Schuler et al., Cell Death Differ 2003
:
Using early-passage embryonic fibroblasts ( MEF ) from wild-type ( wt ), p53 ( -/- ) and bax ( -/- ) mice, we observe a p53 dependent translocation of Bax to the mitochondria and a release of mitochondrial Cytochrome c during stress induced apoptosis ... At a single-cell level, enforced expression of p53 is sufficient to induce Bax translocation and Cytochrome c release
Zhang et al., J Pharmacol Sci 2004
:
Cytochrome c release from oridonin treated apoptotic A375-S2 cells is dependent on p53 and extracellular signal regulated kinase activation