◀ Back to CD79A
CD79A — CD79B
Pathways - manually collected, often from reviews:
-
BioCarta ctcf: first multivalent nuclear factor:
B-cell antigen/BCR complex complex (BCR-CD79A-CD79B)
→
pten, mmac1 (PTEN)
(modification, activates)
-
BioCarta bcr signaling pathway:
B-cell antigen/BCR/CD79A/CD79B/Btk/LYN/BLNK complex (BCR-CD79A-CD79B-BTK-LYN-BLNK)
→
SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1)
(modification, activates)
-
BioCarta bcr signaling pathway:
LYN
→
B-cell antigen/BCR/CD79A/CD79B/Btk/LYN/BLNK complex (BCR-CD79A-CD79B-BTK-LYN-BLNK)
(modification, collaborate)
-
BioCarta bcr signaling pathway:
LYN
→
B-cell antigen/BCR complex complex (BCR-CD79A-CD79B)
(modification, collaborate)
-
BioCarta bcr signaling pathway:
B-cell antigen/BCR/CD79A/CD79B/Btk/LYN/BLNK complex (BCR-CD79A-CD79B-BTK-LYN-BLNK)
→
BLNK
(modification, collaborate)
-
BioCarta bcr signaling pathway:
B-cell antigen/BCR/CD79A/CD79B/Btk/LYN/BLNK complex (BCR-CD79A-CD79B-BTK-LYN-BLNK)
→
BTK
(modification, collaborate)
-
BioCarta bcr signaling pathway:
B-cell antigen/BCR/CD79A/CD79B/Btk/LYN/BLNK complex (BCR-CD79A-CD79B-BTK-LYN-BLNK)
→
B-cell antigen/BCR complex complex (BCR-CD79A-CD79B)
(modification, collaborate)
-
BioCarta bcr signaling pathway:
BLNK
→
B-cell antigen/BCR complex complex (BCR-CD79A-CD79B)
(modification, collaborate)
-
BioCarta bcr signaling pathway:
BTK
→
B-cell antigen/BCR complex complex (BCR-CD79A-CD79B)
(modification, collaborate)
-
BioCarta ctcf: first multivalent nuclear factor:
B-cell antigen/BCR complex complex (BCR-CD79A-CD79B)
→
BCR complex complex (BCR-CD79A-CD79B)
(modification, collaborate)
-
BioCarta bcr signaling pathway:
B-cell antigen/BCR complex complex (BCR-CD79A-CD79B)
→
BCR complex complex (BCR-CD79A-CD79B)
(modification, collaborate)
-
NCI Pathway Database BCR signaling pathway:
SHP1 (PTPN6)
→
B-cell antigen/BCR complex/LYN complex (LYN-CD79B-CD79A)
(modification, inhibits)
Pao et al., J Immunol 1997
Evidence: assay
-
NCI Pathway Database BCR signaling pathway:
SHP1 (PTPN6)
→
B-cell antigen/BCR complex/LYN/SYK complex (LYN-SYK-CD79B-CD79A)
(modification, inhibits)
Pao et al., J Immunol 1997
Evidence: assay
-
NCI Pathway Database BCR signaling pathway:
SYK (SYK)
→
B-cell antigen/BCR complex/LYN complex (LYN-CD79B-CD79A)
(modification, collaborate)
Pao et al., J Immunol 1997
Evidence: assay
-
NCI Pathway Database BCR signaling pathway:
SYK (SYK)
→
B-cell antigen/BCR complex/LYN/SYK complex (LYN-SYK-CD79B-CD79A)
(modification, collaborate)
Pao et al., J Immunol 1997
Evidence: assay
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/LYN complex (LYN-CD79B-CD79A)
→
B-cell antigen/BCR complex/LYN/SYK complex (LYN-SYK-CD79B-CD79A)
(modification, collaborate)
Pao et al., J Immunol 1997
Evidence: assay
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2/CD72 complex (BTK-PLCG2-CD72-SYK-CD79B-LYN-CD79A-BLNK)
→
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK)
(modification, collaborate)
Adachi et al., J Biol Chem 2001
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2/CD72 complex (BTK-PLCG2-CD72-SYK-CD79B-LYN-CD79A-BLNK)
→
CD72/SHP1 complex (CD72-PTPN6)
(modification, collaborate)
Adachi et al., J Biol Chem 2001
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2/CD72 complex (BTK-PLCG2-CD72-SYK-CD79B-LYN-CD79A-BLNK)
→
SHP1 (PTPN6)
(modification, collaborate)
Adachi et al., J Biol Chem 2001
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK)
→
CD72/SHP1 complex (CD72-PTPN6)
(modification, collaborate)
Adachi et al., J Biol Chem 2001
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK)
→
SHP1 (PTPN6)
(modification, collaborate)
Adachi et al., J Biol Chem 2001
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex complex (CD79B-CD79A)
→
BCR complex complex (CD79A-CD79B)
(modification, collaborate)
-
NCI Pathway Database BCR signaling pathway:
SAB (SH3BP5)
→
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK)
(modification, inhibits)
Yamadori et al., Proc Natl Acad Sci U S A 1999, Baba et al., Proc Natl Acad Sci U S A 2001, Liu et al., Nat Immunol 2001, Rodriguez et al., Biochem J 2003
-
NCI Pathway Database BCR signaling pathway:
SAB (SH3BP5)
→
B-cell antigen/BCR complex/LYN/SYK/BLNK complex (LYN-SYK-BLNK-CD79B-CD79A)
(modification, inhibits)
Yamadori et al., Proc Natl Acad Sci U S A 1999, Baba et al., Proc Natl Acad Sci U S A 2001, Liu et al., Nat Immunol 2001, Rodriguez et al., Biochem J 2003
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK)
→
PLCgamma2 (PLCG2)
(modification, collaborate)
Yamadori et al., Proc Natl Acad Sci U S A 1999, Baba et al., Proc Natl Acad Sci U S A 2001, Liu et al., Nat Immunol 2001, Rodriguez et al., Biochem J 2003
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK)
→
B-cell antigen/BCR complex/LYN/SYK/BLNK complex (LYN-SYK-BLNK-CD79B-CD79A)
(modification, collaborate)
Yamadori et al., Proc Natl Acad Sci U S A 1999, Baba et al., Proc Natl Acad Sci U S A 2001, Liu et al., Nat Immunol 2001, Rodriguez et al., Biochem J 2003
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK)
→
Btk (BTK)
(modification, collaborate)
Yamadori et al., Proc Natl Acad Sci U S A 1999, Baba et al., Proc Natl Acad Sci U S A 2001, Liu et al., Nat Immunol 2001, Rodriguez et al., Biochem J 2003
-
NCI Pathway Database BCR signaling pathway:
PLCgamma2 (PLCG2)
→
B-cell antigen/BCR complex/LYN/SYK/BLNK complex (LYN-SYK-BLNK-CD79B-CD79A)
(modification, collaborate)
Yamadori et al., Proc Natl Acad Sci U S A 1999, Baba et al., Proc Natl Acad Sci U S A 2001, Liu et al., Nat Immunol 2001, Rodriguez et al., Biochem J 2003
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/LYN/SYK/BLNK complex (LYN-SYK-BLNK-CD79B-CD79A)
→
Btk (BTK)
(modification, collaborate)
Yamadori et al., Proc Natl Acad Sci U S A 1999, Baba et al., Proc Natl Acad Sci U S A 2001, Liu et al., Nat Immunol 2001, Rodriguez et al., Biochem J 2003
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/LYN/SYK/BLNK complex (LYN-SYK-BLNK-CD79B-CD79A)
→
IBtk (IBTK)
(modification, collaborate)
Yamadori et al., Proc Natl Acad Sci U S A 1999, Baba et al., Proc Natl Acad Sci U S A 2001, Liu et al., Nat Immunol 2001, Rodriguez et al., Biochem J 2003
-
NCI Pathway Database BCR signaling pathway:
CD19 (CD19)
→
B-cell antigen/BCR complex/LYN/SYK complex (LYN-SYK-CD79B-CD79A)
(modification, collaborate)
Okada et al., Immunity 2000, Weng et al., J Biol Chem 1994
Evidence: assay, physical interaction
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/LYN/SYK complex (LYN-SYK-CD79B-CD79A)
→
PI3K/BCAP/CD19 complex (CD19-PIK3CA-PIK3R1)
(modification, activates)
Okada et al., Immunity 2000, Weng et al., J Biol Chem 1994
Evidence: assay, physical interaction
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/LYN/SYK complex (LYN-SYK-CD79B-CD79A)
→
VAV2 (VAV2)
(modification, activates)
Okada et al., Immunity 2000, Weng et al., J Biol Chem 1994
Evidence: assay, physical interaction
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/LYN/SYK complex (LYN-SYK-CD79B-CD79A)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, activates)
Okada et al., Immunity 2000, Weng et al., J Biol Chem 1994
Evidence: assay, physical interaction
-
NCI Pathway Database BCR signaling pathway:
RasGAP (RASA1)
→
B-cell antigen/BCR complex/FcgammaRIIB complex (FCGR2B-CD79B-CD79A)
(modification, collaborate)
-
NCI Pathway Database BCR signaling pathway:
Csk (CSK)
→
B-cell antigen/BCR complex/FcgammaRIIB complex (FCGR2B-CD79B-CD79A)
(modification, collaborate)
-
NCI Pathway Database BCR signaling pathway:
BLNK (BLNK)
→
B-cell antigen/BCR complex/LYN/SYK complex (LYN-SYK-CD79B-CD79A)
(modification, collaborate)
Kabak et al., Mol Cell Biol 2002
Evidence: physical interaction
-
NCI Pathway Database BCR signaling pathway:
BLNK (BLNK)
→
B-cell antigen/BCR complex/LYN/SYK/BLNK complex (LYN-SYK-BLNK-CD79B-CD79A)
(modification, collaborate)
Kabak et al., Mol Cell Biol 2002
Evidence: physical interaction
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/LYN/SYK complex (LYN-SYK-CD79B-CD79A)
→
B-cell antigen/BCR complex/LYN/SYK/BLNK complex (LYN-SYK-BLNK-CD79B-CD79A)
(modification, collaborate)
Kabak et al., Mol Cell Biol 2002
Evidence: physical interaction
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2/CD72 complex (BTK-PLCG2-CD72-SYK-CD79B-LYN-CD79A-BLNK)
→
CD72 (CD72)
(modification, collaborate)
Fusaki et al., Eur J Immunol 2000
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2/CD72 complex (BTK-PLCG2-CD72-SYK-CD79B-LYN-CD79A-BLNK)
→
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK)
(modification, collaborate)
Fusaki et al., Eur J Immunol 2000
-
NCI Pathway Database BCR signaling pathway:
CD72 (CD72)
→
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK)
(modification, collaborate)
Fusaki et al., Eur J Immunol 2000
-
NCI Pathway Database BCR signaling pathway:
RasGAP (RASA1)
→
B-cell antigen/BCR complex/FcgammaRIIB complex (FCGR2B-CD79B-CD79A)
(modification, collaborate)
Tamir et al., Immunity 2000
-
NCI Pathway Database BCR signaling pathway:
p62DOK (DOK1)
→
B-cell antigen/BCR complex/FcgammaRIIB complex (FCGR2B-CD79B-CD79A)
(modification, collaborate)
Tamir et al., Immunity 2000
-
NCI Pathway Database BCR signaling pathway:
SHIP (INPP5D)
→
B-cell antigen/BCR complex/FcgammaRIIB complex (FCGR2B-CD79B-CD79A)
(modification, collaborate)
Tamir et al., Immunity 2000
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/LYN complex (LYN-CD79B-CD79A)
→
Bam32 (DAPP1)
(modification, activates)
Marshall et al., J Exp Med 2000, Anderson et al., Curr Biol 2000
Evidence: assay, physical interaction
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/LYN complex (LYN-CD79B-CD79A)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, activates)
Marshall et al., J Exp Med 2000, Anderson et al., Curr Biol 2000
Evidence: assay, physical interaction
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/LYN complex (LYN-CD79B-CD79A)
→
CD22 (CD22)
(modification, activates)
Schulte et al., Science 1992*
Evidence: assay, physical interaction
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex complex (CD79B-CD79A)
→
LYN (LYN)
(modification, collaborate)
Katagiri et al., J Biol Chem 1995
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex complex (CD79B-CD79A)
→
PAG1/CSK complex (PAG1-CSK)
(modification, collaborate)
Katagiri et al., J Biol Chem 1995
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex complex (CD79B-CD79A)
→
B-cell antigen/BCR complex/LYN complex (LYN-CD79B-CD79A)
(modification, collaborate)
Katagiri et al., J Biol Chem 1995
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex complex (CD79B-CD79A)
→
CD45 (PTPRC)
(modification, collaborate)
Katagiri et al., J Biol Chem 1995
-
NCI Pathway Database BCR signaling pathway:
LYN (LYN)
→
B-cell antigen/BCR complex/LYN complex (LYN-CD79B-CD79A)
(modification, collaborate)
Katagiri et al., J Biol Chem 1995
-
NCI Pathway Database BCR signaling pathway:
PAG1/CSK complex (PAG1-CSK)
→
B-cell antigen/BCR complex/LYN complex (LYN-CD79B-CD79A)
(modification, inhibits)
Katagiri et al., J Biol Chem 1995
-
NCI Pathway Database BCR signaling pathway:
CD19 (CD19)
→
B-cell antigen/BCR complex/LYN/SYK/BLNK complex (LYN-SYK-BLNK-CD79B-CD79A)
(modification, activates)
O'Rourke et al., Immunity 1998
Evidence: assay, physical interaction
-
NCI Pathway Database BCR signaling pathway:
SHIP (INPP5D)
→
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK)
(modification, inhibits)
-
NCI Pathway Database BCR signaling pathway:
None
→
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK)
(modification, collaborate)
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK)
(modification, activates)
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK)
→
None
(modification, activates)
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex complex (CD79B-CD79A)
→
FcgammaRIIB (FCGR2B)
(modification, collaborate)
Vuica et al., J Exp Med 1997*
Evidence: assay, other species
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex complex (CD79B-CD79A)
→
B-cell antigen/BCR complex/FcgammaRIIB complex (FCGR2B-CD79B-CD79A)
(modification, collaborate)
Vuica et al., J Exp Med 1997*
Evidence: assay, other species
-
NCI Pathway Database BCR signaling pathway:
FcgammaRIIB (FCGR2B)
→
B-cell antigen/BCR complex/FcgammaRIIB complex (FCGR2B-CD79B-CD79A)
(modification, collaborate)
Vuica et al., J Exp Med 1997*
Evidence: assay, other species
-
Reactome Reaction:
CD79A
→
CD79B
(reaction)
Baldock et al., Protein Expr Purif 2000, Watanabe et al., Biochem Biophys Res Commun 2000, Engels et al., Eur J Immunol 2001, Kabak et al., Mol Cell Biol 2002, Chiu et al., EMBO J 2002, Irish et al., J Immunol 2006, Chen et al., Blood 2008, Papp et al., Biochemistry 2007, Tsang et al., J Biol Chem 2008, Oellerich et al., Mol Cell Proteomics 2009, Bohnenberger et al., Eur J Immunol 2011, Oellerich et al., EMBO J 2011, Rowley et al., J Biol Chem 1995, Law et al., J Biol Chem 1994, Fu et al., J Biol Chem 1997, Fu et al., Immunity 1998, Wienands et al., J Exp Med 1998
-
Reactome Reaction:
CD79A
→
CD79B
(direct_complex)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
CD79A
—
CD79B
(direct interaction, pull down)
Pao et al., J Immunol 1998*
-
IRef Biogrid Interaction:
CD79A
—
CD79B
(physical association, affinity chromatography technology)
Schamel et al., Proc Natl Acad Sci U S A 2003*
-
Gene Ontology Complexes B cell receptor complex:
B cell receptor complex complex (SYK-CD79B-CD79A)
-
IRef Hprd Interaction:
CD79B
—
CD79A
(in vivo)
Reth et al., Annu Rev Immunol 1992*, Astsaturov et al., Leukemia 1996*
-
IRef Hprd Interaction:
Complex of CD79A-PTPRC-CD79B-CD79B-CD79A-PTPRC-CD79A-PTPRC-CD79B
(in vivo)
Brown et al., J Biol Chem 1994*
-
IRef Ophid Interaction:
CD79A
—
CD79B
(aggregation, confirmational text mining)
Astsaturov et al., Leukemia 1996*
-
IRef Ophid Interaction:
CD79A
—
CD79B
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Sei et al., J Biol Chem 1999
(Calcium Signaling) :
Furthermore,
BCR mediated
Ca2+ release in CD19 ( + ) B cells was significantly altered by 4-chloro-m-cresol and ryanodine ... These results indicate that RYR1 functions as a Ca2+ release channel during
BCR stimulated
Ca2+ signaling and suggest that complex Ca2+ signals that control the cellular activities of B cells may be generated by cooperation of the IP3 receptor and RYR1
Wagle et al., J Immunol 1999
:
Here we investigate the influence of the FcgammaRIIB1 on BCR mediated Ag processing and show that coligating the FcgammaRIIB1 and the
BCR negatively
regulates both
BCR signaling for enhanced Ag processing and BCR mediated Ag internalization
Hitomi et al., FEBS Lett 1999
:
Herein we provide biochemical and genetic evidence that cross linking of the
B cell receptor (BCR) induces rapid activation of
PLD through a Syk-, Btk- and phospholipase C (PLC)-gamma2 dependent pathway in DT40 cells ... These results demonstrate that Syk, Btk and PLC-gamma2 are essential for
BCR induced
PLD activation
Buhl et al., J Immunol 1999
(Calcium Signaling...) :
Bruton's tyrosine kinase (Btk) plays a critical role in
B cell Ag receptor (BCR) signaling, as indicated by the X-linked immunodeficiency and X-linked agammaglobulinemia phenotypes of mice and men that express mutant forms of the kinase
Krzysiek et al., J Immunol 1999
:
We show herein that
B cell Ag receptor (BCR) triggering, but not
stimulation by CD40 mAb and/or
IL-4 , rapidly induced the coordinated expression of two closely related T cell chemoattractants, macrophage inflammatory protein-1 beta ( MIP-1 beta ) and MIP-1 alpha, by human B cells
Harmer et al., J Biol Chem 1999
:
Here, we report that cross linking of the
BCR induces association between Grb2 and SHIP as well as association between
Shc and SHIP ... Here, we report that cross linking of the
BCR induces association between
Grb2 and SHIP as well as association between Shc and SHIP
Nieborowska-Skorska et al., J Exp Med 1999
(Leukemia) :
Together, these data demonstrate that
STAT5 activation by
BCR/ABL is dependent on signaling from more than one domain and document the important role of STAT5 regulated pathways in BCR/ABL leukemogenesis
Maeda et al., Oncogene 1999
(Calcium Signaling) :
Paired immunoglobulin-like receptor B ( PIR-B ) inhibits
BCR induced activation of Syk and
Btk by SHP-1 ... Paired immunoglobulin-like receptor B ( PIR-B ) inhibits
BCR induced
activation of
Syk and Btk by SHP-1
Li et al., Proc Natl Acad Sci U S A 1999
:
In this study, we demonstrate that ligation of
B cell antigen receptor (BCR) leads to activation of
Akt/PKB in B lymphocytes ... In this study, we demonstrate that ligation of
B cell antigen receptor (BCR) leads to activation of
Akt/PKB in B lymphocytes ...
