus Res 2006 : The results show that p17, while ineffective on resting monocytes, exerts an inflammatory action on IL-4 mediated inhibition of TNF-alpha and IFN-gamma production induced by IL-15 stimulation
Ernestam et al., Arthritis Res Ther 2006 (Arthritis, Rheumatoid) : In this study we investigated the effect of TNF blockade ( infliximab ) on the synovial expression of IL-15 in RA in relation to different cell types and expression of other cytokines, to elucidate whether or not IL-15 is a possible target for therapy, independently of TNF blockade
Van Damme et al., J Invest Dermatol 1990 : This study focuses on interferon-beta (IFN-beta), interleukin-6 (IL-6), and interleukin-8 (IL-8) production by fibroblasts and epithelial cells in response to interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha)
Yang et al., Zhonghua Jie He He Hu Xi Za Zhi 2006 (Tuberculosis, Pulmonary) : To investigate the effect of interleukin-7 and interleukin-15 on the production of Th1 cytokines interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha) and Th2 cytokines interleukin-4 (IL-4), IL-10 by peripheral blood mononuclear cells ( PBMC ) from patients with tuberculosis ... IL-15 increased the production of IFN-gamma and TNF-alpha in the patients [ ( 107 +/- 42 ) ng/L to ( 231 +/- 62 ) ng/L, ( 460 +/- 128 ) ng/L to ( 843 +/- 208 ) ng/L, respectively ], but decreased the production of IL-4 and IL-10 [ ( 58 +/- 15 ) ng/L to ( 37 +/- 9 ) ng/L, ( 153 +/- 40 ) ng/L to ( 116 +/- 41 ) ng/L, respectively ] ; IL-15 also increased the production of IFN-gamma and TNF-alpha in the healthy controls [ ( 211 +/- 57 ) ng/L to ( 343 +/- 108 ) ng/L, ( 1,203 +/- 390 ) ng/L to ( 1,468 +/- 235 ) ng/L, respectively ], and decreased the production of IL-4 and IL-10 [ ( 43 +/- 13 ) ng/L to ( 36 +/- 8 ) ng/L, ( 135 +/- 37 ) ng/L to ( 90 +/- 35 ) ng/L, respectively ]
Ramsborg et al., Exp Hematol 2007 (Inflammation) : Finally, IL-15 induced differential expression of TNF receptor superfamily members ( CD27 and CD30 )
Yonekawa et al., Res Commun Mol Pathol Pharmacol 2004 (Liver Failure, Acute) : Interleukin (IL)-15 , an inhibitor of tumor necrosis factor (TNF)-alpha , causes liver injury in mice
Choi et al., FEMS Immunol Med Microbiol 2007 (Candidiasis) : CpG oligodeoxynucleotides protect mice from lethal challenge with Candida albicans via a pathway involving tumor necrosis factor-alpha dependent interleukin-12 induction
Shembade et al., J Virol 2007 : Mouse fibroblasts lacking Ubc13 exhibit impaired Tax activation of NF-kappaB despite normal tumor necrosis factor- and interleukin-1 mediated NF-kappaB activation
Verri et al., Eur J Immunol 2007 (Arthritis, Rheumatoid) : Consistent with this observation, IL-15 induced IL-18 production, and IL-15 or IL-18 injection induced the production of MIP-2, MIP-1alpha, TNF-alpha and LTB4
Tavian et al., Cytokine 2008 (Paracoccidioidomycosis) : In contrast, IL-8 and TNF-alpha levels were not affected by IL-15 suggesting that its effects were not mediated by these cytokines
Zhang et al., Scand J Immunol 2008 : Although its signal transduction pathways in keratinocytes ( KC ) have been partially elucidated, the effects of IL-15 on expression of IL-15, IL-6 and TNF-alpha in KC are unknown ... In contrast, IL-15 increased TNF-alpha transcription in these cells
Inagaki et al., J Biol Chem 2008 : Tumor necrosis factor- and interleukin-1 induced activation of TAK1 was entirely normal in Tab1-deficient MEFs and could activate both mitogen activated protein kinases and NF-kappaB
González-Alvaro et al., Ann Rheum Dis 2009 : Treatment of PBL with leflunomide, cyclosporin A and FK-506 inhibited the IL-15 induced expression of both CD54 and CD69 by PBL, as well as TNF production in co-cultures of activated PBL and THP-1 cells
Lee et al., Biochem Biophys Res Commun 2009 : TNF-alpha augmented the IL-15 induced expression of NK1.1 and CD122 in mature NK cells, and TNF-alpha alone also induced NK cell maturation as well as IL-15 ... TNF-alpha also increased IFN-gamma production in NK cells in the presence of IL-15
Liu et al., J Huazhong Univ Sci Technolog Med Sci 2009 : The aim of this study is to examine the ability of interferon-gamma (IFN-gamma), and tumor necrosis factor-alpha (TNF-alpha) to induce the production of human interleukin-15 ( hIL-15 ) and IL-15 receptor ( IL-15Ralpha ) by human umbilical vein endothelial cells ( HUVECs )
