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ADM — MAPK4

Text-mined interactions from Literome

Parameswaran et al., Eur J Pharmacol 1999 : SB203580 significantly reversed the effects of adrenomedullin on [ 3H ] thymidine incorporation and cytoplasmic DNA fragmentation, and inhibited only P38 MAPK activity ... Wortmannin also inhibited adrenomedullin stimulated P38 MAPK activity without affecting ERK2 and JNK1 activities ... These results indicate that : ( a ) In rat mesangial cells adrenomedullin mediated inhibition of [ 3H ] thymidine incorporation and stimulation of nucleosome associated cytoplasmic DNA fragmentation are sensitive to SB203580, and ( b ) adrenomedullin activates a P38 MAPK through a wortmannin-sensitive kinase
Parameswaran et al., Eur J Pharmacol 1999 : Associated with the changes in proliferation and apoptosis, adrenomedullin decreased ERK2 activity, and increased JNK1 and P38 MAPK activities ... In addition, only adrenomedullin mediated changes in ERK2 and P38 MAPK activities were inhibited by H89 while, adrenomedullin stimulated JNK1 was not consistently inhibited by the protein kinase-A inhibitor
Andreis et al., Endocrinology 2000 : ADM ( 10 ( -8 ) M ) stimulated TK and p42/p44 MAPK activity in dispersed ZG, but not ZF, cells, and the effect was reversed by either 10 ( -6 ) M CGRP- ( 8-37 ) and ADM- ( 22-52 ) or preincubation with 10 ( -5 ) M tyrphostin-23
Liu et al., Chin Med Sci J 2003 (Coronary Restenosis) : In addition, ET and AII attenuated the expression of HRG-1 in aorta and stimulated mitogen activated protein kinase ( MAPK ) activity, while CGRP and Adm potentiated the expression of HRG-1 and inhibited MAPK
Yang et al., Regul Pept 2004 : ADM inhibited LPA induced proliferation in adventitial cells and attenuated the activity of mitogen activated protein kinase ( MAPK ) stimulated by LPA
Shi et al., Di Yi Jun Yi Da Xue Xue Bao 2005 : Ca ( 2+ ), MAPK , CaM-PK and p38 signal transduction pathways may play major roles in U II-stimulated secretion of Adm in HVECs
Liu et al., Chin Med J (Engl) 2005 : Western blot analysis showed that ADM did not change the expression of t-MAPKs but increased p-SAPK/JNK and p-P38MAPK levels and decreased p-ERK level
Chini et al., Biochem Biophys Res Commun 1995 : In the present study we explored whether ADM stimulates cAMP system in glomerular mesangial cells ( MC ) and whether it can via `` negative-crosstalk '' inhibit the mitogen activated protein kinase ( MAPK ) and thus suppress proliferation of MC
Haneda et al., Kidney Int 1996 : Beraprost sodium, an analogue of PGI2, and adrenomedullin , a cAMP raising agent, inhibited ET-1 induced activation of MAPK
Chini et al., Kidney Int 1997 : Further, ADM inhibited PDF stimulated mitogenesis and activation of MAPK in cultured vascular smooth muscle cells ( VSMC )
Coppock et al., Biochem J 1999 : Using kinase-substrate assays, Mono Q FPLC and ` phospho-specific ' Western blotting, we found that adrenomedullin alone abolished basal mitogen activated protein kinase ( MAPK ) activity and dose-dependently inhibited platelet-derived-growth-factor stimulated MAPK activity