BCR induced activation of Akt/PKB
required the tyrosine kinase
Syk , which was not previously known to regulate Akt/PKB ...
BCR induced
activation of
Akt/PKB required the tyrosine kinase Syk, which was not previously known to regulate Akt/PKB ...
BCR induced
activation of
Akt/PKB required the tyrosine kinase Syk, which was not previously known to regulate Akt/PKB ... Our results show that Lyn provides a mechanism for negative regulation and opposes the effect of Syk on
BCR mediated activation of
Akt/PKB ... Our results show that Lyn provides a mechanism for negative regulation and opposes the effect of Syk on
BCR mediated activation of
Akt/PKB
Astoul et al., J Cell Biol 1999
:
Membrane translocation of PKB and subsequent PKB activation are dependent on
BCR activation of
phosphatidylinositol 3-kinase (PI3K) ...
Membrane translocation of PKB and subsequent PKB activation are
dependent on
BCR activation of phosphatidylinositol 3-kinase (PI3K) ... Membrane translocation of PKB and subsequent
PKB activation are
dependent on
BCR activation of phosphatidylinositol 3-kinase (PI3K)
Gold et al., J Immunol 1999
:
We have previously shown that the
B cell Ag receptor (BCR) activates
phosphatidylinositol (PI) 3-kinase
Tanguay et al., J Immunol 1999
:
These results suggest that assembly or stabilization of D-type cyclin holoenzyme complexes 1 ) is an important step in the
activation of
Cdk4/6 by
BCR signals, and 2 ) suffice in providing a mechanism to account for inhibition of BCR stimulated Rb protein phosphorylation by Fc gamma R ... These results suggest that assembly or stabilization of D-type cyclin holoenzyme complexes 1 ) is an important step in the
activation of
Cdk4/6 by
BCR signals, and 2 ) suffice in providing a mechanism to account for inhibition of BCR stimulated Rb protein phosphorylation by Fc gamma R
Gross et al., Mol Cell Biol 1999
(Cell Transformation, Neoplastic...) :
We have recently shown that expression of Bcr-Abl in bone marrow cells by retroviral transduction efficiently induces in mice a myeloproliferative disease resembling human CML and that
Abl kinase activity is
essential for
Bcr-Abl to induce a CML-like myeloproliferative disease
Craxton et al., J Biol Chem 1999
:
Increased
BCR induced
Akt phosphorylation was observed in Lyn-deficient DT40 cells and Lyn ( -/- ) mice compared with wild-type cells suggesting that Lyn may negatively regulate Akt function
Su et al., J Biol Chem 1999
:
Finally, we show that co-ligation of CD19 with the BCR results in increased tyrosine phosphorylation of STAT1 relative to BCR cross linking alone, establishing CD19 as a positive modulator of
BCR mediated
STAT activation
Yankee et al., J Immunol 1999
:
These studies indicate that
c-Cbl may
contribute to the regulation of
BCR signaling by modulating the ability of Syk to associate with the BCR and couple the receptor to intracellular signaling pathways
Ingham et al., J Immunol 1999
:
Tyrosine phosphorylation of
Shc in
response to
B cell Ag receptor (BCR) engagement creates binding sites for the Src homology 2 (SH2) domain of Grb2 ...
BCR induced tyrosine phosphorylation of
Shc could be restored in the these cells by expressing wild-type SHIP but not by expressing a mutant form of SHIP that can not bind to Shc
Adachi et al., J Immunol 2000
(Calcium Signaling...) :
In this paper we demonstrate that expression of CD72 down-modulates both extracellular signal related kinase ( ERK ) activation and Ca2+ mobilization induced by BCR ligation in the mouse B lymphoma line K46micromlambda, whereas
BCR mediated
ERK activation was not reduced by the ITIM mutated form of CD72
Wei et al., J Immunol 2000
:
Consequently, up-regulation of TdT and
IL-7R alpha expression requires signaling through the high affinity IL-7R, but does not
require cmu expression or a functional
pre-BCR
Rhodes et al., Exp Hematol 2000
:
Additionally, in the
presence of
Bcr-Abl ,
CrkL is found in the nucleus, can be detected in a Stat5/DNA complex, and increases transcriptional activation from a Stat-responsive reporter construct
Horita et al., J Exp Med 2000
(Blast Crisis...) :
Here, we show that the interleukin 3-independent expression of the antiapoptotic protein,
Bcl-xL , is
induced by
Bcr-Abl through activation of signal transducer and activator of transcription ( Stat ) 5 ... Here, we show that the
interleukin 3-independent expression of the antiapoptotic protein, Bcl-xL, is
induced by
Bcr-Abl through activation of signal transducer and activator of transcription ( Stat ) 5
Tamir et al., Immunity 2000
:
This function is reportedly mediated in part by inhibition of
B cell antigen receptor (BCR) mediated
p21ras activation, though the basis of this inhibition is unknown
Voss et al., Oncogene 2000
(MAP Kinase Signaling System...) :
The mitogenic MAPK/Erk kinases as well as
Akt/PKB , a kinase implicated to negatively regulate apoptosis, were also constitutively
activated by both
Bcr-Abl and Tel-Abl ... The mitogenic MAPK/Erk kinases as well as
Akt/PKB , a kinase implicated to negatively regulate apoptosis, were also constitutively
activated by both
Bcr-Abl and Tel-Abl
Dunant et al., Cell Signal 2000
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
Expression of
Bcr-Abl induced tyrosine phosphorylation of both
Dok1 and SHIP1 and the formation of a Dok1/SHIP1 complex ... Expression of
Bcr-Abl induced tyrosine phosphorylation of both Dok1 and
SHIP1 and the formation of a Dok1/SHIP1 complex
Lionberger et al., J Biol Chem 2000
(Leukemia, Myeloid) :
Recent work shows that
Hck , a member of the Src tyrosine kinase family with myeloid restricted expression, associates with and is
activated by
Bcr-Abl
Puccetti et al., Cancer Res 2000
(Blast Crisis...) :
Here, we report that : ( a ) As2O3 induced apoptosis in Ph+ but not in Ph- lymphoblasts ; ( b ) enforced expression of
BCR-ABL in U937 cells dramatically increased the sensitivity to As2O3 ; ( c ) the effect of As2O3 was
independent of
BCR-ABL kinase activity ; and ( d ) As2O3 reduced proliferation of chronic myelogenous leukemia blasts but not of peripheral CD34+ progenitors
Perrotti et al., Mol Cell Biol 2000
:
The DNA binding activity of
FUS ( also known as TLS ), a nuclear pro-oncogene involved in multiple translocations, is
regulated by
BCR-ABL in a protein kinase CbetaII ( PKCbetaII ) -dependent manner ... FUS proteolysis is induced by
c-Jun , is
suppressed by
BCR-ABL or Jun kinase 1, and does not depend on c-Jun transactivation potential, ubiquitination, or its interaction with Jun kinase 1 ...
