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MAP3K7 — SMAD6
Pathways - manually collected, often from reviews:
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/BMPR2/BMPR1A-1B/RGM/XIAP complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-XIAP)
→
TAK1/SMAD6 complex (MAP3K7-SMAD6)
(modification, activates)
Kimura et al., J Biol Chem 2000, Yamaguchi et al., EMBO J 1999
Evidence: mutant phenotype, physical interaction
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NCI Pathway Database BMP receptor signaling:
TAK1/SMAD6 complex (MAP3K7-SMAD6)
→
TAK1/TAB family complex (MAP3K7-TAB2_TAB1)
(modification, inhibits)
Kimura et al., J Biol Chem 2000, Yamaguchi et al., EMBO J 1999
Evidence: mutant phenotype, physical interaction
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Kimura et al., J Biol Chem 2000
:
Interestingly, this ectopic expression of
Smad6 blocks BMP2 induced
TAK1 activation and p38 phosphorylation
Gingery et al., Exp Cell Res 2008
:
TAK1/MEK activation induces pro-survival BclX ( L ) expression and TAK1/MEK and
SMAD pathway activation
induces pro-survival Mcl-1 expression
Yumoto et al., J Biol Chem 2013
(Cleft Palate) :
TGF-ß activated Kinase 1 (Tak1) Mediates Agonist induced
Smad Activation and Linker Region Phosphorylation in Embryonic Craniofacial Neural Crest derived Cells