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CD44 — MAPK7

Text-mined interactions from Literome

Monaghan et al., J Pathol 2000 (Astrocytoma...) : Up-regulation of CD44 by EGF is also prevented by the transcriptional inhibitor actinomycin D ( 5 microg/ml ) and by blocking the MAP kinase ( MAPK ) pathway using the MEK inibitor U0126 ( 100 microM )
Fujita et al., FEBS Lett 2002 : Engagement of CD44 either by its natural ligand hyaluronan or a specific antibody on a cell line induced tyrosine phosphorylation and activation of focal adhesion kinase ( FAK ), which then associated with phosphatidylinositol 3-kinase (PI3K) and activated mitogen activated protein kinase at its downstream
Gee et al., J Immunol 2002 : We demonstrate the involvement , at least in part, of p38 MAPK in TNF-alpha induced CD44 expression in both monocytes and promonocytic THP-1 cells
Roscic-Mrkic et al., Blood 2003 : By specifically reducing CD44 expression using RNA interference we were able to demonstrate that the p44/p42 MAPK activation by RANTES requires a high level of CD44 expression ... Here we show that silencing of CD44 in HeLa-CD4 cells prevents the activation of p44/p42 MAPK and leads to a substantial reduction in HIV-1 infectivity enhancement by RANTES
Gee et al., J Biol Chem 2003 : Furthermore, p38 mitogen activated protein kinase ( MAPK ) activation was required for LPS- and TNF-alpha induced, but not IL-10 induced, CD44-HA binding in normal monocytes ... Subsequently, TNF-alpha mediated p38 MAPK activation induced sialidase activity and CD44-HA binding ... Taken together, our results suggest that TNF-alpha induced p38 MAPK activation may regulate the induction of functionally active HA-binding form of CD44 by activating sialidase in LPS stimulated human monocytic cells
Singh et al., Glycobiology 2006 (Colonic Neoplasms) : Peanut lectin stimulates proliferation of colon cancer cells by interaction with glycosylated CD44v6 isoforms and consequential activation of c-Met and MAPK : functional implications for disease associated glycosylation changes
Kim et al., Mol Immunol 2008 (Dermatitis, Allergic Contact...) : CD44 mediated effect of antigen on phosphorylation of ERK, p38MAPK , ROS production, secretion of beta-hexosaminidase, and histamine release