Gene interactions and pathways from curated databases and text-mining

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CASP1 — CASP3

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Sun et al., Oncogene 1999 (Adenocarcinoma...) : The caspase inhibitors ( Z-DEVD-FMK and Z-VAD-FMK ) suppressed CD437 induced CPP32-like caspase activation and apoptosis in both cell lines
Selznick et al., J Neuropathol Exp Neurol 2000 : Caspase-3 deficiency, or pharmacological inhibition of caspase activity, prevented caspase-3 activation and blocked the appearance of apoptotic nuclear features but not Abeta induced neuronal death
Nakatsuka et al., Neurosci Lett 2000 (Ischemic Attack, Transient) : Although pro-caspase-3 was strongly detected, active caspase-3 was not detected before and until 84 h after 5-min ischemia
de Bilbao et al., Neuroscience 2000 (Facial Nerve Injuries) : Similar results were obtained in interleukin-1 beta converting enzyme-deficient and wild-type mice, indicating that the interleukin-1 beta converting enzyme may not be required for caspase 3 activation
De Saint Jean et al., Invest Ophthalmol Vis Sci 2000 : Apoptosis was confirmed by a cleavage of PARP and CPP32 , by caspase-8 activation , and by an index Hoechst/neutral red greater than one
Zhang et al., J Neurosci 2000 (Alzheimer Disease) : Caspase-3 induces neuronal apoptosis in 20 % of the cells, whereas caspase-7 or -8 do not induce apoptosis
Tomicic et al., Biochem Biophys Res Commun 2001 : Caspase-3- and caspase-9 mediated cleavage of Bcl-2 was efficiently blocked by caspase-3 ( zDEVD ) and caspase-9 ( zLEHD ) inhibitor, respectively
Kagawa et al., Clin Cancer Res 2001 : Caspase-3 deficiency, however, did not affect Bax induced levels of poly ( ADP-ribose ) polymerase cleavage, caspase-6 activation, and lamin B cleavage
Kumi-Diaka et al., Biol Cell 2000 (Carcinoma...) : The major findings of these studies are : i ) genistein inhibits growth and proliferation of both LNCaP and DU145 cells via apoptosis mainly, and necrosis at higher concentrations ; ii ) genistein induces activation and expression of caspase-3 ( CPP32 ) in both target cells ; iii ) genistein induced apoptosis and CPP32 activation could be significantly inhibited by the caspase-3 inhibitor, z-VAD-fmk ( N-benzyloxycarbonyl-Val-Asp-fluoromethyl-ketone ), thus confirming a mediator role of CPP32 in the genistein induced apoptotic pathway in the target cells
Stadelman et al., Brain Pathol 2001 (Fetal Death...) : Expression of apoptosis associated proteins p53, bcl-2, bax, and caspase-3/CPP32 , activation of caspase-3 , and modification of proteins via poly ( ADP-ribosyl ) ation was studied in pontosubicular neuron necrosis ( PSN ), a form of perinatal brain damage revealing the morphological hallmarks of neuronal apoptosis
Kwon et al., Exp Mol Med 2002 : Caspase-3 selective inhibitor, Ac-DEVD-CHO, prevented both the activation of caspase-3 and cleavage of poly ( ADP-ribose ) polymerase ( PARP )
Chandra et al., J Biol Chem 2003 : Here we present evidence that the mitochondrially localized active caspase-9 and -3 result mostly from translocation from the cytosol ( into the intermembrane space ) and partly from caspase mediated activation in the organelle rather than from the Apaf-1 mediated activation
Xu et al., Anticancer Res 2003 (Pancreatic Neoplasms) : Caspase-8 and -3 activities were increased by TRAIL treatment and apoptosis was largely blocked by caspase-8 and -3 inhibitors
Schoemaker et al., J Hepatol 2003 (Cholestasis...) : Apoptosis was determined by TUNEL staining, active caspase-3 staining, activation of caspase-8 , -9 and -3
Du et al., World J Gastroenterol 2003 (Carcinoma, Hepatocellular...) : The levels of CPP32-like protease activity in HepG2 and SMMC-7721 increased by 2.8- and 3.0-fold ( P < 0.05 ) at 48 h, and the levels of ICE-like protease activity also increased by 2.6- and 3.2-fold ( P < 0.05 ) respectively
Aouad et al., J Immunol 2004 : Caspase-3 is a component of Fas death inducing signaling complex in lipid rafts and its activity is required for complete caspase-8 activation during Fas mediated cell death
