Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Takei et al., J Neurosci 2004 : Brain derived neurotrophic factor induces mammalian target of rapamycin dependent local activation of translation machinery and protein synthesis in neuronal dendrites ... In parallel, BDNF induced the phosphorylation of tuberin and the activation of mTOR in dendrites and the synaptoneurosome fraction
Slipczuk et al., PloS one 2009 : BDNF activates mTOR to regulate GluR1 expression required for memory formation
Fortin et al., J Neurosci 2012 : Activation of CaMKK by BDNF requires transient receptor potential canonical ( TRPC ) channels as SKF-96365, but not the NMDA receptor antagonist d-APV, prevented BDNF induced GluA1 surface expression as well as phosphorylation of CaMKI, AKT ( T308 ), and mTOR
Wuchter et al., J Neurosci 2012 : Gephyrin is associated with inactive mTOR and becomes released upon BDNF dependent mTOR activation
Briz et al., J Neurosci 2013 : In rat hippocampal slices, cortical synaptoneurosomes, and cultured neurons, BDNF induced mTOR pathway activation and protein translation were blocked by calpain inhibition ... In cultured cortical neurons, knockdown of calpain-2, but not calpain-1, by small interfering RNA completely suppressed the effect of BDNF on mTOR activation ... Our results reveal a critical role for calpain-2 in BDNF induced mTOR signaling and dendritic protein synthesis via PTEN, hamartin, and tuberin degradation