Gene interactions and pathways from curated databases and text-mining

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APOA4 — APOB

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Foth et al., Zentralbl Gynakol 2000 : Apolipoprotein B, cholesterol and LDL-Cholesterol decreased, apolipoprotein A 1 increased
Sun et al., J Biol Chem 2002 (Arteriosclerosis...) : Lipoprotein(a) enhances advanced atherosclerosis and vascular calcification in WHHL transgenic rabbits expressing human apolipoprotein ( a )
Scanu et al., Ann Epidemiol 1992 (Arteriosclerosis...) : The role that lipoprotein ( a ) size and density heterogeneity and apolipoprotein ( a ) polymorphism might play in the intima accumulation of apolipoprotein B is not established
Black et al., Biochem J 1992 : Apo B may be specifically down-regulated by the chylomicron secretory blockade induced by Pluronic L-81
Matthews et al., N Engl J Med 1989 (Coronary Disease) : In menopausal women who received hormone-replacement therapy, HDL and LDL cholesterol levels did not change, but the levels of triglycerides ( +0.42 vs. -0.04 mmol per liter ; P less than 0.001 ), apolipoprotein A-I ( +0.18 vs. +0.03 g per liter ; P less than 0.01 ), and apolipoprotein A-II ( +0.05 vs. -0.03 g per liter ; P less than 0.05 ) increased as compared with premenopausal controls
Rovamo et al., Pediatr Res 1985 (Gastrointestinal Diseases) : Serum apolipoprotein A-I concentrations were unaltered, apolipoprotein A-II underwent a transient increase, and apolipoprotein B increased monotonically during parenteral nutrition
Levy et al., FEBS Lett 1996 : Adding insulin ( 3 mU ) to the serum-free medium of cultured jejunal explants from human fetuses ( 17-20 weeks ) reduced triglyceride and chylomicron production and inhibited apo B-48 and apo B-100 secretion
Taggart et al., Diabet Med 1997 (Diabetes Mellitus, Type 2) : The postprandial chylomicron apolipoprotein B48 response of both diabetic and control subjects to the cholesterol meal was less than to the cholesterol-free meal ( p < 0.001 )