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BRAF — KRAS

Pathways - manually collected, often from reviews:

• KEGG Natural killer cell mediated cytotoxicity: HRAS/KRAS/NRAS → ARAF/BRAF/RAF1 (protein-protein, activation)
• KEGG Long-term potentiation: HRAS/KRAS/NRAS → ARAF/BRAF/RAF1 (protein-protein, activation)
• KEGG Neurotrophin signaling pathway: HRAS/KRAS/NRAS → BRAF/RAF1 (protein-protein, activation)
• KEGG Long-term depression: HRAS/KRAS/NRAS → ARAF/BRAF/RAF1 (protein-protein, activation)
• KEGG Regulation of actin cytoskeleton: HRAS/KRAS/MRAS/NRAS/RRAS/RRAS2 → ARAF/BRAF/MOS/RAF1 (protein-protein, activation)
• KEGG Insulin signaling pathway: HRAS/KRAS/NRAS → ARAF/BRAF/RAF1 (protein-protein, activation)
• KEGG MAPK signaling pathway: HRAS/KRAS/MRAS/NRAS/RRAS/RRAS2 → BRAF (protein-protein, activation)
• KEGG Progesterone-mediated oocyte maturation: KRAS → ARAF/BRAF/RAF1 (protein-protein, activation)
• KEGG Hepatitis C: HRAS/KRAS/NRAS → ARAF/BRAF/RAF1 (protein-protein, activation)
• KEGG Pathways in cancer: HRAS/KRAS/NRAS → ARAF/BRAF/RAF1 (protein-protein, activation)
• KEGG Colorectal cancer: KRAS → ARAF/BRAF/RAF1 (protein-protein, activation)
• KEGG Pancreatic cancer: KRAS → ARAF/BRAF/RAF1 (protein-protein, activation)
• KEGG Endometrial cancer: HRAS/KRAS/NRAS → ARAF/BRAF/RAF1 (protein-protein, activation)
• KEGG Endometrial cancer: KRAS → ARAF/BRAF/RAF1 (protein-protein, activation)
• KEGG Glioma: HRAS/KRAS/NRAS → ARAF/BRAF/RAF1 (protein-protein, activation)
• KEGG Glioma: HRAS/KRAS/NRAS → ARAF/BRAF/RAF1 (protein-protein, activation)
• KEGG Prostate cancer: HRAS/KRAS/NRAS → ARAF/BRAF/RAF1 (protein-protein, activation)
• KEGG Thyroid cancer: HRAS/KRAS/NRAS → BRAF (protein-protein, activation)
• KEGG Thyroid cancer: HRAS/KRAS/NRAS → BRAF (protein-protein, activation)
• KEGG Melanoma: HRAS/KRAS/NRAS → ARAF/BRAF/RAF1 (protein-protein, activation)
• KEGG Bladder cancer: HRAS/KRAS/NRAS → ARAF/BRAF/RAF1 (protein-protein, activation)
• KEGG Chronic myeloid leukemia: HRAS/KRAS/NRAS → ARAF/BRAF/RAF1 (protein-protein, activation)
• KEGG Acute myeloid leukemia: HRAS/KRAS/NRAS → ARAF/BRAF/RAF1 (protein-protein, activation)
• KEGG Acute myeloid leukemia: KRAS → ARAF/BRAF/RAF1 (protein-protein, activation)
• KEGG Non-small cell lung cancer: KRAS → ARAF/BRAF/RAF1 (protein-protein, activation)
• KEGG Non-small cell lung cancer: HRAS/KRAS/NRAS → ARAF/BRAF/RAF1 (protein-protein, activation)
• KEGG ErbB signaling pathway: HRAS/KRAS/NRAS → ARAF/BRAF/RAF1 (protein-protein, activation)
• KEGG Chemokine signaling pathway: HRAS/KRAS/NRAS → BRAF/RAF1 (protein-protein, activation)
• NCI Pathway Database PDGFR-beta signaling pathway: BRAF/14-3-3 (dimer) complex (BRAF-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, collaborate)
  Ory et al., Curr Biol 2003, Tran et al., J Biol Chem 2005, McKay et al., Proc Natl Acad Sci U S A 2009, Ritt et al., Mol Cell Biol 2010, Muslin et al., Cell 1996
  Evidence: assay, physical interaction
• NCI Pathway Database PDGFR-beta signaling pathway: RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → BRAF/14-3-3 complex (BRAF-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB) (modification, activates)
  Ory et al., Curr Biol 2003, Tran et al., J Biol Chem 2005, McKay et al., Proc Natl Acad Sci U S A 2009, Ritt et al., Mol Cell Biol 2010, Muslin et al., Cell 1996
  Evidence: assay, physical interaction
• WikiPathways MAPK Cascade: HRAS/NRAS/RRAS/KRAS → RAF1/ARAF/BRAF (activation)
• WikiPathways MAPK Signaling Pathway: MRAS/NRAS/KRAS → BRAF/RAF1/MOS (activation)
• WikiPathways Signaling Pathways in Glioblastoma: NRAS/KRAS/HRAS → ARAF/BRAF/RAF1 (mim-stimulation)
• WikiPathways BDNF-TrkB Signaling: NRAS/KRAS/HRAS → BRAF (activation)
• WikiPathways Chemokine signaling pathway: HRAS/KRAS/NRAS → BRAF/RAF1 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Ophid Interaction: BRAF — KRAS (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• STRING interaction: BRAF — KRAS (interaction, mapped from grid reactome kegg_pathways mint)
• STRING interaction: KRAS — BRAF (interaction, mapped from grid reactome kegg_pathways mint)

Text-mined interactions from Literome

Kim et al., Cancer Res 2004 (Cell Transformation, Neoplastic...) : Genechip analysis revealed numerous genes in which the regulation by oncogenic K-Ras did not require B-Raf
Ohtsuka et al., J Biol Chem 1996 : Rap1B enhanced the Ki-Ras stimulated B-Raf activity in an additive manner
Kuroda et al., J Biol Chem 1996 : Moreover, we found that Rap1B as well as Ki-Ras and Ha-Ras stimulate the B-Raf activity ... Bovine brain PS enhanced Ki-Ras stimulated B-Raf activity