Zhang et al., Lab Invest 2002
(Breast Neoplasms) :
EGFR and ErbB2 differentially regulate Raf-1 translocation and activation ... The role of ErbB2 in the retention of Raf-1 at the plasma membrane was confirmed in BT-20 cells transfected with ErbB2 ... These results suggest that expression of ErbB2 promoted retention of Raf-1 in the plasma membrane, resulting in prolonged activation of the MAP kinase cascade, which may contribute to enhanced malignancy in ErbB2 expressing cancers
Monden et al., Oncol Rep 1996
:
However, azatyrosine inhibited increases in phosphorylation of c-Raf-1 and c-Jun induced by oncogenic c-ErbB-2 Monden et al., Gan To Kagaku Ryoho 1997
:
However, it inhibited increases in phosphorylation of c-Raf-1 induced by oncogenic c-ErbB-2