UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

NCI Pathway Database DNA-PK pathway in nonhomologous end joining: Aprataxin (APTX) → Ku/Artemis/DNA-PKcs (dimer)/Pol Mu/XRCC4 (dimer)/Ligase IV/Aprataxin complex (XRCC6-XRCC5-DCLRE1C-PRKDC-POLM-XRCC4-LIG4-APTX) (modification, collaborate)
Clements et al., DNA repair 2004, Ahel et al., Nature 2006
Evidence: mutant phenotype, physical interaction
NCI Pathway Database DNA-PK pathway in nonhomologous end joining: Aprataxin (APTX) → Ku/Artemis/DNA-PKcs (dimer)/Pol Mu/XRCC4 (dimer)/Ligase IV complex (XRCC6-XRCC5-DCLRE1C-PRKDC-POLM-XRCC4-LIG4) (modification, collaborate)
Clements et al., DNA repair 2004, Ahel et al., Nature 2006
Evidence: mutant phenotype, physical interaction
NCI Pathway Database DNA-PK pathway in nonhomologous end joining: Ku/Artemis/DNA-PKcs (dimer)/Pol Mu/XRCC4 (dimer)/Ligase IV/Aprataxin complex (XRCC6-XRCC5-DCLRE1C-PRKDC-POLM-XRCC4-LIG4-APTX) → Ku/Artemis/DNA-PKcs (dimer)/Pol Mu/XRCC4 (dimer)/Ligase IV complex (XRCC6-XRCC5-DCLRE1C-PRKDC-POLM-XRCC4-LIG4) (modification, collaborate)
Clements et al., DNA repair 2004, Ahel et al., Nature 2006
Evidence: mutant phenotype, physical interaction