Chen et al., J Neurochem 2012
(Alzheimer Disease) :
While Ngb activates Akt and thus inhibits GSK-3ß, simultaneously inhibition of Akt abolishes the effects of Ngb on GSK-3ß inhibition and tau hyperphosphorylation
Zara et al., Gerontology 2013
:
Ngb , promoting Akt phosphorylation, activates cell survival involving cyclic-nucleotide response element binding protein ( CREB )