FUS proteolysis is induced by c-Jun, is
suppressed by
BCR-ABL or Jun kinase 1, and does not depend on c-Jun transactivation potential, ubiquitination, or its interaction with Jun kinase 1
Gesbert et al., J Biol Chem 2000
:
We demonstrate that the decrease of
p27 ( Kip1 ) is directly
due to
BCR/ABL in hematopoietic cells by two different approaches ... The PI3K inhibitor LY-294002 blocks the ability of
BCR/ABL to
induce p27 ( Kip1 ) down-regulation and inhibits BCR/ABL induced entry into S phase ... Overall, these data are consistent with a model in which
BCR/ABL suppresses
p27 ( Kip1 ) protein levels through PI3K/AKT, leading to accelerated entry into S phase
Swart et al., Biochem Biophys Res Commun 2000
:
We have recently demonstrated that
BCR cross linking
leads to a transient activation of
p38 mitogen activated protein kinase ( MAPK ) in CH31 B cells
Otero et al., J Biol Chem 2001
(Lymphoma, B-Cell) :
A prominent feature of CD19 signaling is the binding and activation of phosphoinositide 3-kinase ( P13K ), which accounts for the majority of
PI3K activity
induced by
BCR ligation
Petro et al., J Biol Chem 2001
:
Specifically, pharmacologic agents that block the action of either PLC-gamma2 or its second messengers prevent
BCR induced activation of
IkappaB kinase ... Moreover, activation of
NF-kappaB in
response to
BCR signaling is completely abolished in B cells deficient for PLC-gamma2
Gold et al., Immunol Rev 2000
:
In this review, we discuss the
role of phosphatidylinositol 3-kinase (PI3K) and
Rap 1 in
B-cell receptor (BCR) signaling ... In this review, we discuss the
role of
phosphatidylinositol 3-kinase (PI3K) and Rap 1 in
B-cell receptor (BCR) signaling ... We showed that the
BCR activates
Rap1 via phospholipase C-dependent production of diacylglycerol
Doody et al., EMBO J 2000
:
The CD19 co-receptor physically interacts with Vav-2 and synergistically enhances
Vav-2 phosphorylation
induced by the
B-cell receptor (BCR)
Dykstra et al., Immunity 2001
:
Here, we show that
LMP2A resides in lipid rafts and excludes the BCR from entering rafts by Lyndependent mechanisms, thus
blocking both
BCR signaling and antigen transport
Ogimoto et al., FEBS Lett 2001
(MAP Kinase Signaling System) :
We found that CD45 negatively regulated
BCR induced c-Jun NH ( 2 ) -terminal kinase ( JNK ) and
p38 activation in immature WEHI-231 cells, whereas in mature BAL-17 cells, CD45 positively regulated JNK and p38 activation and negatively regulated extracellular signal regulated kinase activity
Baba et al., Proc Natl Acad Sci U S A 2001
:
The existence of such an activation mechanism is supported by the observation that the
BCR induced
Btk phosphorylation and activation are significantly reduced in BLNK-deficient B cells as well as in Syk-deficient B cells
Cheng et al., J Immunol 2001
:
Translocation of the
BCR into lipid rafts did not
require the
Ig alpha/Ig beta signaling complex, was not dependent on engagement of the FcR, and was not blocked by the Src family kinase inhibitor PP2 or the actin depolymerizing agents cytochalasin D or latrunculin ... Translocation of the
BCR into lipid rafts did not
require the Ig
alpha/Ig beta signaling complex, was not dependent on engagement of the FcR, and was not blocked by the Src family kinase inhibitor PP2 or the actin depolymerizing agents cytochalasin D or latrunculin
Richards et al., J Immunol 2001
(MAP Kinase Signaling System) :
PD98059 or U0126 treatment substantially inhibited the
BCR induced activation of the extracellular signal regulated kinase (
ERK ) forms of mitogen activated protein kinase in the immature B cell line WEHI-231, in immature splenic B cells, and in mature splenic B cells
Ingham et al., J Biol Chem 2001
:
Gab1 expression also increased
BCR induced tyrosine phosphorylation of SHP2 as well as the binding of
Grb2 to SHP2 ... Gab1 expression also increased
BCR induced tyrosine phosphorylation of SHP2 as well as the binding of Grb2 to
SHP2 ... We show that the pleckstrin homology (PH) domain of Gab1 is required for
BCR induced phosphorylation of Gab1 and for Gab1 participation in
BCR signaling ... We show that the pleckstrin homology (PH) domain of Gab1 is required for
BCR induced phosphorylation of
Gab1 and for Gab1 participation in BCR signaling ... Moreover, using confocal microscopy, we show that
BCR ligation can
induce the translocation of
Gab1 from the cytosol to the plasma membrane and that this requires the Gab1 PH domain as well as PI3K activity ... Moreover, using confocal microscopy, we show that
BCR ligation can induce the translocation of Gab1 from the cytosol to the plasma membrane and that this
requires the Gab1 PH domain as well as
PI3K activity
Nitta et al., Exp Cell Res 2001
:
Furthermore, addition of spermine could repress the BCR mediated apoptosis by attenuating the mitochondrial membrane potential ( Deltapsim ) loss and
activation of
caspase-7 induced by
BCR signaling
Tian et al., Int Immunol 2001
:
For BCR induced apoptosis, we provide evidence that the final apoptotic destruction phase can be inhibited by the pan-caspase inhibitor
BOC-Asp-FMK ( BD ) and that, in the presence of BD, the
BCR only
induces growth arrest which is reversible ... For BCR induced apoptosis, we provide evidence that the final apoptotic destruction phase can be inhibited by the pan-caspase inhibitor
BOC-Asp-FMK ( BD ) and that, in the presence of BD, the
BCR only
induces growth arrest which is reversible
Lin et al., Oncogene 2001
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
Induction of exogenous
Bcr protein by removal of
Tet from the culture medium caused a dramatic increase in Bcr serine kinase activity, yielding predominantly phosphoserine Bcr, despite the presence of Bcr-Abl in the kinase reaction mixture
Fukada et al., J Biol Chem 2001
:
Previously, we have shown that the expression of
PTP1B is
enhanced by p210
Bcr-Abl and that PTP1B is a specific antagonist of transformation induced by this oncoprotein protein-tyrosine kinase ... The binding of
Egr-1 to PRS is
suppressed by p210
Bcr-Abl due to the inhibition of Egr-1 expression, resulting in the enhancement of PTP1B promoter activity ... The binding of Egr-1 to
PRS is
suppressed by p210
Bcr-Abl due to the inhibition of Egr-1 expression, resulting in the enhancement of PTP1B promoter activity
Bone et al., Int Immunol 2001
:
Nuclear NF-kappaB is induced in B cells by engagement of either the
BCR or CD40 or by
stimulation with
lipopolysaccharide (LPS) ... Nuclear
NF-kappaB is
induced in B cells by engagement of either the
BCR or CD40 or by stimulation with lipopolysaccharide (LPS) ... Interestingly, a PKC inhibitor which blocked the
BCR induced
IkappaBalpha degradation had no effect on the degradation of IkappaBalpha after LPS stimulation
Natarajan et al., J Immunol 2001
(Second Messenger Systems) :
Whereas
B cell Ag receptor (BCR) cross linking alone
stimulated increased expression of
CD86 , up-regulation of CD80 required dual stimulation with anti-IgM and anti-CD54
Wu et al., J Immunol 2001
(Severe Combined Immunodeficiency) :
Although both CD72 and
BCR induced
Btk dependent ERK activation, CD72 mediated proliferation is more resistant to blocking of ERK activity than that of BCR, as shown by the proliferation response of B cells treated with PD98059 and dibutyryl cAMP, agents that inhibit ERK activity ... Although both CD72 and
BCR induced Btk dependent
ERK activation, CD72 mediated proliferation is more resistant to blocking of ERK activity than that of BCR, as shown by the proliferation response of B cells treated with PD98059 and dibutyryl cAMP, agents that inhibit ERK activity
Watanabe et al., J Biol Chem 2001
:
Substitution of all four tyrosine residues almost completely eliminated the
BCR induced
PLCgamma2 phosphorylation, indicating that these residues include the major phosphorylation sites upon BCR engagement
Che et al., Circulation 2001
:
Overexpression of
Bcr also enhanced PDGF induced Ras/Raf-1 activity and DNA synthesis, but this regulation is
independent of the kinase activity of
Bcr
Benschop et al., J Immunol 2001
:
BCR induced tyrosine phosphorylation of CD79a, Lyn,
B cell linker protein , and phospholipase Cgamma2 is enhanced in immature B cells and they exhibit greater capacitative calcium entry in response to Ag ...
BCR induced tyrosine phosphorylation of
CD79a , Lyn, B cell linker protein, and phospholipase Cgamma2 is enhanced in immature B cells and they exhibit greater capacitative calcium entry in response to Ag ...
BCR induced tyrosine phosphorylation of CD79a,
Lyn , B cell linker protein, and phospholipase Cgamma2 is enhanced in immature B cells and they exhibit greater capacitative calcium entry in response to Ag ...
BCR induced tyrosine phosphorylation of CD79a, Lyn, B cell linker protein, and
phospholipase Cgamma2 is enhanced in immature B cells and they exhibit greater capacitative calcium entry in response to Ag
Okazaki et al., Proc Natl Acad Sci U S A 2001
:
These results show that
PD-1 can
inhibit BCR signaling by recruiting SHP-2 to its phosphotyrosine and dephosphorylating key signal transducers of BCR signaling ... These results show that PD-1 can
inhibit BCR signaling by recruiting
SHP-2 to its phosphotyrosine and dephosphorylating key signal transducers of BCR signaling
Banerji et al., Oncogene 2001
(Lymphoma, B-Cell...) :
We show that
BCR stimulation of WEHI 231 cells
results in down-regulation of
cyclin D2 and up-regulation of p27 ( Kip1 ), which are associated with pocket protein hypophosphorylation and E2F inactivation ... We show that
BCR stimulation of WEHI 231 cells
results in down-regulation of cyclin D2 and up-regulation of
p27 ( Kip1 ), which are associated with pocket protein hypophosphorylation and E2F inactivation
Yokohari et al., Biochem Biophys Res Commun 2001
:
Here we show that overexpression of BRDG1 strongly augments
BCR mediated activation of cAMP-response element binding protein (
CREB ) but not that of c-Jun and the promoters of c-MYC and BCL-xL genes
Perrotti et al., Nat Genet 2002
(Blast Crisis...) :
BCR-ABL suppresses
C/EBPalpha expression through inhibitory action of hnRNP E2
Niiro et al., J Exp Med 2002
(Calcium Signaling) :
Moreover,
BCR induced
activation of extracellular signal regulated kinase ( ERK ), c-jun NH2-terminal kinase ( JNK ), and
p38 mitogen activated protein kinase ( MAPK ) pathways was impaired in Bam32 ( -/- ) cells but not the activation of Akt related pathways ... Moreover,
BCR induced
activation of extracellular signal regulated kinase (
ERK ), c-jun NH2-terminal kinase ( JNK ), and p38 mitogen activated protein kinase ( MAPK ) pathways was impaired in Bam32 ( -/- ) cells but not the activation of Akt related pathways
Bassermann et al., J Biol Chem 2002
:
The oncogenic tyrosine kinase
Bcr-Abl has been shown to
activate Rac-1 , which is important for Bcr-Abl induced leukemogenesis ...
Activation of
Rac-1 by
Bcr-Abl was abrogated by co-expression of the Vav C terminus encoding the SH3-SH2-SH3 domains as a dominant negative construct
Abe et al., Ann N Y Acad Sci 2001
:
A dominant negative Ras did not inhibit Bcr kinase activation, and overexpression of
Bcr increased
Ras/Raf-1 activity and DNA synthesis
Piatelli et al., J Biol Chem 2002
:
Disruption of endogenous heat shock protein 90 (hsp90) function with geldanamycin abrogated
BCR induced
cyclin D2 expression and proliferation
Spiekermann et al., Exp Hematol 2002
(Cell Transformation, Neoplastic...) :
Stable transfection of BA/F3 cells with TEL-JAK2, TEL-ABL, and BCR-ABL resulted in IL-3 independent growth and strong
activation of
STAT3 and STAT5 by TEL-JAK2 and TEL-ABL, but not by
BCR-ABL ... Stable transfection of BA/F3 cells with TEL-JAK2, TEL-ABL, and BCR-ABL resulted in IL-3 independent growth and strong
activation of STAT3 and
STAT5 by TEL-JAK2 and TEL-ABL, but not by
BCR-ABL
Kövesdi et al., Cell Signal 2002
(Calcium Signaling) :
Both
BLNK and phospholipase C ( PLC ) gamma were raft associated in unstimulated pre-B cells, and this could not be
enhanced by
pre-BCR engagement, suggesting a ligand independent PLC gamma mediated signaling
Tsubata et al., Int Rev Immunol 2001
:
BCR proximal signaling occurs within cholesterol- and sphingolipid-rich plasma membrane microdomains termed lipid rafts, and
involves tyrosine kinases such as Lyn, Syk and Btk and the adapter molecule
SLP65/BLNK
Pierce et al., Hematol J 2001
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
This enhanced
BCR/ABL mediated growth inhibition occurred over a range of growth factor concentrations and was
independent of changes in
p21 ( Cip1 ) and p27 ( Kip ) levels ... This enhanced
BCR/ABL mediated growth inhibition occurred over a range of growth factor concentrations and was
independent of changes in p21 ( Cip1 ) and
p27 ( Kip ) levels
Inabe et al., FEBS Lett 2002
(Agammaglobulinemia) :
Recent studies have shown that Btk plays an important role in
BCR mediated
c-Jun NH ( 2 ) -terminal kinase ( JNK ) 1
activation ; however, the mechanism by which Btk participates in the JNK1 response remains elusive
Jacob et al., J Biol Chem 2002
:
Here we demonstrate through the use of PI 3-kinase inhibitors and a dominant negative PI 3-kinase construct that the
BCR induced phosphorylation and activation of
ERK is dependent on PI 3-kinase
Lajaunias et al., J Immunol 2002
(Calcium Signaling) :
Moreover, in CD22-deficient mice, anti-IgM treatment did not trigger enhanced Ca ( 2+ ) influx in CD5 ( + ) B-1 cells, unlike CD22-deficient splenic B-2 cells, suggesting a relatively limited
role of
CD22 in
BCR signaling in B-1 cells
Kawauchi et al., Int J Hematol 2002
(Leukemia, Lymphocytic, Chronic, B-Cell...) :
In B-CLL cells,
BCR cross linking neither induced activation nor
enhanced the activities of Lyn, Syk, p21ras, JNK, p38
MAPK , or Akt kinases, whereas p38 MAPK and Akt were constitutively active ... In B-CLL cells,
BCR cross linking neither induced activation nor
enhanced the activities of
Lyn , Syk, p21ras, JNK, p38 MAPK, or Akt kinases, whereas p38 MAPK and Akt were constitutively active
Korus et al., Oncogene 2002
(MAP Kinase Signaling System) :
NF-kappaB activation by
Bcr is not mediated by nuclear translocation, but rather by p38 mitogen activated protein kinase ( MAPK ) -dependent modification of the RelA/p65 transactivation domain
Era et al., Int J Hematol 2002
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
Although a great amount of knowledge has been accumulated, the
effect of
Bcr-Abl on the
HSC is still unclear
Keeshan et al., Leukemia 2002
:
High
Bcr-Abl expression
prevents the translocation of
Bax and Bad to the mitochondrion
Sen et al., Mol Immunol 2002
:
In both B-1 and B-2 cells
BCR cross linking
induced a modest increase of CD19 associated
Lyn , a Src family protein tyrosine kinase ( PTK ) thought to be important for CD19 phosphorylation
Xie et al., Oncogene 2002
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
Jak2 is involved in
c-Myc induction by
Bcr-Abl ... In summary, our findings indicate that Jak2 mediates the increase in
c-Myc expression that is
induced by
Bcr-Abl
Mongini et al., Cell Immunol 2002
:
In the absence of IL-4,
BCR : CD21 co-ligation augmented BCR triggered CD86 only under conditions of very low BCR ligand dose or affinity, and
CD80 was minimally
induced by BCR and/or CD21 crosslinking
Grill et al., Blood 2002
(MAP Kinase Signaling System) :
Rac-1 was also
activated by colony stimulating factor-1 (CSF-1), Steel locus factor ( SLF ), granulocyte-macrophage colony stimulating factor ( GM-CSF ), and IL-5 or by cross linking the
B-lymphocyte receptor for antigen (BCR)
Jiang et al., Blood 2002
(Cell Transformation, Neoplastic...) :
These findings provide new evidence that
IL-3 production is a rapid, sustained, and biologically relevant
consequence of
BCR-ABL expression in primitive hematopoietic cells with multilineage leukemogenic activity
Chen et al., Blood 2002
(Diseases in Twins...) :
Following BCR ligation, ZAP-70 underwent tyrosine phosphorylation and became associated with surface immunoglobulin and CD79b, arguing for the
involvement of
ZAP-70 in
BCR signaling
Mayerhofer et al., Blood 2002
:
BCR/ABL induces expression of
vascular endothelial growth factor and its transcriptional activator, hypoxia inducible factor-1alpha, through a pathway involving phosphoinositide 3-kinase and the mammalian target of rapamycin ... We show here that the CML associated oncogene
BCR/ABL induces
VEGF gene expression in growth factor dependent Ba/F3 cells ...
