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CAV1 — EGF

Text-mined interactions from Literome

Wang et al., J Biol Chem 2002 : Consistently, depletion of ganglioside both increases EGFR phosphorylation and prevents the EGF induced tyrosine phosphorylation of caveolin-1 ... These studies suggest that GM3 modulates the caveolin-1/EGFR association and is critical for the EGF induced tyrosine phosphorylation of caveolin-1 that is associated with its inhibition of EGFR activation
Kim et al., Exp Cell Res 2002 (Carcinoma, Squamous Cell) : Previous studies have shown that EGF can induce the tyrosine phosphorylation of caveolin-1 in murine fibroblasts following ErbB1 ( EGF receptor ) mutation or overexpression, but the cell signaling events linking EGF action with caveolin phosphorylation are not fully established ... In all cases, EGF treatment induced the tyrosine phosphorylation of caveolin-1 in a time- and EGF dose dependent manner, and immunoblotting analysis revealed that this phosphorylation occurred at tyrosine-14 ... The EGF dependent phosphorylation of caveolin-1 was observed at low temperatures ( 4 degrees C ) and was enhanced by caveolae disrupting agents ( cyclodextrin ), suggesting that this EGF dependent system is in a low temperature-stable arrangement that allows for their interaction under conditions where mobility in the membrane is altered ... We observed that EGF and HB-EGF, but not heregulin, promoted caveolin-1 phosphorylation in A431 cells, suggesting that these responses are linked to EGF receptor activation and not solely occurring via the activation of other endogenous ErbB family members ... In addition, the EGF induced phosphorylation of caveolin-1 in A431 cells was blocked by the Src kinase antagonists PP1 and PP2, but not by the MEK inhibitor PD98059, the phosphoinositide 3-kinase inhibitors LY294002 and wortmannin, or cytoskeleton disrupting agents, such as cytochalasin D, colchicine, and nocadazole
Sexton et al., Exp Eye Res 2004 : EGF stimulated phosphorylation of caveolin-1 in human A431 cells but not lens cells
Lu et al., Cancer Cell 2003 (Neoplasm Metastasis) : We propose that EGF induced negative regulation of caveolin-1 plays a central role in the complex cellular changes leading to metastasis
Lu et al., Cell cycle (Georgetown, Tex.) 2004 (Neoplasms) : In response to EGF, tumor cells overexpressing EGF receptor display GSK-3beta independent activation of beta-catenin, which may result from a combination of effects-EGF stimulated, caveolin-1 dependent internalization of E-cadherin, resulting in release of beta-catenin from cell-cell contacts, and EGF induced downregulation of caveolin-1 , relieving the inhibition of signaling molecules sequestered by caveolin-1 at caveolae
Perdue et al., Exp Eye Res 2006 : The lens epithelial cells expressed epidermal growth factor (EGF) receptor and were responsive to EGF mediated cell proliferation, but they did not show EGF dependent caveolin-1 tyrosine phosphorylation
Gosens et al., Am J Physiol Lung Cell Mol Physiol 2007 : EGF induced concomitant phosphorylation of caveolin-1 and p42/p44 MAP kinase ; however, EGF did not promote the localization of p42/p44 MAP kinase, Grb2, or Raf-1 to caveolae
Park et al., Am J Physiol Cell Physiol 2009 : The results revealed that EGF increased Src, caveolin-1 , focal adhesion kinase ( FAK ), Akt, and extracellular signal regulated kinase-1/2 ( ERK ) phosphorylation levels
Orlichenko et al., Mol Biol Cell 2009 : Caveolin-1 and E-cadherin closely associated at cell borders and in internalized structures upon stimulation with EGF
Boscher et al., Mol Biol Cell 2013 (Breast Neoplasms...) : Similarly, caveolin-1/galectin-3 dependent EGF signaling induces motility, peripheral actin ruffling, and RhoA activation in MDA-MB-231 human breast carcinoma cells, but not HeLa cells