Ichikawa et al., Rheumatol Int 2010 (Arthritis, Rheumatoid) : TNF-alpha induced production of IP-10, but not IL-15 in cultured synovial cells from RA patients
Tyagi et al., Mol Cell Endocrinol 2010 : In addition, like 17beta-estradiol, presence of medicarpin inhibited TNFalpha induced upregulation of interleukin-1 , and -6 mRNA levels in osteoblasts
Gutteberg et al., APMIS 1991 (Sepsis) : Using a whole blood in vitro model, we have investigated the effect of Escherichia coli ( E. coli ), Streptococcus agalactiae ( group B streptococci, GBS ) and tumor necrosis factor alpha (TNF) on the generation of lactoferrin (LF), interleukin-1 beta (IL-1) and tissue thromboplastin (TPL) in healthy newborns at term and their mothers
Elias et al., Chest 1990 (Pneumonia...) : To understand the processes regulating inflammation and fibrosis in the human lung, we characterized the effects of recombinant interleukin-1, tumor necrosis factor , and gamma interferon on fibroblast proliferation, collagen production, interleukin-1-alpha production, interleukin-1-beta production, and interleukin-6 production
Chan et al., Int J Oncol 1997 : Involvement of interleukin-1 in the differentiation inducing activity of tumor necrosis factor-alpha on a murine myeloid leukemia ( WEHI-3B JCS )
González-Álvaro et al., Reumatol Clin 2009 : To analyze the effect of the TNF blocking agents ( aTNF ) on the serum levels of interleukin 15 (IL-15) ... Our data seem to support previous in vitro findings suggesting that TNF is involved in the regulation of IL-15 expression
Carlo et al., J Pediatr 2011 (Cerebral Palsy...) : The analyses were focused on 5 cytokines ( interleukin [ IL] 1ß ; IL-8 ; tumor necrosis factor-a ; regulated upon activation, normal T-cell expressed, and secreted ( RANTES ) ; and IL-2 ) reported to be most predictive of CP in term and late preterm infants
Stone et al., Cell Physiol Biochem 2011 : Interleukin (IL)-15 and its receptors are induced by tumor necrosis factor a (TNF) in the cerebral endothelial cells composing the blood-brain barrier, but it is not yet clear how IL-15 modulates endothelial function
Takeda et al., Int Immunopharmacol 2011 (Orthomyxoviridae Infections) : On day 2, tumor necrosis factor (TNF)-a production in BALF was also reduced significantly, but interferon-a, interleukin-12 , and interferon-? productions were augmented and natural killer ( NK ) cell activity was significantly elevated
Ma et al., J Pharmacol Sci 2012 : We also demonstrated that pretreatment of cells with this compound prevented TNF-a induced expression of NF-?B target genes, such as interleukin 6, interleukin 8, monocyte chemotactic protein 1, cyclooxygenase-2 and inducible nitric oxide
Villacres et al., J Infect Dis 2012 (HIV Infections...) : Peripheral blood mononuclear cells ( PBMCs ) obtained at baseline were used to measure interleukin 1ß (IL-1ß), interleukin 6 (IL-6), interleukin 10 (IL-10), interleukin 12 (IL-12), and tumor necrosis factor a (TNF-a) responses to Toll-like receptor (TLR) 3 and TLR4 stimulation
Gunaydın et al., J Pediatr Surg 2012 (Acute Lung Injury...) : Aspiration of gastrointestinal decontamination agents produced histopathologic changes, elevated levels of malondialdehyde and surfactant protein D, reduced levels of antioxidant enzymes, and increased expression of inflammatory cytokines interleukin-1ß and tumor necrosis factor a. Curcumin treatments effectively attenuated the rats ' pulmonary inflammation responses ( as shown by reduced alveolar damage ), decreased serum malondialdehyde and surfactant protein D levels, and inhibited the expressions of tumor necrosis factor a and interleukin-1ß
Elias et al., Am J Respir Cell Mol Biol 1990 : We determined whether normal human lung fibroblasts expressed cell associated thymocyte stimulating activity in response to recombinant interleukin-1 ( rIL-1 ) ( alpha and beta ) and recombinant tumor necrosis factor ( rTNF )
Tsukamoto et al., Inflamm Bowel Dis 2013 : : Enzyme linked immunosorbent assay and AP assay showed interleukin-1ß induced TNF-a shedding in HCT116 and HT29 cells and TPA induced TNF-a release in U937 cells
