Vu et al., Biochem Biophys Res Commun 2009
:
The wild-type ETV6/FLT3 fusion protein in transfected cells was a constitutively activated tyrosine kinase that led to up-regulation of PIM-1 and activations of STAT5, AKT , and MAPK
Guo et al., Oncogene 2010
(Cell Transformation, Neoplastic) :
In addition, AKT1 ( E17K ) delays loss of Pim-1 and Pim-2 protein levels on v-Abl inactivation, which suggests that there exists reciprocal signaling between AKT and Pim in v-Abl transformants
Walpen et al., Biochem Biophys Res Commun 2012
:
Inhibition of mTOR and AKT in normal MAEC resulted in significantly elevated PIM1 protein levels in the cytosol and in the nucleus