Walsh et al., Redox Rep 2009
(Liver Neoplasms) :
Treatment with mithramycin A resulted in a nearly 20 % reduction in Prdx6 mRNA in Hepa1-6 cells, suggesting a possible role for Sp1 in Prdx6 up-regulation
Chhunchha et al., Cell death & disease 2011
:
Also, curcumin failed to activate Prdx6 expression in the presence of Sp1 inhibitors, demonstrating that curcumin mediated increased expression of Prdx6 was dependent on Sp1 activity