Ouyang et al., PloS one 2013 : In the presence of TNF , LMB co-treatment led to accumulation of both IL-15Ra and IL-15 in the nucleus of HeLa cells, suggesting that CRM1 facilitates nuclear export and that TNF enhances CRM1 activity ... The TNF induced secretion of IL-15 was attenuated by pretreatment of cells by brefeldin A that inhibits ER-to-Golgi transport, or by use of domain negative ADP-ribosylation factor 6 (ARF6) that interferes with exocytotic sorting
Gowen et al., Endocrinology 1990 : Human osteoblast cultures derived as out-growths from trabecular bone released tumor necrosis factor ( TNF alpha ) upon stimulation of the cells with human recombinant interleukin 1 ( IL1 ; 10 ( -13 ) -10 ( -11 ) M ), human recombinant granulocyte-macrophage colony stimulating factor ( 100-1000 U/ml ), and bacterial lipopolysaccharide ( 5-500 ng/ml )
Palladino et al., Ciba Found Symp 1987 (Neoplasms, Experimental) : Apart from their direct cytotoxic/cytostatic activities against tumours in vitro and in vivo, the in vivo antitumour activities of TNF-alpha or TNF-beta may involve the following biological activities : the induction of interleukin 1 production ; activation of polymorphonuclear neutrophil functions ; modulation of endothelial cell functions ; and augmentation of specific immune functions
Bachwich et al., Biochem Biophys Res Commun 1986 : Tumor necrosis factor stimulates interleukin-1 and prostaglandin E2 production in resting macrophages ... We have investigated the effect of tumor necrosis factor on the release of interleukin-1 and PGE2 from murine resident peritoneal macrophages ... Tumor necrosis factor causes an increase in the production of interleukin-1 and PGE2 with a maximum induction for both noted at 5.9 X 10 ( -8 ) M
Hoffman et al., Lymphokine Res 1986 : The effects of tumor necrosis factor on the production of interleukin-1 by macrophages
Le et al., J Immunol 1987 : Induction of membrane associated interleukin 1 by tumor necrosis factor in human fibroblasts
Männel et al., Rev Infect Dis 1987 : No TNF induced production of interleukin 1 ( which can induce similar effects ) was detected in macrophage/monocyte cultures
Libby et al., Am J Pathol 1986 : Endotoxin and tumor necrosis factor induce interleukin-1 gene expression in adult human vascular endothelial cells
Ferreira et al., Drugs 1993 (Hyperalgesia...) : The release of tumour necrosis factor-alpha (TNF-alpha) initiates the release of interleukin-1 and interleukin-8, which in turn liberate cyclo-oxygenase metabolites and sympathomimetic amines, respectively
Benveniste et al., Int J Dev Neurosci 1995 : In this study, we demonstrate that transforming growth factor-beta ( TGF-beta ), interleukin-10 (IL-10) and interleukin-6 (IL-6) inhibit tumor necrosis factor-alpha expression by primary rat astrocytes
Tsuji et al., Am J Pathol 1995 (Granuloma...) : Thus, interleukin-1 alpha and inducible nitric oxide synthase were induced mostly in the cells accumulated around the beads and also in some bronchiolar epithelial cells during the early phase ( 1 to 3 days ), whereas tumor necrosis factor-alpha was induced in the cells around the beads at the later resolution phase ( 3 to 7 days )
Aggarwal et al., Exp Cell Res 1995 : Diminished responsiveness of senescent normal human fibroblasts to TNF dependent proliferation and interleukin production is not due to its effect on the receptors or on the activation of a nuclear factor NF-kappa B
Judd et al., Am J Physiol 1995 : ZG cells released IL-6 and TNF , and this release was stimulated by lipopolysaccharide, interleukin-1 alpha, interleukin-1 beta, a protein kinase C activator, and a calcium ionophore without affecting intracellular adenosine 3 ', 5'-cyclic monophosphate ( cAMP ) content
Seatter et al., Arch Surg 1994 (Disease Models, Animal) : Tumor necrosis factor and interleukin-1 regulation by lipopolysaccharide pretreatment
Blasi et al., Infect Immun 1994 : Moreover, pretreatment of macrophages with recombinant TNF for 3 h enhances TNF and induces interleukin-1 production in response to both forms of Candida, while pretreatment for 18 h renders macrophages refractory to any stimuli
Becher et al., J Clin Invest 1996 : Soluble tumor necrosis factor receptor inhibits interleukin 12 production by stimulated human adult microglial cells in vitro
