Gene interactions and pathways from curated databases and text-mining

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CCL2 — PTK2

Text-mined interactions from Literome

Bian et al., Exp Eye Res 2003 (Translocation, Genetic) : These results suggest that activation of DEX-sensitive, CSA-resistant MEK/ERK and p38 pathways, and activation of NF-kappaB, PKC, and PTK are essential for IL-8 and MCP-1 expression by hRPE cells
Zeng et al., Acta Pharmacol Sin 2005 : Inhibitors of PKC ( calphostin C, 50-500 nmol/L and RO-31-8220, 10-100 nmol/L ), CaM ( W7, 28-280 micromol/L ), ERK1/2 MAPK ( PD 98059, 2-20 micromol/L ), p38 MAPK ( SB 203580, 0.6-6 micromol/L ), JNK MAPK ( curcumin, 2-10 micromol/L ), and NF-kappaB ( PDTC, 10-100 nmol/L ) markedly reduced Hcy 100 micromol/L induced production of MCP-1 and IL-8 in human cultured whole blood, but the inhibitors of PTK ( genistein, 2.6-26 micromol/L and tyrphostin, 0.5-5 micromol/L ) had no obvious effect on MCP-1 and IL-8 production
Wang et al., Zhongguo Shi Yan Xue Ye Xue Za Zhi 2006 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : This study was aimed to explore the expression of MIP-1alpha, MCP-1 and their receptors CCR-1, CCR-2 in bcr/abl fusion gene positive CML cells, and to study the effects of P210 ( bcr/abl ) fusion protein tyrosine kinase on expression of MIP-1alpha, MCP-1 and their receptors CCR-1, CCR-2 mRNAs in chronic myeloid leukemia cells
Rovin et al., Kidney Int 1994 : The structurally distinct protein tyrosine kinase ( PTK ) inhibitors genistein, herbimycin A, and tyrphostin each caused a dose dependent inhibition of the effects of IL-1 on mesangial MCP-1 activity