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MMP16 — OSM
Text-mined interactions from Literome
Li et al., J Immunol 2001
:
We have previously shown that
OSM induces
MMP and tissue inhibitor of metalloproteinase-3 ( TIMP-3 ) gene expression in chondrocytes by protein tyrosine kinase dependent mechanisms ... In the present study, we investigated signaling pathways regulating the
induction of
MMP and TIMP-3 genes by
OSM ... Curcumin also inhibited
OSM induced MMP-1,
MMP-3 , MMP-13, and TIMP-3 gene expression ... Thus,
OSM induces
MMP and TIMP-3 genes in chondrocytes by activating JAK/STAT and mitogen activated protein kinase signaling cascades, and interference with these pathways may be a useful approach to block the catabolic actions of OSM
Hui et al., Arthritis Rheum 2003
(Osteoarthritis, Knee) :
The in vivo data clearly indicated that
OSM + TNFalpha overexpression
increased MMP levels and decreased levels of tissue inhibitor of metalloproteinases 1 ( TIMP-1 ) ... Specifically,
OSM + TNFalpha
induced marked synovial hyperplasia, inflammation, and cartilage and bone destruction with a concomitant increase in
MMP expression in both cartilage and synovium and decreased TIMP-1 expression in the articular cartilage
Sondergaard et al., Osteoarthritis Cartilage 2006
:
TNF-alpha and
OSM induced a pronounced
increase in
matrix metalloproteinase ( MMP ) activity, which was strongly inhibited by calcitonin
Tiffen et al., Mol Endocrinol 2008
:
OSM also
promoted the expression of metalloproteinases MMP3,
MMP12 , and MMP14, which, in vitro, were responsible for OSM-specific apoptosis
Litherland et al., J Biol Chem 2010
:
However,
MMP1 and MMP13
induction by IL-1 +
OSM was inhibited only by aPKC silencing, suggesting that only atypical isoforms play a significant role in complex inflammatory milieus