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From these results, we conclude that activation of mTOR/p70S6K by ANG II in vascular endothelium may contribute to impairment of insulin stimulated vasodilation through phosphorylation of IRS-1 at Ser ( 636/639 )
Wen et al., Placenta 2005 :
Ang-2 activated mTOR via PI-3 kinase dependent signaling ; whereas glucose mediated mTOR activation was PI-3 kinase independent and involved a novel nutrient sensor, glutamine fructose-6-phosphate amidotransferase ( GFAT )
Shiojima et al., J Clin Invest 2005 (Cardiomyopathy, Dilated...) :
Enhanced angiogenesis in the acute phase was associated with mammalian target of rapamycin dependent induction of myocardial VEGF and angiopoietin-2 expression