BCR/ABL induced
VEGF gene expression was counteracted by the phosphoinositide 3-kinase ( PI3-kinase ) inhibitor LY294002 and rapamycin, an antagonist of mammalian target of rapamycin (mTOR), but not by inhibition of the mitogen activated protein kinase pathway ... Similarly,
BCR/ABL dependent
HIF-1alpha expression was inhibited by the addition of LY294002 and rapamycin
Schuster et al., Blood 2003
:
In contrast, the up-regulation of PU.1 and
p27 ( Kip1 ) by G-CSF was not
affected by
Bcr-Abl ... Importantly, incubation of 32D ( Bcr-Ablwt ) cells with the kinase inhibitor imatinib mesylate prior to G-CSF stimulation completely neutralized the
effects of
Bcr-Abl on granulocytic differentiation and on
C/EBPalpha and C/EBPepsilon expression ... Importantly, incubation of 32D ( Bcr-Ablwt ) cells with the kinase inhibitor imatinib mesylate prior to G-CSF stimulation completely neutralized the
effects of
Bcr-Abl on granulocytic differentiation and on C/EBPalpha and
C/EBPepsilon expression
Wilson et al., Oncogene 2002
(Cell Transformation, Neoplastic...) :
These data implicate the Src kinase family in Stat5 and
Erk activation downstream of
Bcr-Abl , and identify myeloid-specific Src kinases as potential drug targets in CML
Ebos et al., Mol Cancer Res 2002
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive...) :
Imatinib mesylate ( STI-571 ) reduces
Bcr-Abl mediated
vascular endothelial growth factor secretion in chronic myelogenous leukemia ... Transfection of
BCR-ABL into murine myeloid 32D and human megakaryocyte MO7e hematopoietic cells
resulted in enhanced
VEGF expression, which could be further elevated by the exposure to cytokines such as interleukin 3 and granulocyte macrophage colony stimulating factor
Frissora et al., Eur J Immunol 2003
:
Stimulation through
BCR resulted in dose dependent induction of
CREB-1 binding to the consensus cyclic AMP-responsive element ... Recombinant IFN-gamma inhibited the
BCR induced
CREB-1 DNA binding activity and cell proliferation in B cells from signal transducer and activator of transcription-1 ( STAT-1 ) ( +/+ ), but not STAT-1 ( -/- ) mice
Glassford et al., Oncogene 2003
(Calcium Signaling...) :
Collectively, these data provide evidence for the concept that the B-cell signalosome ( p85alpha, Btk, BLNK and PLCgamma ) is involved in regulating
cyclin D2 expression in
response to
BCR engagement
Marshall-Clarke et al., Immunology 2003
:
We show that activity of the enzyme phosphatidylinositol 3-kinase is critical for MHC II hyperexpression and induction of
CD86 in
response to ligation of the
BCR or CD38, but not for responses to other stimuli including interleukin-4, lipopolysaccharide and CD40 ligation
Johmura et al., Immunity 2003
:
We demonstrate here that adaptor molecules Grb2 and BLNK, in addition to Vav, are required for efficient
Rac1 activation in
response to
BCR stimulation
Hanson et al., J Biol Chem 2003
:
Consistent with this, evidence has been presented that
NF kappa B activity is
required for Ras and
BCR-ABL to transform cells ... The data presented here indicate that
BCR-ABL expression in 32D myeloid cells or oncogenic Ras expression in murine fibroblasts
blocks the ability of tumor necrosis factor (TNF) to activate
NF kappa B
Yu et al., Blood 2003
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
These events were accompanied by down-regulation of the
Raf-1/mitogen induced extracellular kinase ( MEK ) /extracellular signal related kinase ( ERK ) pathway as well as diminished expression of
Bcr/Abl and cyclin D1, cleavage of p21CIP1 and phosphorylation of the retinoblastoma protein ( pRb ), and induction of the stress related kinases Jun kinase (JNK) and p38 mitogen activated protein kinase ( MAPK )
Christian et al., J Biol Chem 2003
:
Preventing Rap activation also increased the ability of the
BCR to
stimulate Akt dependent phosphorylation of the FKHR
transcription factor on negative regulatory sites and decreased the levels of p27Kip1, a pro-apoptotic factor whose transcription is enhanced by FKHR ... Thus
activation of endogenous
Rap by the
BCR limits BCR induced activation of the PI3K/Akt pathway, opposes the subsequent inhibition of the FKHR/p27Kip1 pro-apoptotic module, and enhances BCR induced cell death ... Consistent with the idea that Rap-GTP is a negative regulator of the PI3K/Akt pathway, expressing constitutively active Rap2 ( Rap2V12 ) reduced
BCR induced phosphorylation of Akt and
FKHR ... Consistent with the idea that Rap-GTP is a negative regulator of the PI3K/Akt pathway, expressing constitutively active Rap2 ( Rap2V12 ) reduced
BCR induced phosphorylation of
Akt and FKHR
Hao et al., EMBO J 2003
:
We show here that like NFAT,
BCR regulation of
SRF occurs via an Src-Syk-Tec-PLCgamma-Ca ( 2+ ) ( Lyn-Syk-Btk-PLCgamma-Ca ( 2+ ) ) pathway
Wen et al., J Biol Chem 2003
:
PLCgamma2 plays a critical role in
B cell receptor (BCR) signaling and its targeted deletion results in defective B cell development and function
Masilamani et al., Eur J Immunol 2003
:
CD21 shedding is induced by stimulation with PMA plus Ca ( 2+ ) ionophore, or by
stimulation of the
BCR with
anti-IgM+anti-CD40
Barel et al., Eur J Immunol 2003
(Epstein-Barr Virus Infections) :
The specificity of CR2 pathway was clearly demonstrated as neither CD19 nor
BCR could
induce tyrosine phosphorylation of
nucleolin in normal B lymphocytes
Keeshan et al., Br J Haematol 2003
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
Bcr-Abl upregulates cytosolic
p21WAF-1/CIP-1 by a phosphoinositide-3-kinase (PI3K) independent pathway
Haxhinasto et al., J Immunol 2003
:
In this study, we show that genetic or pharmacologic inhibition of
BCR mediated
PKD activation in B lymphocytes abrogated the synergy between the CD40 and the BCR, as measured by activation of Ig and cytokine secretion
Su et al., J Exp Med 2003
:
This SL-deficient
pre-BCR ( SL-pre-BCR )
requires Ig-alpha for expression on the cell surface
Gustafson et al., J Biol Chem 2004
(Cell Transformation, Neoplastic) :
Bcr-Abl regulates
protein kinase Ciota (PKCiota) transcription via an Elk1 site in the PKCiota promoter
Kim et al., Br J Haematol 2004
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
Imatinib/apicidin co-treatment for 48 h produced a prominent decrease in
Bcr-Abl protein levels in a
caspase dependent manner ... In summary, these data indicate that apicidin potentiates the imatinib induced apoptosis of Bcr-Abl positive leukaemia cells through the enhanced activation of the mitochondria dependent caspase cascades, accompanied by
caspase dependent downregulation of
Bcr-Abl and XIAP
Cherukuri et al., J Immunol 2004
:
Using B cells from CD81-deficient mice we demonstrate that in the absence of CD81, coligated BCR and
CD19/CD21 complexes fail to partition into lipid rafts and
enhance BCR signaling from rafts ... Using B cells from CD81-deficient mice we demonstrate that in the absence of CD81, coligated BCR and
CD19/CD21 complexes fail to partition into lipid rafts and
enhance BCR signaling from rafts
Gaston et al., Exp Hematol 2004
:
In a yeast three-hybrid assay,
Grb2 mediated an interaction between Cbl and
Bcr-Abl that was dependent on a functional Grb2 binding site ...
Grb2 or another, yet unidentified, protein may
mediate an initial interaction between Cbl and
Bcr-Abl that is independent of Cbl tyrosine phosphorylation
Portis et al., Virology 2004
:
LMP2A inhibits
B-cell receptor (BCR) signaling in vitro and allows for the survival of BCR negative B cells in vivo
Patke et al., Curr Opin Immunol 2004
:
BCR signaling
leads to activation of the
inhibitor of NF-kappa B kinase (IKK) complex via Carma1, Bcl10 and MALT1, whereas BAFF-R engagement promotes processing of NF-kappa B2 protein p100, which is dependent on NF-kappa B-inducing kinase (NIK) and IKK alpha
Viau et al., Immunol Lett 2004
:
To test this hypothesis, we investigated the potential
effects of a
SAg , protein L from Peptostreptococcus magnus, on antigen
B cell receptor (BcR) surface expression in vitro ... These data demonstrate that
SAg mediated down-regulation of the
BcR expression occurs primarily as a result of BcR internalization
Chandramohan et al., J Immunol 2004
:
We demonstrate that pharmacologic inhibitors of PI3K or
BCR engagement lead to decreased inactive cytoplasmic levels and
increased active functional nuclear
FOXO3a
Blois et al., J Biol Chem 2004
:
In addition,
BCR induced
CREB phosphorylation is significantly diminished in nPKCdelta-deficient splenic B cells in comparison with wild type mice ... Taken together, these results suggest a model in which
BCR engagement
leads to the phosphorylation of
CREB via a signaling pathway that requires nPKCdelta and p90 RSK in mature B cells
Kövesdi et al., Cell Signal 2004
(MAP Kinase Signaling System) :
We have detected a short lived
BCR-driven activation of mitogen activated protein kinases ( ERK1/2 and p38 MAPK ) and
Akt/PKB in transitional immature B cells that correlated with the lack of c-Fos expression, reduced phosphorylation of Akt substrates and a susceptibility for apoptosis
Leis et al., Leukemia & lymphoma 2004
(Blast Crisis...) :
CSF levels were substantially below the concentration
required for inhibition of
BCR-ABL and killing of cell lines in vitro
Moon et al., Cell Immunol 2004
(Autoimmune Diseases...) :
Lyn , the src-family protein tyrosine kinase,
plays a crucial role in the regulation of
B cell antigen receptor (BCR)- and IL-5-receptor (IL-5R) mediated signaling
Bandyopadhyay et al., Blood 2004
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive...) :
NaChl did not increase phosphorylation of p38 in Bcr-Abl negative cells including HSC-2 and HSG that are responsive to this compound, indicating that
p38 activation by NaChl is
dependent on
Bcr-Abl kinase inhibition
Ehrhardt et al., Mol Cell Biol 2004
:
In contrast, ligation of the
BCR or TCR
resulted in activation of
H-Ras , N-Ras, and K-Ras 4B, but not M-Ras ... In contrast, ligation of the
BCR or TCR
resulted in activation of H-Ras, N-Ras, and K-Ras 4B, but not
M-Ras ... In contrast, ligation of the
BCR or TCR
resulted in activation of H-Ras,
N-Ras , and K-Ras 4B, but not M-Ras
Tian et al., Chin J Cancer 2004
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
BCR-ABL fusion gene is regarded as the molecular hallmark of chronic myelogenous leukemia ( CML ), and its expression is
controlled by the
BCR gene promoter
Taguchi et al., Immunology 2004
:
When pre-BCR was cross linked with anti-micro heavy-chain antibodies, significant phosphorylation of intracellular molecules, including Syk, Shc, ERK MAP kinase, and AKT, and an activation of Ras were observed without regard to deficiency of BLNK expression, suggesting that BLNK is not required for
pre-BCR mediated activation of MAP kinase and
phosphatidyl-inositol 3 (PI3) kinase signalling
Tybulewicz et al., Eur J Immunol 2004
(Second Messenger Systems) :
Unexpectedly, they show that while the
BCR induced phosphorylation of the PI3K dependent kinase
Akt is reduced in p85alpha-deficient cells, the phosphorylation of two downstream targets of Akt -- FOXO1 and ribosomal protein S6 -- is largely unaffected
Katzman et al., J Virol 2004
:
LMP2A prevents
BCR recruitment to lipid rafts, thereby abrogating BCR function
Lin et al., Semin Immunol 2004
(Lymphoma, B-Cell, Marginal Zone) :
Recent studies demonstrate that CARMA1, a scaffold protein, plays an essential role in mediating TCR- or
BCR induced
NF-kappaB activation by recruiting two adaptor proteins, Bcl10 and MALT1, to lipid rafts following stimulation of antigen receptors
Deming et al., Mol Cell Biol 2004
:
We report here that Bcr-Abl also inhibits caspase activation after the release of cytochrome c.
