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DISP1 — SHH

Text-mined interactions from Literome

Tian et al., Development 2005 : Thus, Disp1 activity is only required for paracrine hedgehog protein signaling by the cholesterol modified form of Shh ( N-Shhp ), the normal product generated by auto processing of a Shh precursor protein
Etheridge et al., Development 2010 : Evidence for a role of vertebrate Disp1 in long-range Shh signaling ... Inhibition of Disp1 function, both by RNAi or dominant negative constructs, prevents secretion and results in the accumulation of Shh in source cells ... These observations support a dual role for Disp1 , not only in the secretion of Shh from the source cells, but also in the subsequent transport of Shh through tissue