Gene interactions and pathways from curated databases and text-mining

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CD79A — MAPK10

Text-mined interactions from Literome

Kawauchi et al., Int J Hematol 2002 (Leukemia, Lymphocytic, Chronic, B-Cell...) : In B-CLL cells, BCR cross linking neither induced activation nor enhanced the activities of Lyn, Syk, p21ras, JNK, p38 MAPK , or Akt kinases, whereas p38 MAPK and Akt were constitutively active
Ke et al., J Biol Chem 2006 (Lymphoma, B-Cell...) : BCR induced MAPK activation was modest and transient with a small increase in egr-1 expression in normal immature B cells consistent with their inability to proliferate in response to BCR cross linking
Chu et al., Cancer Res 2007 (Cell Transformation, Neoplastic...) : BCR/ABL expression results in enhanced Ras and Akt activity but reduced mitogen activated protein kinase activity in human hematopoietic cells, which is reversed by BCR/ABL-Y177 mutation
Gross et al., J Immunol 2009 : Wild-type mature follicular B cells were less sensitive to BCR stimulation than were immature transitional stage 1 B cells with regard to BCR induced calcium elevation and ERK MAPK activation
Modi et al., Leukemia 2011 (Cell Transformation, Neoplastic...) : We conclude that inhibition of Grb2 expression demonstrates an important role in BCR-ABL mediated MAPK activation and transformation of primary human hematopoietic cells.These results support further investigation of downstream effectors of Grb2 mediated signals and targeting of Grb2 interactions in the treatment of CML
Salmon et al., J Immunol 1997 : We conclude that the activation of p38 MAPK and MAPKAP kinase-2 by cross linking of the TCR, BCR , Fas, or CD40 was not correlated with their roles in regulating lymphocyte survival, and that suppression of kinase activity did not inhibit the induction of apoptosis
Graves et al., J Immunol 1998 (Lymphoma, B-Cell) : To determine the role of p38 MAPK activation in BCR- and Fas induced apoptosis, we employed SB203580, a specific inhibitor of p38 MAPK
Jiang et al., J Exp Med 1998 : BCR cross linking in the chicken DT40 B cell line also activates three distinct mitogen activated protein kinases ( MAPKs ) : extracellular signal regulated kinase ( ERK ) 2, c-jun NH2-terminal kinase ( JNK ) 1, and p38 MAPK ... However, BCR mediated p38 MAPK activation was abolished in Lyn/Syk double deficient cells, demonstrating that either Lyn or Syk alone may be sufficient to activate p38 MAPK