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HSD11B2 — PTGS2

Text-mined interactions from Literome

Yao et al., Am J Physiol Regul Integr Comp Physiol 2005 (Hypertension) : We investigated whether medullary COX-2 also increases in rats with 11betaHSD2 inhibition and examined its possible role in the development of hypertension ... 11betaHSD2 inhibition also led to medullary COX-2 increase and cortical COX-2 decrease in weaning rats, primarily through activation of MRs ... These data indicate that COX-2 plays a modulating role in the development of hypertension due to 11betaHSD2 deficiency and that 11betaHSD2 regulates renal COX-2 expression by preventing glucocorticoid access to MRs during postnatal development
Zhang et al., J Clin Invest 2009 (Adenocarcinoma...) : Furthermore, pharmacologic inhibition or gene silencing of 11betaHSD2 inhibited COX-2 mediated PGE2 production in tumors and prevented adenoma formation, tumor growth, and metastasis in mice