Yang et al., Nephron. Experimental nephrology 2004 (Necrosis) : Here we evaluate three caspase inhibitors : B-D-FMK ( pan caspase inhibitor ), Z-DEVDFMK ( predominantly Caspase-3 inhibitor ) and Z-VAD-FMK ( predominantly Caspase-1 and -3 inhibitor ) to ameliorate apoptosis induced by cisplatin in rat proximal tubular ( RPT ) cells ... Here we evaluate three caspase inhibitors : B-D-FMK ( pan caspase inhibitor ), Z-DEVDFMK ( predominantly Caspase-3 inhibitor ) and Z-VAD-FMK ( predominantly Caspase-1 and -3 inhibitor ) to ameliorate apoptosis induced by cisplatin in rat proximal tubular ( RPT ) cells
Kusunoki et al., BMC pharmacology 2004 (Arthritis, Rheumatoid) : Caspase-3 activity was increased by treatment with triptolide and was suppressed by caspase inhibitors
Messerli et al., Neoplasia (New York, N.Y.) 2004 (Glioma) : The specificity of this probe for caspase-1 is supported by various lines of evidence : 1 ) activation by purified caspase-1, but not another caspase in vitro ; 2 ) activation of the probe by infection of cells with a herpes simplex virus amplicon vector ( HGC-ICE-lacZ ) expressing a catalytically active caspase-1-lacZ fusion protein; 3 ) inhibition of HGC-ICE-lacZ vector induced activation of the probe by coincubation with the caspase-1 inhibitor YVAD-cmk, but not with a caspase-3 inhibitor ; and 4 ) activation of the probe following standard methods of inducing apoptosis with staurosporine, ganciclovir, or ionizing radiation in culture
Guo et al., Cell Death Differ 2006 : Caspase-1 activation of caspase-6 in human apoptotic neurons
Liszewska et al., Prostaglandins Other Lipid Mediat 2005 : Treatment of luteal cells with P4 and PGE2 for 24 h decreased ( P < 0.05 ) level of active caspase-3 while aminoglutethimide ( P < 0.05 ), spermine NONOate ( P < 0.05 ), and staurosporine ( P < 0.001 ) increased caspase-3 activity in the cells
Shankar et al., J Neurosci 2006 : Rhgas6 and caspase inhibitors also reduced active caspase-3 immunoreactivity relative to TNFalpha-only treated cultures
Nakadai et al., Toxicology 2006 : Chlorpyrifos also induced an increase of intracellular active caspase-3 in U937 cells in a dose dependent manner, and a caspase-3 inhibitor, Z-DEVD-FMK, significantly inhibited the chlorpyrifos induced apoptosis
Yang et al., Apoptosis 2006 : Caspase-3 mediated-feedback and activation of caspase-8 and -9 in MCF-7/C3 cells is further supported by an increase in the cleavage of caspase-8 and 9 substrates and cytochrome c release
Koo et al., Am J Chin Med 2007 : Caspase-3 activation and subsequent apoptotic cell death in MGG treated cells were partially blocked by the caspase-3 inhibitor, Z-DEVD-FMK
Ikeda et al., Exp Cell Res 2007 : Caspase-3 activation is also induced, but the caspase inhibitor, Z-VAD-FMK, does not block RASSF6 mediated apoptosis
Wong et al., Biochim Biophys Acta 2007 : Caspase-3 is activated by cleavage of caspase-8 and caspase-9
Denault et al., Biochem J 2007 : Caspase 3 attenuates XIAP ( X-linked inhibitor of apoptosis protein ) -mediated inhibition of caspase 9
Feng et al., J Huazhong Univ Sci Technolog Med Sci 2007 : Caspase-3 inhibitors can suppress caspase-3 activity and reduce the apoptosis rate significantly
Li et al., Toxicology 2007 : DDVP also induced an increase of intracellular active caspase-3 in NK-92CI in a dose- and time dependent manner, and a caspase-3 inhibitor, Z-DEVD-FMK, significantly inhibited DDVP induced apoptosis, suggesting that this apoptosis is partially mediated by activation of intracellular caspase-3
Wei et al., Zhonghua Xue Ye Xue Za Zhi 2007 : The caspase-3 activity was markedly enhanced, and the active caspase-3 in K562/ADM cells increased by about 40 % compared to liposome alone and non silencing controls
Audo et al., Arthritis Res Ther 2007 (Arthritis, Rheumatoid) : Caspase 3 , a key mediator of apoptosis, was not activated in celecoxib treated RA FLSs, and the presence of specific caspase 3 or pan-caspase inhibitors did not affect celecoxib induced cell death
Scarlatti et al., Cell Death Differ 2008 (Breast Neoplasms) : Here we show that resveratrol arrests cell proliferation, triggers death and decreases the number of colonies of cells that are sensitive to caspase-3 dependent apoptosis ( MCF-7 casp-3 ) and also those that are unresponsive to it ( MCF-7vc )