Bcr-Abl inhibited
caspase activation by cytochrome c added to cell-free lysates and prevented apoptosis when cytochrome c was microinjected into intact cells
Mizuchi et al., Biochem Biophys Res Commun 2005
:
Here we demonstrate that the inducible expression of
BCR/ABL in a murine hematopoietic cell line, TonB210,
leads to the activation of the Ras family small GTPase
Rap1 , which is inhibited by the ABL kinase inhibitor imatinib
Aichberger et al., Blood 2005
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
BCR/ABL dependent expression of
MCL-1 in Ba/F3 cells was counteracted by the mitogen activated protein-kinase/extracellular signal regulated kinase ( MEK ) inhibitor, PD98059, but not by the phosphoinositide 3-kinase inhibitor, LY294002
Fuentes-Pananá et al., J Immunol 2005
:
Ligand induced BCR association with detergent-resistant plasma membrane compartments ( lipid rafts ) has been argued to be essential for initiating and/or sustaining
Igalpha/Igbeta dependent
BCR signaling ... Ligand induced BCR association with detergent-resistant plasma membrane compartments ( lipid rafts ) has been argued to be essential for initiating and/or sustaining
Igalpha/Igbeta dependent
BCR signaling
Saci et al., Mol Cell 2005
:
Here, we show that
RhoA is activated, downstream of PI3K, in
response to
BCR stimulation and is important for BCR dependent calcium flux and cell proliferation
Xu et al., J Interferon Cytokine Res 2005
:
Furthermore, we show that both the
p38 mitogen activated protein kinase ( MAPK ) and the Ca ( 2+ ) /calmodulin dependent kinase ( CaMKII ) are activated in
response to
BCR signaling to converge on Stat1 S727 for maximal gene expression
Weisberg et al., Cancer Cell 2005
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive...) :
Characterization of
AMN107 , a selective
inhibitor of native and mutant
Bcr-Abl
Barnes et al., Oncogene 2005
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
Both IL-3 treatment and expression of
Bcr-Abl led to enhanced phosphorylation of
Akt ( protein kinase B )
Slupianek et al., Oncogene 2005
(Leukemia) :
BCR/ABL promotes interactions of
BLM with RAD51, while simultaneous overexpression of BLM and RAD51 in normal cells increases drug resistance
Geay et al., Cancer Res 2005
(Blast Crisis...) :
However, higher p210 (
BCR-ABL ) expression
induced a marked down-regulation of
CXCR4 that is related to its decreased transcription
Guo et al., J Immunol 2005
:
B cell receptor (BCR) cross-talk : IL-4 creates an alternate pathway for
BCR induced
ERK activation that is phosphatidylinositol 3-kinase independent
Hickey et al., J Leukoc Biol 2005
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
Here, we demonstrate that OPN expression is induced in a model of leukemia, and we describe the identification of specific signaling pathways required for the
induction of
OPN expression by p210
Bcr-Abl
Gadzicki et al., Cancer Genet Cytogenet 2005
(Chromosome Aberrations...) :
We give further evidence that the genomic
BCR-ABL amplification
results in an increased level of
BCR-ABL transcript linking two potent mechanisms of resistance against imatinib treatment ... We give further evidence that the genomic
BCR-ABL amplification
results in an increased level of
BCR-ABL transcript linking two potent mechanisms of resistance against imatinib treatment
Feldhahn et al., J Exp Med 2005
(Calcium Signaling...) :
Acting as a linker, truncated BTK enables
BCR-ABL1 dependent activation of full-length
BTK , which initiates downstream survival signals and mimics a constitutively active pre-B cell receptor
Agirre et al., Cancer Genet Cytogenet 2005
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
Loss of normal BCR in one cell clone may contribute to the resistance to imatinib due to the lack of
BCR mediated inhibition of
BCR-ABL1 ... Loss of normal BCR in one cell clone may contribute to the resistance to imatinib due to the lack of
BCR mediated inhibition of
BCR-ABL1
Francés et al., J Immunol 2005
(Calcium Signaling) :
The same B-1 cells manifested defective
BCR mediated
induction of
IKKbeta phosphorylation, IkappaBalpha degradation, and intracellular Ca ( 2+ ) mobilization ... The same B-1 cells manifested defective
BCR mediated
induction of IKKbeta phosphorylation,
IkappaBalpha degradation, and intracellular Ca ( 2+ ) mobilization
Flamant et al., Biochem Biophys Res Commun 2005
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
Studies using mutant forms of BCR-ABL demonstrated that the
BCR-ABL induced
OPN overexpression was a tyrosine kinase dependent event
Golemovic et al., Clin Cancer Res 2005
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
AMN107 , a novel aminopyrimidine
inhibitor of
Bcr-Abl , has in vitro activity against imatinib-resistant chronic myeloid leukemia
Nakamura et al., Oncogene 2005
(Cell Transformation, Neoplastic...) :
These results indicate that MEKK1 plays a key role in
Bcr-Abl induced
STAT3 activation and in ES cells ' capacity for LIF independent self-renewal, and may thus be involved in Bcr-Abl mediated leukemogenesis in stem cells
Glassford et al., Eur J Immunol 2005
:
Furthermore, using both p85alpha-null and p110delta-null B cells and inhibitors of PI3K, this study demonstrates for the first time, that
BCR cross linking induces cyclin D2 mRNA expression via transcriptional activation of the cyclin D2 promoter and that this transcriptional activation of
cyclin D2 requires PI3K activity ... Furthermore, using both p85alpha-null and p110delta-null B cells and inhibitors of PI3K, this study demonstrates for the first time, that
BCR cross linking induces cyclin D2 mRNA expression via transcriptional activation of the cyclin D2 promoter and that this transcriptional activation of cyclin D2
requires PI3K activity
Xing et al., J Exp Med 2005
:
G5pr(-/-) B cells did not show abnormalities in the
BCR mediated activation of Erks and NF-kappaB,
cyclin D2 induction, or Akt activation ... G5pr(-/-) B cells did not show abnormalities in the
BCR mediated
activation of Erks and NF-kappaB, cyclin D2 induction, or
Akt activation ... G5pr(-/-) B cells did not show abnormalities in the
BCR mediated
activation of Erks and
NF-kappaB , cyclin D2 induction, or Akt activation ... G5pr(-/-) B cells did not show abnormalities in the
BCR mediated activation of Erks and NF-kappaB,
cyclin D2 induction, or Akt activation
Bilancio et al., Blood 2006
:
p110delta activity is indispensable for
BCR induced DNA synthesis and phosphorylation of Akt/protein kinase B (PKB), forkhead
transcription factor/forkhead box O3a (FOXO3a), and p70 S6 kinase (p70 S6K), with modest effects on the phosphorylation of glycogen synthase kinase 3 alpha/beta ( GSK3alpha/beta ) and extracellular signal regulated kinase ( Erk ) ... p110delta activity is indispensable for
BCR induced DNA synthesis and phosphorylation of Akt/protein kinase B (PKB), forkhead transcription
factor/forkhead box O3a (FOXO3a) , and p70 S6 kinase (p70 S6K), with modest effects on the phosphorylation of glycogen synthase kinase 3 alpha/beta ( GSK3alpha/beta ) and extracellular signal regulated kinase ( Erk ) ... p110delta activity is indispensable for
BCR induced DNA synthesis and phosphorylation of
Akt/protein kinase B (PKB) , forkhead transcription factor/forkhead box O3a (FOXO3a), and p70 S6 kinase (p70 S6K), with modest effects on the phosphorylation of glycogen synthase kinase 3 alpha/beta ( GSK3alpha/beta ) and extracellular signal regulated kinase ( Erk ) ... p110delta activity is indispensable for
BCR induced DNA synthesis and phosphorylation of
Akt/protein kinase B (PKB), forkhead transcription factor/forkhead box O3a (FOXO3a), and p70 S6 kinase (p70 S6K), with modest effects on the phosphorylation of glycogen synthase kinase 3 alpha/beta ( GSK3alpha/beta ) and extracellular signal regulated kinase ( Erk ) ... p110delta activity is indispensable for
BCR induced DNA synthesis and phosphorylation of Akt/protein kinase B (PKB), forkhead transcription factor/forkhead box O3a (FOXO3a), and
p70 S6 kinase (p70 S6K) , with modest effects on the phosphorylation of glycogen synthase kinase 3 alpha/beta ( GSK3alpha/beta ) and extracellular signal regulated kinase ( Erk )
Ress et al., EMBO Rep 2005
:
Expression of
Bcr in the human colon carcinoma cell line HCT116, which has a high level of endogenous beta-catenin,
leads to reduced
c-Myc expression
Neviani et al., Cancer Cell 2005
(Blast Crisis...) :
In imatinib-sensitive and -resistant ( T315I included ) BCR/ABL+ cell lines and CML-BC progenitors, molecular and/or pharmacological activation of
PP2A promotes dephosphorylation of key regulators of cell proliferation and survival,
suppresses BCR/ABL activity, and induces BCR/ABL degradation ... In imatinib-sensitive and -resistant ( T315I included ) BCR/ABL+ cell lines and CML-BC progenitors, molecular and/or pharmacological activation of PP2A promotes dephosphorylation of key regulators of cell proliferation and survival, suppresses
BCR/ABL activity, and
induces BCR/ABL degradation
Xu et al., J Immunol 2005
:
Specifically for an anti-microbial response, the recognition of viral or bacterial Ags by the
BCR and the
stimulation of
IFN-gamma result in the predominant production of IgG2a
Giles et al., Curr Mol Med 2005
(Hematologic Neoplasms...) :
FLT3 , VEGF, and
BCR-ABL mediate their activities via mTOR
Lee et al., J Immunol 2005
:
BCR induced
CD22 phosphorylation and Src homology 2 domain containing protein tyrosine phosphatase-1/CD22 associations were also reduced, suggesting abrogation of negative regulatory signaling
Khan et al., Infect Immun 2006
:
The relative role of
Btk dependent
B-cell receptor (BCR) signaling in the induction of antipolysaccharide ( anti-PS ) and antiprotein immunoglobulin ( Ig ) responses to an intact extracellular bacterium in vivo is unknown
Clark et al., Oncology 2006
(Leukemia) :
Since
Bcr/Abl induces constitutive expression of
c-Myc , which is necessary for cell cycle transit from G1 into the S phase, we tested whether POH causes growth arrest by inhibiting expression of c-Myc
Nieborowska-Skorska et al., Cancer Res 2006
(Cell Transformation, Neoplastic...) :
We show here that expression of the helix-loop-helix transcription factor
Id1 is
enhanced by
BCR/ABL in a signal transducer and activator of transcription 5 ( STAT5 ) -dependent manner
Wendel et al., Proc Natl Acad Sci U S A 2006
(Disease Progression...) :
We show that the
tumor suppressor p53 is selectively activated by imatinib in BCR-ABL expressing cells as a
result of
BCR-ABL kinase inhibition
Siegel et al., Cell 2006
:
This study indicates that
OCA-B is
required for
pre-BCR and BCR signaling at multiple stages of B cell development through its nontranscriptional regulation of SYK
de la Fuente et al., Mol Cell Biol 2006
:
B-cell proliferation, cell cycle progression, PLC-gamma2 phosphorylation, calcium mobilization, NF-ATp dephosphorylation, and
Erk and Jnk activation in
response to
B-cell receptor (BCR) ligation were all impaired
Gazumyan et al., J Exp Med 2006
:
BCR cross linking
resulted in decreased
Src and Syk activation but paradoxically enhanced and prolonged BCR signaling, as measured by cellular tyrosine phosphorylation, Ca ( ++ ) flux, AKT, and ERK activation ...
BCR cross linking
resulted in decreased Src and
Syk activation but paradoxically enhanced and prolonged BCR signaling, as measured by cellular tyrosine phosphorylation, Ca ( ++ ) flux, AKT, and ERK activation
Irish et al., Blood 2006
(Lymphoma, B-Cell...) :
The
B-cell receptor (BCR) transmits life and death signals throughout B-cell development, and altered
BCR signaling may be
required for survival of B-lymphoma cells
Coppo et al., Br J Haematol 2006
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
BCR-ABL activates
STAT3 via JAK and MEK pathways in human cells
Aichberger et al., Blood 2006
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
The CML related oncoprotein
BCR/ABL induces expression of
histidine decarboxylase (HDC) and the synthesis of histamine in leukemic cells
Snyder et al., Traffic 2006
:
Thus, the investigation of the mechanism by which Y112-LMP2A blocks BCR function revealed an essential
role for
PLD in
BCR trafficking for antigen processing
Chen et al., Blood 2006
(Lymphoma) :
BCR dependent activation of the SYK
PTK initiates downstream signaling events and amplifies the original BCR signal
Prabhu et al., Oncogene 2007
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
In this study, we found that both
Bcr-Abl and the rapamycin-sensitive mTORC1 complex
contribute to the phosphorylation ( inactivation ) of
4E-BP1 , an inhibitor of the eIF4E translation initiation factor ... Experiments with rapamycin and the Bcr-Abl inhibitor, imatinib mesylate, in Bcr-Abl expressing cell lines and primary CML cells indicated that
Bcr-Abl and mTORC1
induced formation of the translation initiation complex,
eIF4F
Sengupta et al., J Gene Med 2006
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive...) :
BCR-ABL mediated chronic myelogenous leukemia ( CML )
CD34 ( + ) cell proliferation mostly depends on the nucleo-cytoplasmic ratio of the cyclin dependent kinase inhibitor p27
Gobessi et al., Blood 2007
(Leukemia, B-Cell...) :
We show that
BCR mediated activation of
ZAP-70 is very inefficient in CLL and lymphoma B cells and is negligible when compared to activation of Syk
Pappu et al., Eur J Immunol 2006
:
NF-kappaB activation through
B cell receptor (BCR) ligation is critical for B cell development, survival and antigen mediated activation of B cells
Ke et al., J Biol Chem 2006
(Lymphoma, B-Cell...) :
Cross linking of the
B cell receptor (BCR) on the immature B lymphoma cell line BKS-2
induces growth inhibition and apoptosis accompanied by rapid down-regulation of the immediate-early gene
egr-1 ...
BCR induced
MAPK activation was modest and transient with a small increase in egr-1 expression in normal immature B cells consistent with their inability to proliferate in response to BCR cross linking
Dragone et al., Proc Natl Acad Sci U S A 2006
:
Coexpression of SLAP and
c-Cbl in Bal-17
led to decreased surface and total
BCR levels
Caballero et al., Eur J Immunol 2006
:
The results demonstrate that Src kinases and
Syk mediated
BCR signaling are not essential for BCR mediated Ag internalization
Wang et al., Oncogene 2007
:
Engagement of the
B-cell antigen receptor (BCR) initiated by the Src kinase
Lyn triggers rapid signaling cascades, leading to proliferation, differentiation or growth arrest of B cells
Iotti et al., Oncogene 2007
(Leukemia, Myeloid) :
Expression of
CCL9/MIP-1gamma is
repressed by
BCR/ABL and its restoration suppresses in vivo leukemogenesis of 32D-BCR/ABL cells ... Expression of
CCL9/MIP-1gamma is
repressed by
BCR/ABL and its restoration suppresses in vivo leukemogenesis of 32D-BCR/ABL cells ... Expression of
CCL9/MIP-1gamma is
repressed by
BCR/ABL and its restoration suppresses in vivo leukemogenesis of 32D-BCR/ABL cells ...
BCR/ABL repressed
CCL9 expression at the transcriptional level by mechanisms involving suppression of p38 MAP kinase, and modulation of the activity of CDP/cut and C/EBPalpha, two transcription regulators of myeloid differentiation
Storch et al., Eur J Immunol 2007
:
We show that the
Ig-alpha mutants
led to comparable
pre-BCR expression on the cell surface, while the pre-BCR induced tyrosine phosphorylation was different
Kantarjian et al., Ann Intern Med 2006
(Disease Progression...) :
In light of the limitations of imatinib against these factors, newer tyrosine kinase inhibitors, including dasatinib ( a multitargeted kinase inhibitor of BCR-ABL and Src family kinases ) and nilotinib (
AMN107 , a selective
BCR-ABL inhibitor ), may provide promising treatment options for patients with CML
Hinman et al., J Immunol 2007
:
Previously,
BCR induced phosphorylation of
FOXO1 was shown to lead to a block in nuclear localization and subsequent protein degradation
Moriyama et al., Immunol Lett 2007
(Lymphoma, B-Cell) :
Rapid
up-regulation of
c-FLIP expression by
BCR signaling through the PI3K/Akt pathway inhibits simultaneously induced Fas mediated apoptosis in murine B lymphocytes
Coluccia et al., EMBO J 2007
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
Bcr-Abl stabilizes
beta-catenin in chronic myeloid leukemia through its tyrosine phosphorylation ... These findings indicate the
Bcr-Abl triggered Y phosphorylation of
beta-catenin as a new mechanism responsible for its protein stabilization and nuclear signalling activation in CML
Alugupalli et al., J Immunol 2007
(Borrelia Infections) :
These results suggest that
MyD88 specifically
promotes T cell independent
BCR signaling and that, in the absence of Btk, this TLR mediated stimulation is a required component of this signal
Thompson et al., Immunity 2007
:
Thus,
pre-BCR signaling
regulates Aiolos and the silencing of
Igll1 via a developmental-stage-specific feedback loop
Perrotti et al., Clin Cancer Res 2007
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive...) :
Here, we summarize the
effects of increased
BCR/ABL oncogenic activity on the expression and function of RNA binding proteins ( e.g., FUS, hnRNP A1, hnRNP E2, hnRNP K, and
La/SSB ) with posttranscriptional and translational regulatory activities and their importance for the phenotype of BCR/ABL transformed hematopoietic progenitors ... Here, we summarize the
effects of increased
BCR/ABL oncogenic activity on the expression and function of RNA binding proteins ( e.g.,
FUS , hnRNP A1, hnRNP E2, hnRNP K, and La/SSB ) with posttranscriptional and translational regulatory activities and their importance for the phenotype of BCR/ABL transformed hematopoietic progenitors ... Here, we summarize the
effects of increased
BCR/ABL oncogenic activity on the expression and function of RNA binding proteins ( e.g., FUS,
hnRNP A1 , hnRNP E2, hnRNP K, and La/SSB ) with posttranscriptional and translational regulatory activities and their importance for the phenotype of BCR/ABL transformed hematopoietic progenitors ... Here, we summarize the
effects of increased
BCR/ABL oncogenic activity on the expression and function of RNA binding proteins ( e.g., FUS, hnRNP A1, hnRNP E2,
hnRNP K , and La/SSB ) with posttranscriptional and translational regulatory activities and their importance for the phenotype of BCR/ABL transformed hematopoietic progenitors ... Here, we summarize the
effects of increased
BCR/ABL oncogenic activity on the expression and function of RNA binding proteins ( e.g., FUS, hnRNP A1,
hnRNP E2 , hnRNP K, and La/SSB ) with posttranscriptional and translational regulatory activities and their importance for the phenotype of BCR/ABL transformed hematopoietic progenitors
Angyal et al., Ann N Y Acad Sci 2006
:
RNA silencing experiments showed that knocking down Gab1 adaptor protein in BL41 human Burkitt lymphoma cells significantly reduced
B cell receptor (BCR) induced
Erk phosphorylation, indicating that Gab1 plays a pivotal role in regulating Erk activity in B cells
Li et al., J Cell Sci 2007
:
Expression of
Bcr-Abl induces tyrosine phosphorylation of
Abi1 ...
