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AFP — TP53
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Ogden et al., J Biol Chem 2000
(Carcinoma, Hepatocellular...) :
Hepatitis B viral transactivator HBx alleviates
p53 mediated repression of
alpha-fetoprotein gene expression ... By utilizing in vitro chromatin assembly of DNA templates prior to transcription analysis, we have demonstrated that HBx functionally disrupts
p53 mediated repression of
AFP transcription through protein-protein interaction
Ogden et al., J Biol Chem 2001
:
p53 targets chromatin structure alteration to
repress alpha-fetoprotein gene expression ... We have shown that
p53 represses hepatic-specific
alpha-fetoprotein (AFP) gene expression by direct interaction with a composite HNF-3/p53 DNA binding element
Gong et al., Zhonghua Gan Zang Bing Za Zhi 2005
(Carcinoma, Hepatocellular...) :
[ Molecular mechanism of HCV NS5A on
p53 's
inhibition of
AFP expression in hepatocellular carcinoma cells ]
Cui et al., J Biol Chem 2005
(Carcinoma, Hepatocellular...) :
Transient co-transfection of p53 family members showed that
p53 and transactivating (TA)-p73, but not TA-p63,
repress endogenous
AFP transcription additively or independently
Ryder et al., J Clin Pathol 1996
(Carcinoma, Hepatocellular...) :
The presence of
anti-p53 was
independent of serum
alpha-fetoprotein and was detected in 50 % of small tumours while only 8 % were alpha-fetoprotein positive
Lee et al., Mol Cell Biol 1999
(Carcinoma, Hepatocellular...) :
p53 mediated repression of
alpha-fetoprotein gene expression by specific DNA binding ... This mechanism for
p53 mediated repression of
AFP gene expression may be active during hepatic differentiation and lost in the process of tumorigenesis