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IL6 — PAF1
Text-mined interactions from Literome
Nasu et al., Mol Hum Reprod 1999
(Endometrial Neoplasms...) :
C-PAF stimulated
IL-6 and IL-8 transcription in ESC
Wu et al., FASEB J 2003
(Reperfusion Injury) :
The activated
PAF increased the mucosal
IL-6 and PECAM-1, enhanced the expression of FasL but not Fas, and led to the cleavage of Bid and the release of cytochrome c from mitochondria to activate caspase-9
Thivierge et al., J Allergy Clin Immunol 1992
:
Inhibition of 5-lipoxygenase pathway by AA-861 or MK 886 inhibited the
PAF induced augmentation of both
IL-6 and LTB4 production, suggesting an implication of endogenous leukotrienes in this mechanism
Buke et al., Med Princ Pract 2004
(Hepatitis B, Chronic) :
The aim of this study was to determine tumor necrosis factor alpha (TNF-alpha) and
interleukin-6 (IL-6) release in
response to
platelet activating factor (PAF) induction in peripheral blood mononuclear cells ( PBMCs ) from chronic hepatitis B virus ( HBV ) carriers ... Compared with group A, PBMCs from naturally immune subjects and chronic HBV carriers produced significantly higher amounts of TNF-alpha and
IL-6 in
response to
PAF
Szappanos et al., Naunyn Schmiedebergs Arch Pharmacol 2005
:
Finally, up to 2 mug/ml,
PAF did not
induce the production of pro-inflammatory cytokines such as
IL-6 , IL-8, and TNF-alpha
Cheng et al., Am J Physiol Gastrointest Liver Physiol 2005
(Esophagitis...) :
IL-6 causes production of H2O2,
PAF , and other unidentified inflammatory mediators
Kushikata et al., Neurosci Lett 2006
(Fever) :
PAF and its receptor are found in brain and PAF affects or is
affected by the production of sleep promoting cytokines such as
interleukin-1
Cheng et al., Am J Physiol Gastrointest Liver Physiol 2006
(Disease Models, Animal...) :
PAF-receptor mRNA levels were not detected by RT-PCR in normal mucosa, but were significantly elevated after exposure to HCl, indicating that HCl causes production of PAF and expression of PAF receptors in esophageal mucosa and that
PAF causes production of
IL-6 ... In the circular muscle,
PAF causes production of additional
IL-6 that activates NADPH oxidase to induce production of H ( 2 ) O ( 2 )
Cheng et al., J Pharmacol Exp Ther 2006
(Esophagitis) :
In circular muscle, exogenous
PAF induced sequential formation of
IL-6 , H ( 2 ) O ( 2 ), IL-1beta, and PAF
Pignol et al., Mediators Inflamm 1994
:
The aim of the present study was to investigate the possible
effect of
platelet activating factor (PAF) , by comparison with interleukin-1beta and polyriboinositic/polyribocytidylic ( poly I-C ) acid, on
IL-6 production by L 929 mouse fibroblasts ...
Lyso-PAF ( 5 muM ) also
increased IL-6 activity from fibroblasts to a similar extent compared with 5 muM PAF ... In addition, the
IL-6 activity
induced by 5 muM
PAF was still observed when the specific PAF antagonist, BN 52021 ( 10 muM ), was added to the incubation medium of L 929 cells ... The in vivo
effect of
PAF on
IL-6 production was also investigated in the rat ... The increase of
IL-6 induced by 3 mug/kg
PAF was not observed when the animals were treated with the PAF antagonist, BN 52021 ( 1 to 60 mg/kg0
Wang et al., Mediators Inflamm 1996
:
Our previous studies have shown that EsA could reduce the release of
platelet activating factor (PAF) from rat macrophages, and
inhibit interleukin-1 and interleukin-6 production from routine macrophages ... Our previous studies have shown that EsA could reduce the release of
platelet activating factor (PAF) from rat macrophages, and
inhibit interleukin-1 and
interleukin-6 production from routine macrophages
Engelberts et al., Lymphokine Cytokine Res 1991
(Disease Models, Animal...) :
Further, the
role of
PAF released in response to a challenge with LPS in the regulation of TNF and
IL-6 production was investigated ... LPS induced
PAF secretion was not
involved in the regulation of
IL-6 secretion
Braquet et al., Int Arch Allergy Appl Immunol 1991
:
We compared the
effects of
platelet activating factor (PAF) , interleukin-1 beta (IL-1 beta) and polyriboinositic-polyribocytidylic acid ( poly-I:C ) on
