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Hourton et al., Eur J Biochem 2001
(Arteriosclerosis) :
LPS-treatment ( 1 microg.mL(-1) ) of macrophages
increased PAF binding and PAF-R mRNA expression by 56 % ( P < 0.05 ) and twofold ( P < 0.01 ), respectively
Mariano et al., Shock 2003
:
These results indicate an inhibitor effect of NO on the spontaneous and TNF or
LPS induced synthesis of
PAF by human PMN, MO, and EC
Bulger et al., Shock 2003
(Lung Injury...) :
We have previously shown that
PAF-AH significantly
inhibits macrophage activation by
lipopolysaccharide (LPS) in vitro
Tonks et al., J Leukoc Biol 2003
(Respiratory Distress Syndrome, Adult) :
Taken together, these findings indicate that pulmonary surfactant, particularly the DPPC component, can inhibit
LPS stimulated
PAF production via perturbation of the cell membrane, which inhibits the activity of specific membrane associated enzymes involved in PAF biosynthesis
Nakamura et al., FEBS Lett 1992
:
PAF receptor
activation by
LPS may represent a novel important pathway in the pathogenesis of circulatory collapse and systemic thrombosis caused by endotoxin
Jakubowski et al., J Physiol Pharmacol 2004
:
These results indicate that PAF and TXA ( 2 ) but not cysLTs mediate the instant heart response induced by LPS, while
PAF alone
mediates a delayed NOS-2 induction by
LPS
Buduneli et al., J Periodontol 2004
(Alveolar Bone Loss...) :
Doxycycline + alendronate +
LPS group also significantly
reduced LTB4 and
PAF levels, although doxycycline provided the most reduction in the levels of these mediators ( P < 0.05 )
Shindou et al., J Immunol 2005
:
In this study we investigated the priming
effect of
LPS on the acetyltransferase activation by
PAF in TLR4-knockout ( KO ) mice, MyD88-KO mice, and Toll/IL-1R domain containing adaptor inducing IFN-beta ( TRIF ) -KO mice
De Plaen et al., Immunology 2006
:
However, it remains elusive whether enterocytes release CXCL2 in
response to
LPS and TNF via a NF-kappaB dependent pathway and whether this involves the endogenous production of TNF and
PAF
Slomiany et al., J Physiol Pharmacol 2007
:
A potentiation in the countering capacity of leptin on the
LPS induced up-regulation in apoptosis, arachidonic acid release and
PAF generation was attained in the presence of ERK inhibitor, PD98059, while PI3K inhibitor, wortmannin had no effect
Engelberts et al., Lymphokine Cytokine Res 1991
(Disease Models, Animal...) :
LPS induced
PAF secretion was not involved in the regulation of IL-6 secretion
Kunze et al., Prostaglandins Other Lipid Mediat 2010
(Inflammation) :
An immediate low release of PGE ( 2 ) was
induced by PAF, phorbol ester and arachidonic acid but not by IL1beta, TNF-alpha and
LPS whereas a delayed high release of PGE ( 2 ) was induced by the inflammatory agents IL1beta, TNF-alpha and LPS but not by
PAF , phorbol ester and arachidonic acid
Liu et al., Chin Med J (Engl) 2010
(Reperfusion Injury) :
After treatment with 2 L/min of 250 ppm CO i.p., the increase of
PAF , ICAM-1, MDA, MPO, and cell apoptotic rate
induced by
LPS was markedly reduced ( P < 0.05 or 0.01 ), and accompanied by ameliorating intestine injury
Sun et al., J Clin Invest 1988
(Disease Models, Animal...) :
In the present study, we have shown that ( a ) TNF caused PAF production in bowel tissue ; ( b ) the effects of TNF and LPS on PAF production in the intestine are additive ; ( c ) TNF and
LPS are synergistic in inducing bowel necrosis ; and ( d ) TNF induced bowel necrosis is
due to
PAF release and can be prevented by pretreatment with PAF antagonists
Camussi et al., J Immunol 1995
:
The biosynthesis of
platelet activating factor (PAF) during Gram negative
involves the interaction of
LPS with the cells of the host ... The synthesis of
PAF by MO and MC
involves two proteins, plasma
LPS binding protein (LBP) and cell membrane CD14 (mCD14) ... Moreover, LeuM3, 28C5, and 18E12 mAbs that were themselves unable to stimulate the synthesis of PAF blocked
PAF synthesis
initiated by
LBP-LPS complex ... In contrast, sCD14 was shown to be required for
LPS induced synthesis of
PAF by HUVEC, which did not express mCD14
Karasawa et al., J Biochem 1994
(Shock, Septic) :
These results suggest that the acetylhydrolase, which accumulates in the peritoneal cavity, infiltrates from the plasma in
response to
LPS , and then participates in the exclusion of
PAF during endotoxin shock
Tan et al., J Immunol 1996
:
We conclude that : 1 ) both PAF and
LPS induce gene transcription and enzyme activation of PLA2-II in the small intestine ; 2 ) PAF up-regulates PLA2-II via PMN activation ; 3 ) LPS effect is
independent of endogenous
PAF formation ; and 4 ) different pathways exist for PAF and LPS in the regulation of intestinal PLA2-II gene expression in vivo
Komatsu et al., Dig Dis Sci 1996
(Drug-Induced Liver Injury) :
These results suggest that
PAF play an important role in the
GalN-LPS induced hepatic injury and that PAF receptor antagonist reduces the neutrophil adherence to hepatic endothelial cells in the liver
Herbert et al., J Cell Physiol 1996
(Anoxia...) :
The priming
effect of
PAF with regard to
LPS occurred in a time- and dose dependent manner and was inhibited by the PAF receptor antagonist SR 27417
Qu et al., Prostaglandins 1996
:
We found that
LPS ( 2-10 mg/kg, iv, 90 min )
stimulated PAF production in the rat ileum, but not in the jejunum and colon
Balsinde et al., Biochem J 1997
(Leukemia P388) :
PAF also activated phospholipase A2 (PLA2) and enhanced arachidonic acid ( AA ) release in P388D1 macrophages, and bacterial
lipopolysaccharide (LPS) increased the responsiveness of these cells to PAF
Svetlov et al., Biochim Biophys Acta 1997
:
The
LPS induced increase in cellular
PAF levels was rapid, sustained and attained maximal levels within 30 min following LPS stimulation
Lo et al., Arch Surg 1997
:
Furthermore, inhibiting
PAF production with AACOCF3, or manoalide, also
inhibited LPS induced Mphi TNF mRNA expression