Gene interactions and pathways from curated databases and text-mining

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EIF4E — IRF6

Text-mined interactions from Literome

Cherla et al., J Leukoc Biol 2006 (MAP Kinase Signaling System) : Stx1 increased eukaryotic translation initiation factor 4E ( eIF4E ) activation by 4.3-fold within 4-6 h, and LPS or Stx1 + LPS treatment increased eIF4E activation by 7.8- and 11-fold, respectively, within 1 h. eIF4E activation required Stx1 enzymatic activity and was mediated by anisomycin, another ribotoxic stress inducer
Wan et al., J Biol Chem 2009 (MAP Kinase Signaling System) : Importantly, LPS induced phosphorylation of MKK3/6, MNK1, and eIF4E was significantly reduced in IRAK2-deficient macrophages compared with wild type macrophages