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HBD — IL17A

Text-mined interactions from Literome

Wiehler et al., Am J Physiol Lung Cell Mol Physiol 2007 (MAP Kinase Signaling System...) : IL-17A synergistically enhanced HRV-16 induced epithelial production of the neutrophil chemoattractant, IL-8, as well as human beta-defensin-2 (HBD-2) , a chemoattractant for immature dendritic cells and memory T cells, but suppressed viral production of the eosinophil chemoattractant, RANTES
Eyerich et al., J Allergy Clin Immunol 2009 (Dermatitis, Atopic...) : IL-17 dependent induction of the antimicrobial peptide human beta-defensin 2 (HBD-2) in keratinocytes was investigated ... Both healthy and AE keratinocytes upregulated HBD-2 in response to IL-17 , but coexpressed IL-4/IL-13 partially inhibited this effect ... The ineffective IL-17 dependent upregulation of HBD-2 in patients with AE is due to a partial inhibition by the type 2 microenvironment, which could partially explain why patients with AE do not clear S aureus