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ITGA5 — PTGS2
Text-mined interactions from Literome
Han et al., Int J Cancer 2005
(Carcinoma, Non-Small-Cell Lung...) :
COX-2 inhibitors
suppress integrin alpha5 expression in human lung carcinoma cells through activation of Erk : involvement of Sp1 and AP-1 sites ... The
COX-2 inhibitors triggered the phosphorylation of extracellular signal regulated kinase ( Erk ) in a time dependent manner, and the inhibitor of Mek-1/Erk PD98095
prevented their inhibitory effects on
integrin alpha5 expression ... Transient transfection assays showed that the
COX-2 inhibitors
affected integrin alpha5 gene transcription by acting between -92 to -41 bp of the human integrin alpha5 gene promoter ... Overall, these findings suggest that
COX-2 inhibitors
suppress alpha5beta1 integrin expression in NSCLC through effects on integrin alpha5 gene transcription mediated by Erk activation, increased Sp1, decreased AP-1 DNA binding and inactivation of SAPK/JNK signals
Tang et al., Mol Pharmacol 2006
:
At the mechanistic level,
anti-integrin alpha5beta1 and alphavbeta3 antibodies or rhodostomin, a snake venom disintegrin,
attenuated the US-induced
COX-2 expression