Li et al., Toxicology 2009 : Chlorpyrifos also induced an increase in intracellular active caspase-3 in Jurkat T cells in a dose- and time dependent manner, and a caspase-3 inhibitor, Z-DEVD-FMK, significantly inhibited chlorpyrifos induced apoptosis
Tang et al., Oncol Rep 2009 (Adenocarcinoma...) : Caspase-9 and -3 inhibitors almost completely suppressed HCT induced caspase-9 and -3 activities
Li et al., Arch Toxicol 2011 (Necrosis) : DNA fragmentation was detected when cells were treated with 0.5, 1, or 2 µM ziram for 24 h. Ziram also induced an increase in intracellular active caspase-3 in U937 cells in a dose dependent manner, and a caspase-3 inhibitor, Z-DEVD-FMK, significantly inhibited the ziram induced apoptosis
Xiao et al., Apoptosis 2011 : Caspase-3 activity was 10-fold higher in myotubes compared to myoblasts, and Stsp caused a significant caspase-3 induction in both
Jeyasuria et al., Biol Reprod 2011 : The IAP family members are the only endogenous inhibitors of active caspase 3 , and MCL1 limits activation of caspase 3 by suppressing proapoptotic signaling
Fang et al., J Immunol 2011 (Disease Resistance...) : Caspase-1 activation was partially impaired in NLRP3 ( -/- ) macrophages, whereas knockdown and knockout of AIM2 resulted in a clear decrease in caspase-1 activation in response to S. pneumoniae
Aras et al., Brain Res 2012 (Gliosis) : Reactive neonatal and adult astrocytes demonstrated an increase in total caspase activity with a corresponding increase in the expression of active caspase-3 in the absence of cell death
Edgington et al., Chem Biol 2012 : We also demonstrate that caspase-6 activation does not require active caspase-3/-7 , suggesting that it may autoactivate or be cleaved by other proteases
Nelson et al., Crit Care Med 2012 (Muscular Atrophy) : These findings support our hypothesis that a regulatory calpain/caspase-3 cross-talk exists whereby calpain can promote caspase-3 activation and active caspase-3 can enhance calpain activity in diaphragm muscle during prolonged mechanical ventilation
Chan et al., J Virol 2012 : However, HCMV infection does induce a temporal activation of caspase 3, with only a low level of active caspase 3 being observed after the 48-h viability checkpoint
LaRock et al., Cell Host Microbe 2012 : Caspase-1 activation antagonizes Yersinia survival in vivo, and consequently YopM inhibition of caspase-1 is required for Yersinia pathogenesis
Wu et al., Food Chem Toxicol 2013 : Caspase-3 inhibitor also efficiently blocked CD95 ( APO-1/CD95 ) and Bax expression, caspase-3 activation and PARP cleavage, whereas antioxidant N-acetyl-l-cysteine, AMPK inhibitor and AMPK siRNA effectively blocked the AMPK phosphorylation
Enari et al., Nature 1996 : The CPP32 inhibitor inhibited ICE- or CPP32 induced apoptosis in the cell-free system, whereas the ICE-inhibitor only inhibited ICE induced apoptosis
Armstrong et al., J Biol Chem 1996 : Fas induced activation of the cell death related protease CPP32 Is inhibited by Bcl-2 and by ICE family protease inhibitors
Armstrong et al., J Neurosci 1997 (Necrosis) : CPP32 activation requires macromolecular synthesis and CED3/ICE protease activity
Wright et al., J Exp Med 1997 (Lymphoma) : Only the caspase inhibitors, however, prevented activation of CPP32-like activity as revealed by cleavage of the synthetic substrate, DEVD-pNa, by cell cytosols, and also by in vivo cleavage of poly ( ADP-ribosyl ) polymerase, a known substrate of CPP32
Wang et al., Cell 1998 (Shock, Septic) : Murine caspase-11 , an ICE interacting protease, is essential for the activation of ICE ... Furthermore, we found that pro-caspase-11 physically interacts with pro-ICE in cells, and the expression of casp-11 is essential for activation of ICE ... Our data suggest that caspase-11 is a component of ICE complex and is required for the activation of ICE
Deveraux et al., EMBO J 1998 : In contrast, these IAP family proteins did not prevent caspase-8 induced proteolytic activation of pro-caspase-3 ; however, they subsequently inhibited active caspase-3 directly, thus blocking downstream apoptotic events such as further activation of caspases