IL-6 production by confluent L929 mouse fibroblasts ... At concentrations above 1 microM,
PAF dose-dependently
enhanced IL-6 production ; at 5 microM PAF this increase ( 72.7 +/- 19.9 U/ml ) was higher than that evoked by 100 U/ml IL-1 beta ( 5.7 +/- 0.4 U/ml ) or 50 micrograms/ml poly-I:C ( 39.3 +/- 6.7 U/ml ) ... The
IL-6 production
induced by 5 microM
PAF was not inhibited by addition of the specific PAF antagonist BN 52021 ( 10 microM ) to the incubation medium
Sharif et al., Molecular vision 2009
:
PAF induced production of
IL-6 , IL-8, and GM-CSF from HCECs was also blocked by these PAF antagonists ( IC ( 50 ) =4.6- 8.6 microM )
Sharif et al., J Ocul Pharmacol Ther 2010
:
However,
PAF did not
stimulate the generation of
IL-6 , IL-8, TNF-alpha, and MMP-1 to any significant level and in a consistent manner
Harnett et al., Journal of neurogastroenterology and motility 2010
:
In circular muscle,
PAF causes production of
IL-6 , and IL-6 causes production of additional H ( 2 ) O ( 2 ), through activation of reduced nicotinamide adenine dinucleotide phosphate ( NADPH ) oxidases
Verouti et al., Atherosclerosis 2011
:
PAF effects on MCP-1 and
IL-6 secretion in U-937 monocytes in comparison with oxLDL and IL-1ß effects
Pirotzky et al., Clin Immunol Immunopathol 1990
:
In contrast,
PAF ( 0.1 nM-1 microM ) did not
increase IL-6 production from glomeruli or mesangial cells
Bussolino et al., Biochim Biophys Acta 1987
:
These findings indicate that
interleukin 1
induces the
PAF synthesis by a deacylation/reacetylation mechanism into human endothelial cells
Gutierrez et al., Clin Exp Immunol 1995
:
IL-1 beta and
IL-6 stimulate the production of
platelet activating factor (PAF) by cultured rabbit synovial cells
Roth et al., J Exp Med 1996
:
PAF induced transcription of protooncogenes c-fos and c-jun as well as of
interleukin (IL)-6 and IL-8 genes in human fibroblasts ... Using signaling inhibitors, we demonstrate that
PAF induced transcription of the c-fos,
IL-6 , and IL-8 genes, as well as proliferation, require activation of pertussis toxin-sensitive G proteins, tyrosine kinases, and protein kinase C ( PKC )
Denizot et al., Eur Cytokine Netw 1996
:
We have assessed whether
PAF stimulates
IL-6 and TNF-alpha production by human bone marrow stromal cells ( mostly fibroblast-like cells )
Cardile et al., Cytokine 1996
:
The
effect of ether lipid 1-O-Octadecyl-2-O-methoxy-rac-glycero-3-phosphocholine ( ET-18-OCH3 ),
platelet activating factor (PAF) and carbamyl activating factor ( CPAF ) on the release of
IL-6 in human thymic epithelium cultivated in vitro was studied
Dupuis et al., Res Immunol 1997
:
By contrast, M-CSF ( 1000 U/ml ), GM-CSF ( 100 ng/ml ), IL1, IL3,
IL6 and stem cell factor ( 10 ng/ml ) did not
stimulate PAF production
Gaumond et al., J Cardiovasc Pharmacol 1997
(Second Messenger Systems) :
Because PAF can stimulate IL-6 production in monocytes, macrophages, and endothelial cells, our study was undertaken to determine whether
PAF could
induce IL-6 production by SMCs and to define the underlying signaling pathways ...
PAF dependent
IL-6 production was also prevented by inhibition of tyrosine kinases with genistein or erbstatin ... Inhibition of eicosanoid production by blocking either phospholipase A2 or cyclooxygenase also abrogated the
effect of
PAF on
IL-6 production ... Moreover, inhibition of Ca2+-calmodulin activity with W7 or blocking of calcium channels with verapamil or nifedipine prevented
PAF mediated enhancement of
IL-6 production
Johnson et al., J Surg Res 1998
:
To determine if changes in elastase release might be due to
IL-6 induced generation of
PAF , WEB 2347 ( 50 microM ) was preincubated with selected cells for 20 min. Surface expression of beta 2 integrins was measured by flow cytometry after incubating with labeled antibodies to CD11b and CD18
Sharif et al., Invest Ophthalmol Vis Sci 1998
:
Histamine ( 100 microM ) and interleukin-1alpha ( IL-1alpha, 10 ng/ml ) significantly stimulated
IL-6 and granulocyte macrophage colony stimulating factor release, and histamine, BK, and
PAF stimulated the mRNA for MMP-1 in these cells