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GRK4 — SLC2A4
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Usui et al., EMBO J 2004
:
In this study, we demonstrate that microinjection of anti-GRK2 antibody or siRNA against GRK2 increased insulin stimulated insulin-responsive glucose transporter 4 (GLUT4) translocation, while adenovirus mediated overexpression of wild-type or kinase-deficient
GRK2 inhibited insulin stimulated
GLUT4 translocation as well as 2-deoxyglucose uptake
Dehvari et al., Br J Pharmacol 2012
:
Furthermore, inhibition of
GRK by transfection of the ßARKct construct
inhibited ß ( 2 ) -adrenoceptor mediated glucose uptake and
GLUT4 translocation, and overexpression of a kinase-dead GRK2 mutant ( GRK2 K220R ) also inhibited GLUT4 translocation