Bcr-Abl induced membrane translocation of
Abi1/WAVE2 requires direct interaction between Abi1 and Bcr-Abl, but is independent of the phosphoinositide 3-kinase pathway ...
Bcr-Abl induced membrane translocation of
Abi1/WAVE2 requires direct interaction between Abi1 and Bcr-Abl, but is independent of the phosphoinositide 3-kinase pathway
Rechsteiner et al., J Gen Virol 2007
(Burkitt Lymphoma) :
Epstein-Barr virus ( EBV )
latent membrane protein 2A (LMP2A) blocks
B-cell receptor (BCR) signalling after BCR cross linking to inhibit activation of lytic EBV, and ectopically expressed LMP2B negatively regulates LMP2A
Rink et al., Blood 2007
(Leukemia) :
Here we show that
BCR/ABL stimulated
Nbs1 expression by induction of c-Myc dependent transactivation and protection from caspase dependent degradation
Chang et al., Blood 2007
(Blast Crisis...) :
In fact, high levels of
p210-BCR/ABL are
required for enhanced
hnRNP-E2 expression, which depends on phosphorylation of hnRNP-E2 serines 173, 189, and 272 and threonine 213 by the BCR/ABL activated MAPK(ERK1/2)
Poincloux et al., J Cell Physiol 2007
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
In chronic myeloid leukemia ( CML ), the transforming activity of
Bcr/Abl involves constitutive activation of the phagocyte specific Src-family tyrosine kinase
Hck , which in turn directly activates the signal transducer and activator of transcription 5 ( STAT5 )
Kohl et al., Leukemia 2007
(Acute Disease...) :
In contrast to AML cell lines, BCR-ABL transformed human cells showed resistance to ABT-737, which might be due to the
induction of
MCL1 by
BCR-ABL
Beaulieu et al., Mol Biol Cell 2007
(Cell Transformation, Neoplastic) :
We found that the C1 domain can contribute to plasma membrane targeted translocation of
RasGRP1 induced by ligation of the
B cell antigen receptor (BCR)
Bai et al., Mol Cell Biol 2007
:
Phospholipase Cgamma2 ( PLCgamma2 ) is
critical for pre-B-cell receptor ( pre-BCR ) and
BCR signaling ... Importantly, PLCgamma2 deficiency impaired
BCR induced expression of IRF-4 and
IRF-8 , the two transcription factors critical for lambda and kappa light-chain rearrangements ... Importantly, PLCgamma2 deficiency impaired
BCR induced expression of
IRF-4 and IRF-8, the two transcription factors critical for lambda and kappa light-chain rearrangements
Li et al., Oncogene 2007
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
Our data indicated that
BCR/ABL induces
SPK1 expression and increases its cellular activity, leading to upregulation of Mcl-1 in CML cells ... Our data indicated that
BCR/ABL induces SPK1 expression and increases its cellular activity,
leading to upregulation of
Mcl-1 in CML cells
Yu et al., Biochem Biophys Res Commun 2007
:
Previous studies demonstrated that synthetic sialosides that bind to CD22 augment BCR signaling by inhibiting
CD22 mediated
BCR regulation
Chu et al., Cancer Res 2007
(Cell Transformation, Neoplastic...) :
BCR/ABL expression results in enhanced Ras and Akt activity but
reduced mitogen activated protein kinase activity in human hematopoietic cells, which is reversed by BCR/ABL-Y177 mutation ...
BCR/ABL expression
results in enhanced Ras and
Akt activity but reduced mitogen activated protein kinase activity in human hematopoietic cells, which is reversed by BCR/ABL-Y177 mutation
Avramidou et al., Cell Death Differ 2007
:
The novel adaptor protein
Swiprosin-1 enhances
BCR signals and contributes to BCR induced apoptosis
Craxton et al., Eur J Immunol 2007
:
Likewise,
BCR induced
p27 ( Kip1 ) degradation was decreased in Bim KO compared to WT B cells
Donahue et al., Eur J Immunol 2007
:
We used flow cytometry and magnetic cell sorting to examine the requirement for PI3K and
mTOR in
responses of splenic B cell subsets to
BCR and LPS stimulation ... We used flow cytometry and magnetic cell sorting to examine the requirement for
PI3K and mTOR in
responses of splenic B cell subsets to
BCR and LPS stimulation
Brezski et al., J Immunol 2007
:
In this study, we show that in mature B cells,
BCR signaling
triggers Vav phosphorylation and Rac1 activation ... Because transitional immature murine B cells maintain lower steady-state levels of plasma membrane cholesterol, we augmented their levels to that of mature B cells and found that
BCR induced
Rac1 activation and Rac1 dependent membrane ruffling and cell spreading were restored
Sahay et al., Oncogene 2008
(Cell Transformation, Neoplastic...) :
p210
Bcr-Abl can
stimulate RhoA activation independently of its tyrosine kinase activity, and mutations within the RhoGEF domain that are predicted to eliminate RhoGEF activity inhibit RhoA activation
Chen et al., Blood 2008
(Lymphoma, Large B-Cell, Diffuse) :
Ligand induced
BCR signaling
induces receptor oligomerization, Igalpha/beta immunoreceptor tyrosine based activation motif ( ITAM ) phosphorylation, and activation of the
spleen tyrosine kinase (SYK) , which initiates downstream events and amplifies the initial BCR signal
Zhu et al., J Biol Chem 2008
:
We demonstrate that the
CD22 mutant in which both Tyr ( 843 ) and Tyr ( 863 ) are replaced by phenylalanine ( CD22F5/6 ) recruits SHP-1 and
regulates BCR signaling upon stimulation with antigen but not anti-Ig Ab
Hussain et al., J Immunol 2007
(Diabetes Mellitus, Type 1) :
Consistent with this result, severe insulitis was observed in the islets of NOD recipients of transfused
NOD.IL-10 ( -/- )
BCR stimulated B cells but not in the islets of NOD recipients of transfused BCR stimulated NOD B cells ... Consistent with this result, severe insulitis was observed in the islets of NOD recipients of transfused
NOD.IL-10 ( -/- )
BCR stimulated B cells but not in the islets of NOD recipients of transfused BCR stimulated NOD B cells
Konig et al., Blood 2008
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
SKI-606 effectively
inhibited Bcr-Abl kinase activity in CML CD34 ( + ) cells and inhibited Src phosphorylation more potently than imatinib ... SKI-606 effectively inhibited
Bcr-Abl kinase activity in CML CD34 ( + ) cells and
inhibited Src phosphorylation more potently than imatinib
Shinohara et al., J Exp Med 2007
:
We show that PKCbeta mediates phosphorylation of CARMA1 on Ser668, which in turn is essential for
BCR mediated CARMA1-Bcl10-mucosal associated lymphoid tissue 1 ( MALT1 ) association and subsequent
IKK activation
Sohn et al., J Immunol 2008
:
That lipid rafts play a role in
FcgammaRIIB 's
regulation of
BCR signaling was suggested by recent studies showing that a lupus associated loss of function mutation resulted in the receptor 's exclusion from lipid rafts and the failure to regulate BCR signaling
Ban et al., Blood 2008
(Blast Crisis...) :
BCR-ABL1 mediates up-regulation of
Fyn in chronic myelogenous leukemia
Mättö et al., Scand J Immunol 2008
:
BCR stimulation also stabilized and
enhanced the
IFN-gamma mRNA production induced by IL-12 and IL-18
Duncan et al., Mol Cancer Ther 2008
:
Additionally, we reported previously that
BCR-ABL activates the transcription factor
nuclear factor-kappaB (NF-kappaB) in a manner dependent on Ras and that inhibition of NF-kappaB by expression of a modified form of IkappaBalpha blocked BCR-ABL-driven tumor growth in a xenograft model ... These data indicate that blockage of
BCR-ABL induced
NF-kappaB activation via IkappaB kinase beta inhibition represents a potential new approach for treatment of Imatinib- or Dasatinib-resistant forms of chronic myelogenous leukemia
Lakshmikuttyamma et al., Oncogene 2008
(Blast Crisis...) :
Bcr-Abl induces autocrine
IGF-1 signaling
Onabajo et al., J Immunol 2008
:
Mutations of the two tyrosine phosphorylation sites of Abp1 and depolymerization of the actin cytoskeleton interfered with
BCR induced
Abp1 recruitment to the plasma membrane ... These results demonstrate that the
BCR regulates the function of Abp1 by inducing
Abp1 phosphorylation and actin cytoskeleton rearrangement, and that Abp1 facilitates BCR mediated Ag processing by simultaneously interacting with dynamin and the actin cytoskeleton
Lee et al., Journal of cell communication and signaling 2007
:
In contrast,
BCR induced activation of ERK, JNK,
p38 , and Akt was not affected by ROS depletion ... In contrast,
BCR induced activation of
ERK , JNK, p38, and Akt was not affected by ROS depletion ... In contrast,
BCR induced
activation of ERK, JNK, p38, and
Akt was not affected by ROS depletion
Bueno et al., Cancer Cell 2008
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive...) :
Genetic and epigenetic silencing of
microRNA-203 enhances ABL1 and
BCR-ABL1 oncogene expression
Wu et al., J Natl Cancer Inst 2008
(Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative) :
LYN activation was
independent of
BCR-ABL in cells from imatinib-resistant patients
Ha et al., J Leukoc Biol 2008
:
We found that in CB B cells
activation of extracellular signal regulated kinase ( ERK ) and
p38 following ligation of CD40 but not of the
B-cell antigen receptor (BCR) was inefficient ... We found that in CB B cells
activation of extracellular signal regulated kinase (
ERK ) and p38 following ligation of CD40 but not of the
B-cell antigen receptor (BCR) was inefficient
Bhattacharyya et al., Ann Hematol 2009
(Blast Crisis...) :
Since we further found that overexpression of
BCR-ABL in human embryonic kidney-293 cells enhanced BMI-1 expression and that
BMI-1 expression was
increased in K562 cells, derived from patients with BC, in the presence of proteasomal inhibitors, BMI-1 was presumed to be positively regulated by BCR-ABL and further by posttranscriptional modification in the course of the disease progression
Crowley et al., Blood 2009
:
These studies investigate how interactions between the
BCR and FcgammaRIIB
affect B lymphocyte stimulator (BLyS) recep-tor expression and signaling
Yi et al., Int J Mol Med 2008
(Precursor Cell Lymphoblastic Leukemia-Lymphoma) :
The binding of
Bcr/Abl to Spa-1 may
cause aberrant subcellular location of
Spa-1 and affect migration of these cells
Minguet et al., Eur J Immunol 2008
:
Our data suggest that TLR4 and
BCR induce
CD69 transcription via two distinct sets of signalling molecules, exerting quantitative and qualitative differences in B-cell activation
Li et al., Arthritis Rheum 2008
(Autoimmune Diseases) :
Biochemical analyses indicated that in anergic B cells,
CD72 dominantly
down-regulated BCR signaling to limit the antigen induced elevation in [ Ca2+ ] i and the activation of NFATc1, NF-kappaB, MAPK, and Akt ... Mechanistically, CD72 was associated with, and regulated, the molecular adaptor Cbl-b in anergic B cells, suggesting that Cbl-b may play a role in mediating the negative
effects of
CD72 on
BCR signaling
Konig et al., Cancer Res 2008
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
In contrast, Imatinib inhibited only
Bcr-Abl dependent
Src activity
Mahon et al., Cancer Res 2008
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
Two
Src kinase inhibitors ( PP1 and PP2 ) partially removed resistance but did not significantly
inhibit Bcr-Abl tyrosine kinase activity ... In contrast, dasatinib, a dual
Bcr-Abl and Src kinase inhibitor,
inhibited the phosphorylation of both
BCR-ABL and Lyn, and induced apoptosis of the Bcr-Abl cell line overexpressing p53/56 Lyn ... In contrast, dasatinib, a dual Bcr-Abl and
Src kinase inhibitor,
inhibited the phosphorylation of both
BCR-ABL and Lyn, and induced apoptosis of the Bcr-Abl cell line overexpressing p53/56 Lyn ... In contrast, dasatinib, a dual
Bcr-Abl and Src kinase inhibitor,
inhibited the phosphorylation of both
BCR-ABL and Lyn, and induced apoptosis of the Bcr-Abl cell line overexpressing p53/56 Lyn
Gobessi et al., Leukemia 2009
(Leukemia, Lymphocytic, Chronic, B-Cell) :
In addition, R406 prevented the increase in leukemic cell viability induced by sustained BCR engagement and inhibited
BCR induced
Akt activation and Mcl-1 upregulation ... In addition, R406 prevented the increase in leukemic cell viability induced by sustained BCR engagement and inhibited
BCR induced Akt activation and
Mcl-1 upregulation
Gao et al., J Biol Chem 2009
:
Here we identify the transcription factors that drive redox- and
BCR-ABL1 dependent
Fyn expression ... Our work is the first to define transcription factors that are responsible for endogenous, oxidative stress dependent and
BCR-ABL1 dependent
Fyn expression
Järås et al., Exp Hematol 2009
:
By using a lentiviral anti-signal transducer and activator of transcription 5 ( STAT5 ) short-hairpin RNA, we found that both P190
BCR/ABL1- and P210 BCR/ABL1 induced erythroid cell expansion were
STAT5 dependent
Schuman et al., Blood 2009
:
However, the role of TAK1 in
B-cell receptor (BCR) mediated
NF-kappaB activation and B-cell development is not clear ... Thus, TAK1 is critical for B-cell maturation and
BCR induced
NF-kappaB activation
Jacobson et al., Mol Immunol 2009
:
Prolonged activation of B cells via cross linking of the
BCR ( but not CR1/CR2 alone )
leads to increased expression of
Pcp4 and suppressed Ca ( 2+ ) release
Hodson et al., Adv Exp Med Biol 2009
:
Although CD40, TLR and cytokines all activate PI3K the
BCR seems especially
dependent upon
PI3K signalling
Mancini et al., Traffic 2009
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
In particular, constitutive tyrosine kinase ( TK ) activity of p210
BCR-ABL blocks
c-Jun N-terminal kinase (JNK) phosphorylation leading to 14-3-3 sigma phosphorylation at a critical residue ( Ser ( 186 ) ) for c-ABL binding in response to DNA damage
Hirano et al., J Biol Chem 2009
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
The Abl kinase inhibitors and depletion of
Bcr-Abl induced the expression of
PHLPP1 and PHLPP2, which dephosphorylated Ser-473 on Akt1, -2, and -3, resulting in inhibited proliferation of CML cells ... The Abl kinase inhibitors and depletion of
Bcr-Abl induced the expression of PHLPP1 and
PHLPP2 , which dephosphorylated Ser-473 on Akt1, -2, and -3, resulting in inhibited proliferation of CML cells ... Thus,
Bcr-Abl represses the expression of
PHLPP1 and PHLPP2 and continuously activates Akt1, -2, and -3 via phosphorylation on Ser-473, resulting in the proliferation of CML cells ... Thus,
Bcr-Abl represses the expression of PHLPP1 and
PHLPP2 and continuously activates Akt1, -2, and -3 via phosphorylation on Ser-473, resulting in the proliferation of CML cells ... Thus,
Bcr-Abl represses the expression of PHLPP1 and PHLPP2 and continuously
activates Akt1 , -2, and -3 via phosphorylation on Ser-473, resulting in the proliferation of CML cells
Henry et al., J Immunol 2009
(Calcium Signaling) :
These include
BCR down-regulation, impaired proliferative
responses to
anti-CD40 , and diminished calcium mobilization upon stimulation with BCR dependent and independent stimuli
Geahlen et al., Biochim Biophys Acta 2009
:
The
B cell receptor (BCR) transduces antigen binding into alterations in the activity of intracellular signaling pathways through its ability to recruit and
activate the cytoplasmic protein-tyrosine kinase
Syk
Gross et al., J Immunol 2009
:
Wild-type mature follicular B cells were less sensitive to BCR stimulation than were immature transitional stage 1 B cells with regard to
BCR induced calcium elevation and ERK
MAPK activation ... Wild-type mature follicular B cells were less sensitive to BCR stimulation than were immature transitional stage 1 B cells with regard to
BCR induced calcium elevation and
ERK MAPK
activation
Li et al., J Int Med Res 2009
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
Studies have shown that
vascular endothelial growth factor ( VEGF ), a major and potent inducer of angiogenesis, is directly
triggered by the disease related oncogene
Bcr-Abl in Bcr-Abl positive cells
Quiroga et al., Blood 2009
(Leukemia, Lymphocytic, Chronic, B-Cell) :
Finally, R406 inhibited constitutive and
BCR induced activation of
Syk , extracellular signal regulated kinases, and AKT, and blocked BCR induced calcium mobilization ... Finally, R406 inhibited constitutive and
BCR induced
activation of Syk, extracellular signal regulated kinases, and
AKT , and blocked BCR induced calcium mobilization
Baudot et al., Oncogene 2009
(Leukemia, Lymphocytic, Chronic, B-Cell) :
Recent evidence pointing to a critical
role of
spleen tyrosine kinase (Syk) in ligand independent
BCR signaling prompted us to examine its role in primary B-CLL cell survival
Jackson et al., J Immunol 2009
(Hypersensitivity) :
To begin to understand physiologic determinants of CD23 expression, we analyzed
effects of
BCR and TLR stimulation on
CD23 levels
Vlad et al., Cancer Res 2009
(Disease Progression...) :
BCR stimulation
promoted a strictly simultaneous down-regulation of CXCR4 and
CD62L membrane expression to a variable extent ...
