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SOCS2 — SOCS3

Pathways - manually collected, often from reviews:

• NCI Pathway Database IL2-mediated signaling events: SOCS2 (SOCS2) → IL2R beta/JAK1/LCK/SOCS3/SOCS2 complex (IL2RB-JAK1-LCK-SOCS3-SOCS2) (modification, collaborate)
  Tannahill et al., Mol Cell Biol 2005
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL2-mediated signaling events: SOCS2 (SOCS2) → IL2R beta/JAK1/LCK/SOCS3 complex (IL2RB-JAK1-LCK-SOCS3) (modification, collaborate)
  Tannahill et al., Mol Cell Biol 2005
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL2-mediated signaling events: IL2R beta/JAK1/LCK/SOCS3/SOCS2 complex (IL2RB-JAK1-LCK-SOCS3-SOCS2) → IL2R beta/JAK1/LCK/SOCS3 complex (IL2RB-JAK1-LCK-SOCS3) (modification, collaborate)
  Tannahill et al., Mol Cell Biol 2005
  Evidence: mutant phenotype, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: SOCS3 — SOCS2 (physical association, affinity chromatography technology) Tannahill et al., Mol Cell Biol 2005
• IRef Hprd Interaction: SOCS3 — SOCS2 (in vitro) Tannahill et al., Mol Cell Biol 2005

Text-mined interactions from Literome

Tollet-Egnell et al., Endocrinology 1999 : SOCS-3 was rapidly and transiently induced , whereas SOCS-2 and CIS were increased in a slower fashion
Kiu et al., Growth Factors 2009 : Data from overexpression studies in cell lines suggest that SOCS2 regulates SOCS3 protein degradation, by forming a molecular bridge to an E3 ubiquitin-ligase complex ... In this study, we utilized Socs2 ( - / - ) mice to examine the role of SOCS2 in modulating SOCS3 expression and degradation, and its impact on interleukin-2 (IL-2) and IL-6 signalling in primary haemopoietic cells