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PTPN1 — SRC

Pathways - manually collected, often from reviews:

• NCI Pathway Database Signaling events mediated by PTP1B: PTP1B (PTPN1) → Src (SRC) (modification, activates) Bjorge et al., J Biol Chem 2000*, Cheng et al., J Biol Chem 2001*, Liang et al., J Biol Chem 2005*
  Evidence: mutant phenotype, assay, other species
• Reactome Reaction: PTPN1 → SRC (reaction) Shattil et al., Trends Cell Biol 2005, Arias-Salgado et al., J Cell Biol 2005

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: SRC — PTPN1 (direct interaction, enzymatic study) Jung et al., Biochem Biophys Res Commun 1998*
• IRef Hprd Interaction: SRC — PTPN1 (in vitro) Bjorge et al., J Biol Chem 2000*, Yamamoto et al., Mol Hum Reprod 2002*, Stover et al., J Biol Chem 1996, Somani et al., J Biol Chem 1997*
• IRef Hprd Interaction: SRC — PTPN1 (in vivo) Bjorge et al., J Biol Chem 2000*, Yamamoto et al., Mol Hum Reprod 2002*, Stover et al., J Biol Chem 1996, Somani et al., J Biol Chem 1997*
• IRef Intact Interaction: SRC — PTPN1 (phosphorylation reaction, protein kinase assay) Jung et al., Biochem Biophys Res Commun 1998*
• IRef Intact Interaction: SRC — PTPN1 (dephosphorylation reaction, phosphatase assay) Bjorge et al., J Biol Chem 2000*
• IRef Intact Interaction: SRC — PTPN1 (physical association, coimmunoprecipitation) Ragab et al., J Biol Chem 2003*
• IRef Intact Interaction: SRC — PTPN1 (physical association, anti bait coimmunoprecipitation) Arias-Salgado et al., J Cell Biol 2005
• IRef Intact Interaction: SRC — PTPN1 (dephosphorylation reaction, phosphatase assay) Wang et al., Proc Natl Acad Sci U S A 2006*
• IRef Intact Interaction: SRC — PTPN1 (physical association, bimolecular fluorescence complementation) Anderie et al., Cell Signal 2007*
• IRef Intact Interaction: SRC — PTPN1 (dephosphorylation reaction, phosphatase assay) Zhu et al., Cancer Res 2007*
• IRef Intact Interaction: Complex of SRC-ITGB3-PTPN1-SRC-PTPN1-ITGB3 (association, anti tag coimmunoprecipitation) Arias-Salgado et al., J Cell Biol 2005
• IRef Intact Interaction: Complex of SRC-BCAR1-PTPN1 (association, coimmunoprecipitation) Liang et al., J Biol Chem 2005*

Text-mined interactions from Literome

Dadke et al., J Biol Chem 2003 : Here we show that protein-tyrosine phosphatase 1B ( PTPIB ) activates Src , thereby initiating the activation of a Rac dependent pathway leading to cytoskeletal remodeling
Liang et al., J Biol Chem 2005 : We show that down-regulation of PTP1B activity with small molecule inhibitors suppresses cell spreading and migration to fibronectin, increases Tyr ( 527 ) phosphorylation in Src , and decreases phosphorylation of FAK, p130 ( Cas ), and ERK1/2
Bartholomew et al., Exp Cell Res 2005 : We found that neither p130cas nor Src is required for the inhibition of PTP1B activity by adhesion to extracellular matrix proteins
Zhu et al., Cancer Res 2007 (Colonic Neoplasms) : Overexpression of PTP1B increased Src specific activity in colon cancer cells by reducing phosphorylation at Y530 of Src
Fuentes et al., Mol Biol Cell 2009 : Our results highlight the role of microtubules and cell contacts in the positioning of ER-bound PTP1B to the peripheral region of growth cones, which may be required for the positive role of PTP1B in axon elongation, filopodia stabilization, and Src activity
Arias-Romero et al., Cancer Res 2009 (Cell Transformation, Neoplastic) : Activation of Src by protein tyrosine phosphatase 1B Is required for ErbB2 transformation of human breast epithelial cells ... Activation of ErbB2, but not ErbB1, increases PTP1B expression, and increased expression of PTP1B activates Src and induces a Src dependent transformed phenotype
Wang et al., Med Oncol 2012 (Disease Progression...) : Overexpression of PTP1B promoted the proliferation and in vivo tumorigenesis of MKN45 cells and also increased the phosphorylation levels of Akt, Erk1/2, and FAK and the activity of Src
Liu et al., Mol Cell Biol 1998 (Cell Transformation, Neoplastic) : Expression of WT-PTP1B reduces formation of p130Cas-Crk complexes and inhibits mitogen activated protein kinase activation by Src and Crk
Sun et al., Oncogene 1998 : Third, protein tyrosine phosphatase 1B preferentially dephosphorylates the Src autophosphorylation site and allows for Src regulation by Csk