BCR stimulation
promoted a strictly simultaneous down-regulation of
CXCR4 and CD62L membrane expression to a variable extent ... Functionally, cells down regulating CXCR4 and
CD62L in
response to
BCR engagement displayed a reduction in both migration toward CXCL12 and adhesion to lymphatic endothelial cells ... Functionally, cells down regulating
CXCR4 and CD62L in
response to
BCR engagement displayed a reduction in both migration toward CXCL12 and adhesion to lymphatic endothelial cells
Haas et al., J Immunol 2009
:
Reducing CD19 expression in CD21/35 ( -/- ) mice normalized
BCR induced calcium responses,
PD-1 induction, and PPS-3-specific IgG3 responses and restored protection during S. pneumoniae infection
Oak et al., Autoimmunity 2009
:
BCR mediated
AKT phosphorylation is partially reduced in p85alpha-deficient B cells and further diminished with concomitant loss of p85beta
Hoek et al., J Immunol 2009
(Lymphopenia) :
Recent studies have shown that
BCR signaling positively
regulates NF-kappaB2 , suggesting BCR regulation of BR3 signaling
Durand et al., J Immunol 2009
:
In these innate-like B cells,
p110delta activity
mediates BCR- , TLR- and chemoattractant induced activation of the Akt prosurvival kinase, chemoattractant induced migration, and TLR induced proliferation
Juszczynski et al., Blood 2009
(Lymphoma, Large B-Cell, Diffuse) :
Herein, we evaluated potential connections between BCL6 mediated transcriptional repression and
SYK dependent
BCR signaling
Donato et al., Biochem Pharmacol 2010
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
Aurora and
BCR-ABL kinase inhibition were consistently measured at 20-100 nM and 2-10 microM MK-0457, respectively, but expression of
T315I-BCR-ABL and overexpression of Lyn kinase
reduced MK-0457 sensitivity
Richards et al., Eur J Immunol 2009
:
BCR ligation
leads to a more rapid decrease in
p27 ( Kip1 ) levels in gp91(phox) KO B cells
Takemura et al., J Biol Chem 2010
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
Thus,
Bcr-Abl represses the expression of RKIP, continuously activates pERK1/2, and
suppresses FoxM1 expression, resulting in proliferation of CML cells ... Thus,
Bcr-Abl represses the expression of
RKIP , continuously activates pERK1/2, and suppresses FoxM1 expression, resulting in proliferation of CML cells ... Thus,
Bcr-Abl represses the expression of RKIP, continuously
activates pERK1/2 , and suppresses FoxM1 expression, resulting in proliferation of CML cells
Preisinger et al., Cell Signal 2010
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
The binding of GADS to
Bcr-Abl requires
Bcr-Abl tyrosine kinase activity and is sensitive to the Bcr-Abl inhibitor imatinib, while the GADS/Slp-76 and Slp-76/Nck interactions are tyrosine phosphorylation independent ... The binding of GADS to
Bcr-Abl requires
Bcr-Abl tyrosine kinase activity and is sensitive to the Bcr-Abl inhibitor imatinib, while the GADS/Slp-76 and Slp-76/Nck interactions are tyrosine phosphorylation independent
Ishiura et al., Eur J Immunol 2010
(Lymphoma, B-Cell) :
BCR engagement
induced differential tyrosine phosphorylation, as CD19-Y ( 513 ) phophorylation occurred first, and
CD19-Y ( 482 ) phosphorylation was delayed and transient ... Different BCR isotypes exhibited distinct patterns of CD19 phosphorylation :
IgG-BCR ligation
resulted in faster phosphorylation of
CD19-Y ( 513 ) and more intense phosphorylation of CD19-Y ( 391 ) than IgM-BCR ligation
Gleixner et al., Cancer Res 2010
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
Inhibition of
BCR/ABL by imatinib or nilotinib ( AMN107 )
led to decreased expression of the
Plk1 protein in CML cells, suggesting that BCR/ABL promotes Plk1 generation
Chu et al., Leukemia 2010
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
These studies show the importance of
BCR-ABL-Y177-AKT mediated
p27 phosphorylation in altered p27 localization and enhanced proliferation and expansion of primary CML progenitors
Malin et al., Curr Opin Immunol 2010
(Precursor Cell Lymphoblastic Leukemia-Lymphoma) :
STAT5 also plays a key role in the generation of B cell precursor acute lymphoblastic leukemia, whereby the
BCR-ABL1 translocation or the collaboration of JAK2 mutations with overexpression of the thymic stromal lymphopoietin receptor CRLF2
results in constitutive
STAT5 activation leading to cytokine independent survival and growth of leukemic cells
Vidovic et al., Leukemia 2010
(Leukemia) :
In this study, we show that overexpression of
BCR/ABL1 in CD34+ progenitor cells
leads to reduced expression of
interferon regulatory factor 8 (IRF8) , in addition to increased WT1 expression
Hagn et al., Eur J Immunol 2010
(Lupus Erythematosus, Systemic) :
IL-21 directly induced
GzmB expression and secretion by CD5 ( + ) B cells from several AD and from cord blood in vitro, and the simultaneous presence of
BCR stimulation strongly
enhanced this process
Wolanin et al., Mol Cancer Ther 2010
(Aneuploidy...) :
Bcr-Abl leads to decreased expression of genes involved in the mitotic checkpoint activation -- Mad2,
Bub1 , Bub3, and BubR1, resulting in mitosis perturbances, weakened mitotic checkpoint function, and mitotic slippage after nocodazole treatment ...
Bcr-Abl leads to decreased expression of genes involved in the mitotic checkpoint activation -- Mad2, Bub1,
Bub3 , and BubR1, resulting in mitosis perturbances, weakened mitotic checkpoint function, and mitotic slippage after nocodazole treatment
Pene-Dumitrescu et al., J Biol Chem 2010
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
NaPP1 also
reduced Hck mediated phosphorylation of
Bcr-Abl at sites that may affect imatinib sensitivity exclusively in cells expressing Hck-T338A ... NaPP1 also reduced
Hck mediated phosphorylation of
Bcr-Abl at sites that may affect imatinib sensitivity exclusively in cells expressing Hck-T338A
Honigberg et al., Proc Natl Acad Sci U S A 2010
(Arthritis, Experimental...) :
The
Bruton tyrosine kinase (Btk) is specifically
required for
BCR signaling as demonstrated by human and mouse mutations that disrupt Btk function and prevent B-cell maturation at steps that require a functional BCR pathway
Sugalski et al., J Immunol 2010
(Hepatitis C...) :
We observed intact or enhanced tetanus-specific and total IgG ASC frequency, serum IgG,
BCR- and CD40L dependent CD80/CD86 expression, and
CD40L dependent bulk B cell
activation of memory CD4 cells in HCV infection
Ramadani et al., Science signaling 2010
:
Unlike p110delta, however,
p110alpha did not
contribute to agonist induced
BCR signaling
Rowland et al., J Immunol 2010
:
Additionally, we show that
BAFF is essential for the differentiation of CD23 ( - ) into CD23 ( + ) transitional B cells both in vitro and in vivo through a mechanism distinct from that mediating cell survival, but
requiring tonic
BCR signaling
Oh et al., J Neurosci 2010
(Synaptic Transmission) :
Regulation of synaptic
Rac1 activity, long-term potentiation maintenance, and learning and memory by
BCR and ABR Rac GTPase activating proteins ... These results suggest that
BCR and ABR have novel roles in the regulation of synaptic Rac1 signaling, synaptic plasticity, and learning and memory, and that excessive
Rac1 activity negatively
affects synaptic and cognitive functions
Modi et al., Leukemia 2011
(Cell Transformation, Neoplastic...) :
We conclude that inhibition of Grb2 expression demonstrates an important role in
BCR-ABL mediated
MAPK activation and transformation of primary human hematopoietic cells.These results support further investigation of downstream effectors of Grb2 mediated signals and targeting of Grb2 interactions in the treatment of CML
Ying et al., Immunobiology 2011
:
It has been shown that CD40 stimulation can augment BCR induced B cell responses, but the molecular mechanism ( s ) by which
CD40 regulates
BCR signaling is poorly understood
Kelly et al., J Cell Mol Med 2011
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
In contrast to other Aurora kinase inhibitors,
MLN8237 did not significantly
affect BCR-ABL activity
Thai et al., Leukemia 2011
(Cell Transformation, Neoplastic...) :
We resolve this paradox, demonstrating that
BCR-ABL1 kinase activity is
regulated by
RIN1 , an ABL SH3/SH2 binding protein
Mao et al., Proc Natl Acad Sci U S A 2010
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
As4S4 targets RING-type E3 ligase
c-CBL to
induce degradation of
BCR-ABL in chronic myelogenous leukemia
Slupianek et al., Cancer Res 2011
(Chromosome Aberrations...) :
Here, we show that
BCR/ABL enhances the expression and
increase nuclear localization of
WRN ( mutated in Werner syndrome ), which is required for processing DSB ends during the repair
Clark et al., Mol Immunol 2011
:
However, it has become increasingly apparent that the
BCR also
directs the translocation of MHC class II and
TLR9 into the MIIC and that the endocytic flow of these receptors coincides with that of the BCR ... However, it has become increasingly apparent that the
BCR also
directs the translocation of
MHC class II and TLR9 into the MIIC and that the endocytic flow of these receptors coincides with that of the BCR
Sun et al., Blood 2011
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
WP1130, but not
Bcr-Abl kinase inhibitors, directly
inhibits Usp9x deubiquitinase activity, resulting in the down-regulation of the prosurvival protein Mcl-1 and facilitating apoptosis
Yi et al., BMC biochemistry 2011
:
Transglutaminase 2 (TG2) regulates
Bcr by direct binding to its GAP domain
Allan et al., J Immunol 2011
:
However,
BCR induced upregulation of
CD1c was independent of the RAR pathway
Salas et al., Blood 2011
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2
mediate Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2A ... Sphingosine kinase-1 and
sphingosine 1-phosphate receptor 2 mediate
Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2A ... We show herein that increased
SK-1/S1P enhances
Bcr-Abl1 protein stability, through inhibition of its proteasomal degradation in imatinib-resistant K562/IMA-3 and LAMA-4/IMA human CML cells ... Regulation of
Bcr-Abl1 by SK-1/S1P was
dependent on
S1P receptor 2 (S1P2) signaling, which prevented Bcr-Abl1 dephosphorylation, and degradation via inhibition of PP2A ...
