Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Yoon et al., J Biol Chem 2007 (Breast Neoplasms) : In addition, the activation of mTOR by the overexpression of RHEB in MDA-MB-231 cells increased the synthetic rates of both FASN and ACCalpha
Spencer et al., J Virol 2011 : Processing of SREBP-2 was found to be dependent on mTOR activity ; pharmaceutical inhibition of mTOR blocked HCMV induced SREBP-2 processing and prevented the induction of fatty acid biosynthesis and ACC1 expression
Sviripa et al., Bioorg Med Chem Lett 2013 : AMPK also regulates lipid synthesis by inhibiting acetyl-CoA carboxylase (ACC) and regulates mTOR signaling by activating TSC2