Gene interactions and pathways from curated databases and text-mining

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CD4 — CD69

Text-mined interactions from Literome

Zhou et al., J Immunol 2000 : When CD3 and CD5 on CD4+CD8+ thymocytes in culture were coligated, they lost CD8, down-regulated CD4 expression, and induced CD69 expression, yielding a CD4+ ( dull ) CD8-CD69+ population
Heinzelmann et al., Immunopharmacology 2000 : Analysis of leukocyte subsets demonstrated that CD4 ( + ) T-cells, CD8 ( + ) T-cell, CD19 ( + ) B-cells, CD56 ( + ) natural killer ( NK ) -cells, and CD14 ( + ) monocytes increased the expression of CD69 after stimulation with LPS
Brogan et al., Arthritis Rheum 2004 (Vasculitis) : Coculture of purified T cells with class II MHC positive HUVECs and either TSST-1 or SEB resulted in V ( beta ) -restricted CD69 up-regulation by CD4 and CD8 cells ( V ( beta ) 2 activation for TSST-1 ; V ( beta ) 3, V ( beta ) 5.1, and V ( beta ) 12 activation for SEB )
Meier et al., Clin Nephrol 2005 (Kidney Failure, Chronic) : CD4+ T cell early activation ( CD69 , CD25 ), interleukin-2 (IL-2)/IL-2 receptor (IL-2R) system, and proliferation capacity of CD69+/CD4+ T cells were assessed ex vivo after blood draw sampling, in culture conditions and after phytohemagglutinin ( PHA ) stimulation
Kim et al., PloS one 2013 : Curcumin not merely blocks, but regulates CD2/CD3/CD28 initiated CD4 ( + ) T cell activation by augmenting CD69 , CCR7, L-selectin and TGF-ß1 expression followed by regulatory T cell generation