Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Pervin et al., Cancer Res 2007 (Breast Neoplasms...) : Critical components in the translational machinery, such as phosphorylated mammalian target of rapamycin (mTOR) and its downstream targets, phosphorylated eukaryotic translation initiation factor and p70 S6 kinase, were up-regulated following NO treatment, and inhibition of mTOR with rapamycin attenuated NO induced increase of cyclin D1 and ODC
Averous et al., Oncogene 2008 (Breast Neoplasms) : Regulation of cyclin D1 expression by mTORC1 signaling requires eukaryotic initiation factor 4E-binding protein 1
Dal Col et al., Blood 2008 (Lymphoma, Mantle-Cell) : Intriguingly, mTOR inhibition affected cyclin D1 proteolysis only in MCL cells in which GSK-3 is under the direct control of mTOR, suggesting that different MCL subsets could be differently responsive to mTOR inhibition
Drakos et al., Leukemia 2009 (Lymphoma, Mantle-Cell) : As mTOR signaling is activated in MCL and may control cyclin D1 levels, we show that p53 activation may downregulate the AKT/mTOR pathway through a mechanism involving AMP kinase (AMPK)
Kuang et al., Biochem Biophys Res Commun 2009 (Lymphoma...) : Here, we show that inhibition of mTOR signaling with its specific inhibitor, rapamycin, suppresses normal thymocyte DNA synthesis by downregulating 4EBP1, but not S6K, and that 4EBP1 phosphorylation and cyclin D1 expression are coordinately increased in Atm-/- thymocytes
Chen et al., Cancer prevention research (Philadelphia, Pa.) 2010 (Neoplasms) : Cryptotanshinone inhibits cancer cell proliferation by suppressing Mammalian target of rapamycin mediated cyclin D1 expression and Rb phosphorylation
Parrales et al., Cell Signal 2013 : Since Akt functions as an upstream activator of mechanistic target of rapamycin complex 1 ( mTORC1 ) and is also a downstream target for mTORC2, the aim of this work was to determine whether mTOR is involved in thrombin induced RPE cell proliferation by regulating cyclin D1 expression in immortalized rat RPE-J cell line