Kumaki et al., Curr Eye Res 1996 : Both non transformed and SV-40 transformed human fetal RPE cells express IL-15 , a T cell growth factor which has similar biological activities to IL-2, and the expression of IL-15 is enhanced by interferon-gamma (IFN-gamma) or tumor necrosis factor-alpha (TNF-alpha) stimulation
Yamamoto et al., Eur J Pharmacol 1996 (Disseminated Intravascular Coagulation) : Plasma interleukin-1 and TNF-alpha levels were elevated by lipopolysaccharide administration and the treatment with FR167653 ( 0.31 mg/kg/h for 4 h ) inhibited the increased plasma interleukin-1 ( 100.0 % ) and plasma TNF-alpha ( 89.2 % ) levels
Ortiz-Arduan et al., Am J Physiol 1996 (Endotoxemia) : Lipopolysaccharides (LPS), interleukin-1 beta, interferon-gamma (IFN-gamma), and TNF-alpha increase the levels of Fas mRNA in cultured mesangial and tubular cells
McInnes et al., Nat Med 1997 (Arthritis, Rheumatoid) : Interleukin-15 mediates T cell dependent regulation of tumor necrosis factor-alpha production in rheumatoid arthritis ... We now report that interleukin-15 (IL-15) can induce TNF-alpha production in RA through activation of synovial T cells ... IL-15 also induced direct TNF-alpha production by synovial T cells
Klegeris et al., Brain Res 1997 (Alzheimer Disease) : First, it was shown that THP-1 cells could be induced to secrete significant amounts of TNF-alpha by interleukin-1 , lipopolysaccharide, interferon-gamma (IFN-gamma) and PMA alone or in combination with each other
Alleva et al., J Immunol 1997 (Inflammation) : The stimulation ( but not the suppression ) of TNF-alpha production by IL-15 required the ( IL-2/IL-15 ) receptor beta chain, as demonstrated by receptor subunit blocking studies and lack of stimulation of Mphi from IL-2Rbeta-deficient mice
Körholz et al., Blood 1997 : IL-15 significantly enhanced T-cell production of interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha) , and IL-10
Qian et al., Blood 1997 : IL-15 also significantly induced interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha) protein production ( days 1, 3, and 6, P < .05, n = 3 ) in CB MNCs. IL-15 stimulated LAK cells induced a significant lytic response against two acute lymphoblastic cell lines and two pediatric neuroblastoma cell lines ... The reduced production of IL-15 from CB MNCs in response to stimulation may contribute to the decrease in IFN-gamma and TNF-alpha production and CB cellular immunity ... However, exogenous IL-15 enhanced IFN-gamma and TNF-alpha production and NK and LAK cytotoxicities in CB MNCs
Li et al., Eur J Pharmacol 1998 (Multiple Sclerosis) : Production of tumor necrosis factor-alpha and the lysosomal cysteine proteinase cathepsin B were markedly inhibited, but production of interleukin-1 increased
Bryson et al., Arch Biochem Biophys 1998 : It potently inhibited interleukin 1- and tumor necrosis factor stimulated proteoglycan release from both nasal and articular cartilage
Fiedler et al., Am J Respir Cell Mol Biol 1998 : The working hypothesis of the studies described herein was that inhibition of proteasome mediated IkappaB degradation would inhibit TNF-alpha induced nuclear factor-kappaB (NF-kappaB) activation, interleukin-8 (IL-8) gene transcription, and IL-8 protein release in A549 cells
Suen et al., Vaccine 1998 : Furthermore, we have studied the effects of IL-12 and IL-15 on induction of IFN-gamma and TNF-alpha production, NK, and LAK activities in CB and APB ... The impaired ability of CB to produce IL-12 and IL-15 in response to stimulation may contribute to the decrease in IFN-gamma, TNF-alpha production, NK and LAK activities
Fulton et al., J Infect Dis 1998 : Regulation of interleukin-12 by interleukin-10, transforming growth factor-beta, tumor necrosis factor-alpha , and interferon-gamma in human monocytes infected with Mycobacterium tuberculosis H37Ra
Neurath et al., Clin Exp Immunol 1999 (Arthritis, Experimental) : MTX reduced spontaneous and IL-15 induced tumour necrosis factor (TNF) production by splenic T cells but not by macrophages from healthy mice in vitro in a dose dependent manner ... Thus, MTX specifically modulates spontaneous and IL-15 induced TNF-alpha production in mice and prevents experimental murine CIA