Gene interactions and pathways from curated databases and text-mining

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CCL11 — IL4

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: CCL11 → IL4 (increases) Fritz et al., J Immunol 2006*
    Evidence: IL-4 has been documented to regulate the expression of eotaxin-1 (41), eotaxin-2 (42), and eotaxin-3 (34) in endothelial cells and fibroblasts in a STAT6-dependent manner (42, 43, 44, 45). IL-4 signal transduction includes activation of STAT6 (46, 47, 48, 49, 50).
  • OpenBEL Selventa BEL large corpus: CCL11 → IL4 (increases) Li et al., J Immunol 1999*
    Evidence: Eotaxin expression by human dermal fibroblasts (13) and lung epithelial cells (14) was stimulated by IFN-g in the presence of IL-1 and TNF-a, while eotaxin produced by human fibroblasts was induced by IL-4 (15).

Text-mined interactions from Literome

Devouassoux et al., J Immunol 1999 (Asthma...) : Eotaxin alone had no effect on basophil IL-4 production, but further increased allergen stimulated IL-4 expression ... Eotaxin also enhanced IL-4 release from purified basophils 2- to 4-fold, as determined by ELISA ( p < 0.01 )
Katayama et al., Am J Respir Cell Mol Biol 2002 : Eotaxin was induced by tumor necrosis factor (TNF)-alpha or interleukin (IL)-4 and was drastically increased by their combination
Peng et al., Am J Respir Crit Care Med 2004 (Asthma...) : Eotaxin release induced by IL-13 or IL-4 ( 10 ng/ml ) was reduced by 81 +/- 4 and 75 +/- 7 %, respectively, in cells transfected with antisense ODNs ( p < 0.001 ), but not with a sense ODN or a scrambled ODN. Eotaxin release induced by IL-1beta was unaffected by STAT6 antisense ODN ( p > 0.05 )
Kobayashi et al., Ann Allergy Asthma Immunol 2004 : Eotaxin-1 and eotaxin-3, but not eotaxin-2, mRNA expressions were induced by stimulation with interleukin (IL) 13 or IL-4
Rokudai et al., Biol Pharm Bull 2006 (Asthma...) : Differential regulation of eotaxin-1/CCL11 and eotaxin-3/CCL26 production by the TNF-alpha and IL-4 stimulated human lung fibroblast
Niimi et al., J Immunol 2007 : Synthetic dsRNA, polyinosinic-cystidic acid ( poly ( I:C ) ), induced the synthesis of eosinophilic chemokines, eotaxin-1/CCL11 and RANTES/CCL5, from primary cultures of human BSMC, and IL-4 increased synergistically the synthesis of poly ( I:C ) -induced CCL11
Stevenson et al., J Leukoc Biol 2009 : CCL11 blocks IL-4 and GM-CSF signaling in hematopoietic cells and hinders dendritic cell differentiation via suppressor of cytokine signaling expression
Dawson et al., Infect Immun 2009 (Ascariasis...) : IL4 induced CCL11 , CCL17, CCL22, and CCL26 mRNA, and ATRA increased the basal and IL4 stimulated expression of CCL17 and CCL22
Matsukura et al., Clin Exp Allergy 2010 (Asthma) : TGF-beta alone did not increase the expression of chemokine mRNAs, but enhanced the induction of only CCL11 by IL-4 or IL-13 among CCR3 ligands ... Activity of the CCL11 promoter was stimulated by IL-4 , and this activity was enhanced by TGF-beta ... Pretreatment with an inhibitor of NF-kappaB and glucocorticoid fluticasone propionate significantly inhibited the expression of CCL11 mRNA induced by IL-4 plus TGF-beta, indicating the importance of NF-kappaB in the cooperative activation of CCL11 transcription by TGF-beta and IL-4
Yoshihisa et al., J Invest Dermatol 2011 (Dermatitis, Allergic Contact...) : Eotaxin expression was induced by IL-4 stimulation in fibroblasts in MIF Tg mice, but not in MIF KO mice
Zhou et al., J Immunol 2012 (Asthma...) : MAPK regulation of IL-4/IL-13 receptors contributes to the synergistic increase in CCL11/eotaxin-1 in response to TGF-ß1 and IL-13 in human airway fibroblasts
Hosokawa et al., Cell Physiol Biochem 2013 : Moreover, we examined the effects of EGCG on CCL11 production in HGFs. Methods and Results : ELISA analysis disclosed that interleukin (IL)-4 synergistically enhanced CCL11 production in IL-1ß or tumor necrosis factor (TNF)-a stimulated HGFs. EGCG prevented IL-1ß/ IL-4 or TNF-a/IL-4 mediated CCL11 production in a concentration dependent manner