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CDK1 — PPP2CA
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Forester et al., Proc Natl Acad Sci U S A 2007
:
Control of mitotic exit by
PP2A regulation of Cdc25C and
Cdk1
Lorca et al., J Cell Sci 2010
:
When
PP2A is prematurely inhibited in the absence of cyclin-B-Cdc2 activation, endogenous
cyclin-A-Cdc2 activity
induces irreversible aberrant mitosis in which there is, first, partial transient phosphorylation of mitotic substrates and, second, subsequent rapid and complete degradation of cyclin A and cyclin B, thus promoting premature and rapid exit from mitosis