Regulation of
Bcr-Abl1 by
SK-1/S1P was dependent on S1P receptor 2 (S1P2) signaling, which prevented Bcr-Abl1 dephosphorylation, and degradation via inhibition of PP2A ... Since
SK-1/S1P/S1P2 signaling
regulates Bcr-Abl1 stability via modulation of PP2A, inhibition of SK-1/S1P2 axis represents a novel approach to target wild-type- or mutant-Bcr-Abl1 thereby overcoming drug resistance ... Since
SK-1/S1P/S1P2 signaling
regulates Bcr-Abl1 stability via modulation of PP2A, inhibition of SK-1/S1P2 axis represents a novel approach to target wild-type- or mutant-Bcr-Abl1 thereby overcoming drug resistance ... Since
SK-1/S1P/S1P2 signaling
regulates Bcr-Abl1 stability via modulation of PP2A, inhibition of SK-1/S1P2 axis represents a novel approach to target wild-type- or mutant-Bcr-Abl1 thereby overcoming drug resistance
Kometani et al., J Exp Med 2011
:
These mice had impaired T cell independent type II antibody responses in vivo and diminished
IKK-ß activation and cellular
responses to
B cell receptor (BCR) cross linking in vitro
Sheng et al., Blood 2011
(Cell Transformation, Neoplastic...) :
We find that
BCR-ABL , through PI3K/AKT/FOXO4 signaling, transcriptionally up-regulates ATF5 expression and that ATF5, in turn,
stimulates transcription of
mammalian target of rapamycin ( mTOR ; also called mechanistic target of rapamycin ), a well established master negative-regulator of autophagy
Sohn et al., Blood 2011
:
In the present study, we provide evidence that the expression of
FcRL4 in human B-cell lines disrupts immune synapse formation and
blocks antigen induced
BCR signaling at the point of Syk phosphorylation, blocking downstream activation of PLC-?2 and Vav and the induction of calcium responses and CD69 expression
Gross et al., Eur J Immunol 2011
:
The Src-family tyrosine kinase
Lyn negatively
regulates BCR signaling and also myeloid cell activity
Yang et al., J Cell Physiol 2011
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
Promoter deletion and mutation analysis indicate the Tcf-4/ß-catenin and STAT1 binding sites located between the -405/-223 region of the human Jab1 promoter are important for the
activation of
Jab1 by
Bcr-Abl ... Our results also demonstrate that the AKT signaling pathway is involved in the
regulation of
Jab1 by
Bcr-Abl because the AKT inhibitor LY294002 but not the ERK inhibitor PD98059 reduces Jab1 promoter activity and mRNA expression
Chaturvedi et al., Nat Immunol 2011
:
Binding of antigen to the
B cell antigen receptor (BCR) triggers both
BCR signaling and endocytosis
Tabe et al., Leukemia 2012
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
Src related kinase
Lyn is known to interact with CXCL12/CXCR4 signaling and is directly
activated by p210
Bcr-Abl
Singh et al., Cancer 2012
(Blast Crisis...) :
BCR-ABL1 expression
up-regulated HO-1 , a survival factor for CML cells
Yuan et al., Blood 2012
(Cell Transformation, Neoplastic...) :
Activation of stress response gene
SIRT1 by
BCR-ABL promotes leukemogenesis ... In the present study, we show that
BCR-ABL activates the expression of the mammalian stress response gene SIRT1 in hematopoietic progenitor cells and that this
involves STAT5 signaling ... In the present study, we show that
BCR-ABL activates the expression of the mammalian stress response gene
SIRT1 in hematopoietic progenitor cells and that this involves STAT5 signaling ... Imatinib mediated inhibition of
BCR-ABL kinase activity partially
reduces SIRT1 expression and SIRT1 inhibition further sensitizes CML cells to imatinib induced apoptosis
Tschiedel et al., Leukemia & lymphoma 2012
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
Furthermore, the
Bcr-Abl dependent overexpression of
NME2 protein was reversed specifically by tyrosine kinase inhibitor ( TKI ) treatment of Ba/F3 expressing wild-type and TKI-sensitive, but not TKI-resistant, mutants of Bcr-Abl
Colombo et al., PloS one 2012
(Lupus Erythematosus, Systemic...) :
The effect of LAIR1 ligation by specific monoclonal antibodies, collagen or collagen producing mesenchymal stromal cells from reactive lymph nodes or bone marrow on Ig production by pokeweed mitogen and
B cell receptor (BCR) mediated
NF-kB activation was assessed by ELISA and TransAM assay
Pillai et al., Leukemia & lymphoma 2012
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
In parallel,
8-amino-Ado inhibited RNA synthesis and
resulted in a depletion of
BCR-ABL transcript
Katkere et al., J Biol Chem 2012
:
This study establishes that downstream
Syk dependent
BCR signaling is also required for BCR ubiquitination and BCR mediated antigen processing and presentation
Iwata et al., J Allergy Clin Immunol 2012
:
Syk mediated
BCR signaling is a prerequisite for optimal induction of TLR9 and TRAF6, allowing efficient propagation of TLR9 mediated signaling in memory B cells
Kuroda et al., Oncogene 2013
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive...) :
These observations demonstrate that
BCR-ABL is critically
involved in the leukemia-specific expression of
DR4 and DR5 and in the susceptibility of Ph ( + ) leukemia to TRAIL mediated anti-leukemic activity, providing new insight into the mechanisms of the tumor-specific cytotoxic activities of TRAIL
Maruyama et al., J Biol Chem 2012
:
Despite its importance in the TCRs and
BCR activated
TRAF6 inhibition , the involvement of TANK in RANKL signaling is poorly understood
Xu et al., Immunol Cell Biol 2012
:
To understand the mechanisms of PI3K regulation during B-cell activation, we performed a series of biochemical analysis on primary B cells, and found that activity of Src family tyrosine kinases (SFK) is crucial for the
activation of
PI3K following
BCR ligation and this is regulated by the SFK Lyn
Qiu et al., Neoplasia (New York, N.Y.) 2012
(Cell Transformation, Neoplastic...) :
Here, we demonstrate that coexpression of
Bcr-Abl with SOCS-1 or SOCS-3
results in tyrosine phosphorylation of these
SOCS proteins ...
Bcr-Abl dependent tyrosine phosphorylation of
SOCS-1 and SOCS-3 occurs mainly on Tyr 155 and Tyr 204 residues of SOCS-1 and on Tyr 221 residue of SOCS-3 ...
Bcr-Abl dependent tyrosine phosphorylation of SOCS-1 and
SOCS-3 occurs mainly on Tyr 155 and Tyr 204 residues of SOCS-1 and on Tyr 221 residue of SOCS-3
Liu et al., Science signaling 2012
:
Knocking down SAP97 in IgG? B cells or mutating the putative PDZ binding motif in the BCR tail impaired formation of the immunological synapse, initiation of IgG
BCR signaling, and downstream
activation of the mitogen activated protein kinase
p38
Casolari et al., Leukemia 2013
(Blast Crisis...) :
Transient
BCR-ABL expression
led to significant reduction in
BACH2 promoter activity and this effect was dependent on the kinase function of the oncoprotein
Kawano et al., Mol Cell Biol 2012
:
Here we demonstrate that the
pre-BCR signal
induces the expression of lysosome associated protein transmembrane 5 (
LAPTM5 ), which leads to the prompt downmodulation of the pre-BCR
Blix et al., BMC cancer 2012
(Leukemia, Lymphocytic, Chronic, B-Cell...) :
Impaired
anti-BCR induced
p-PLC? was associated with reduced surface expression of IgM and CD79b
Schickel et al., EMBO Mol Med 2012
:
Carabin deficiency in B cells
increases BCR-TLR9 costimulation induced autoimmunity
Raghunandan et al., Scand J Immunol 2013
:
Stimulation through the
BCR results in time dependent inhibition of
Ets-1 mRNA expression in primary splenic B cells with maximal inhibition observed by 16-h post-stimulation
Hsu et al., Immunol Lett 2013
(Arthritis, Rheumatoid...) :
BTK is also an essential
effector of
B cell receptor (BCR) induced B cell signaling
Bergmann et al., J Exp Med 2013
:
B cell survival, surface
BCR and BAFFR expression, CD74 metabolism, and CD8- dendritic cells
require the intramembrane endopeptidase
SPPL2A
Mukherjee et al., Science signaling 2013
:
In contrast, when B cells were stimulated by monomeric ligands that failed to produce BCR clustering, both
Syk and SFKs were
required for complete and rapid
BCR activation
Liu et al., Leuk Res 2013
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
In K562 leukemia cells, overexpression of
miR-30a reduced ABL1 and
BCR-ABL1 protein expression, decreased proliferation, and arrested cell cycle progression between G1 and S
Boukhiar et al., Experimental hematology & oncology 2013
:
BCR engagement
resulted in an increase of
LYN phosphorylation leading to activation of c-JUN NH2-terminal kinase (JNK) and over-expression of the early growth response gene-1 (EGR-1) ... Inhibition of JNK with SP600125 induced apoptosis and reduced level of basal and
BCR induced expression of
EGR-1 ... Treatment with PP2 or with dasatinib suppressed
BCR induced LYN and JNK phosphorylation as well as
EGR-1 upregulation and is associated with a decrease of cell survival in all cases analysed ... Treatment with PP2 or with dasatinib suppressed
BCR induced
LYN and JNK phosphorylation as well as EGR-1 upregulation and is associated with a decrease of cell survival in all cases analysed
Schweighoffer et al., Immunity 2013
:
Surprisingly, BAFFR signaling directly induced phosphorylation of both Syk and the BCR associated Iga signaling subunit, and this
Syk phosphorylation
required the
BCR ... Surprisingly,
BAFFR signaling directly induced phosphorylation of both Syk and the BCR associated Iga signaling subunit, and this Syk phosphorylation
required the
BCR
Harvey et al., BioDrugs 2013
(Lupus Erythematosus, Systemic) :
Epratuzumab is a humanized monoclonal antibody that targets CD22 on B cells and results in modulation of B-cell function and migration, as
CD22 regulates adhesion and
inhibits B-cell receptor (BCR) signalling
Taniguchi et al., PloS one 2013
:
Here, we present data indicating that the increase in intracellular zinc level induced by ZIP9/SLC39A9 ( a ZIP Zrt-/Irt-like protein ) plays an important role in the activation of Akt and
Erk in
response to
BCR activation ... Here, we present data indicating that the increase in intracellular zinc level induced by ZIP9/SLC39A9 ( a ZIP Zrt-/Irt-like protein ) plays an important role in the activation of
Akt and Erk in
response to
BCR activation
Burin et al., Basic Clin Pharmacol Toxicol 2013
:
In this investigation, Bothrops pirajai
L-amino acid oxidase ( BpirLAAO-I )
effect on normal peripheral blood mononuclear cells ( PBMC ) and on
BCR-ABL ( + ) cell line was assessed to explore its potential against leukaemic cells
Xu et al., J Immunol 2013
(Autoimmune Diseases...) :
We further demonstrated that Cd72(c) is a hypofunctional allele in
BCR signal inhibition and that
CD72 deficiency
induces severe autoimmune disease in the presence of Fas ( lpr )
Uhde et al., Int Immunol 2013
:
Neither wild type nor CD83 transgenic (CD83tg) B cells produced any
IL-10 in
response to
BCR stimulation ...
BCR engagement
led to reduced activation of LYN,
SYK and ERK1/2 resulting in reduced numbers of proliferating cells in all CD83tg B cell subsets ...
BCR engagement
led to reduced activation of LYN, SYK and
ERK1/2 resulting in reduced numbers of proliferating cells in all CD83tg B cell subsets ...
BCR engagement
led to reduced activation of
LYN , SYK and ERK1/2 resulting in reduced numbers of proliferating cells in all CD83tg B cell subsets
Liu et al., PloS one 2013
:
A low level of expression of
miR-196b can
cause up-regulation of
BCR-ABL1 and HOXA9 expression, which leads to the development of chronic myeloid leukemia
Day et al., Endocrinology 1988
(Pituitary Neoplasms) :
Both
TRH- and vasoactive intestinal peptide stimulated PRL release were
inhibited to basal levels by 10 nM
BCR , with an IC50 for BCR of approximately 0.25 nM ... Both TRH- and vasoactive intestinal peptide stimulated
PRL release were
inhibited to basal levels by 10 nM
BCR , with an IC50 for BCR of approximately 0.25 nM
Notter et al., J Anim Sci 1988
:
Effects of
CRG on
BCR and CD were small at high values of CRG, but these effects increased as CRG declined
Elson et al., Immunology 1981
:
This
Igb anti-Iga response was profoundly
suppressed by injecting lymphoid cells from congenic Iga mice but not by serum
Iga
Maru et al., Mol Cell Biol 1995
(Cell Transformation, Neoplastic) :
Tyrosine phosphorylation of BCR by FPS/FES protein-tyrosine kinases
induces association of
BCR with
GRB-2/SOS ... Tyrosine phosphorylation of BCR by FPS/FES protein-tyrosine kinases
induces association of
BCR with
GRB-2/SOS ... Coexpression of
BCR with the cytoplasmic protein-tyrosine kinase encoded by the c-fes proto-oncogene in Sf-9 cells
resulted in stable
BCR-FES protein complex formation and tyrosine phosphorylation of BCR ... Tyrosine phosphorylation of
BCR in v-fps transformed cells
induced its association with
GRB-2/SOS , the RAS guanine nucleotide exchange factor complex ... Tyrosine phosphorylation of
BCR in v-fps transformed cells
induced its association with
GRB-2/SOS , the RAS guanine nucleotide exchange factor complex
Harrison-Findik et al., Oncogene 1995
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
P210
BCR/abl tyrosine kinase
induces tyrosine phosphorylation of
Shc , and activation of p21ras and PI 3-Kinase ... P210
BCR/abl tyrosine kinase
induces tyrosine phosphorylation of Shc, and activation of
p21ras and PI 3-Kinase ... P210
BCR/abl tyrosine kinase
induces tyrosine phosphorylation of Shc, and activation of p21ras and
PI 3-Kinase
Takata et al., FEBS Lett 1995
:
These results demonstrate that the
BCR induced phosphorylation of
Src-PTK is independent of Syk and that the kinase activity of Src-PTK is critical for BCR signaling ... These results demonstrate that the
BCR induced phosphorylation of
Src-PTK is independent of Syk and that the kinase activity of Src-PTK is critical for BCR signaling
Skorski et al., Blood 1995
(Blast Crisis...) :
Phosphatidylinositol-3 kinase activity is
regulated by
BCR/ABL and is required for the growth of Philadelphia chromosome positive cells
Hata et al., Mol Cell Biol 1994
:
To investigate the
role of
Csk in
BCR signaling, Csk negative chicken B-cell clones were generated
Ernst et al., J Biol Chem 1994
:
p210Bcr/Abl and p160v-Abl
induce an increase in the tyrosine phosphorylation of
p93c-Fes
Galibert et al., J Exp Med 1996
:
CD40 +
BCR stimulation of resting B cells with CD40 ligand transfected fibroblastic cells in the presence of cross linked anti-BCR monoclonal antibodies
resulted in the coexpression of CD38,
CD95 , and CPM ... CD40 +
BCR stimulation of resting B cells with CD40 ligand transfected fibroblastic cells in the presence of cross linked anti-BCR monoclonal antibodies
resulted in the coexpression of
CD38 , CD95, and CPM ... CD40 +
BCR stimulation of resting B cells with CD40 ligand transfected fibroblastic cells in the presence of cross linked anti-BCR monoclonal antibodies
resulted in the coexpression of CD38, CD95, and
CPM
Luisiri et al., J Biol Chem 1996
:
The
enhancement of
Ig-alpha phosphorylation by
Ig-beta correlated with a lowering of the stimulation threshold for tyrosine kinase activation
Maltzman et al., Mol Cell Biol 1996
(Lymphoma, B-Cell) :
BCR induced increases in
CD44 mRNA expression and transcription levels are shown to occur in EGR1 expressing but not in nonexpressing subclones of the B-cell line WEHI-231
Kawauchi et al., Mol Immunol 1996
:
Ligation of the
B cell Ag receptor (BCR) activates a
protein-tyrosine kinase ( PTK ) and CD45 protein-tyrosine phosphatase ( PTPase ) -dependent signaling cascade that results in the activation of Ras
Maltzman et al., J Exp Med 1996
:
ICAM-1 expression is upregulated as a
consequence of
B lymphocyte antigen receptor (BCR) signaling, thereby serving to render antigen stimulated B cells more receptive to T cell mediated costimulatory signals ... We have investigated
BCR induced expression of the
Icam-1 gene in primary B cells and B cell lines and have found it to be dependent on BCR induced expression of the transcription factor EGR1
Neumann et al., Anticancer Res 1996
(Leukemia, Megakaryoblastic, Acute) :
A human myeloid cell line, Mo7, and a daughter cell line expressing the bcr/abl oncogene, Mo7-P210, were used in a comparative study analyzing the
effects of
p210BCR/ABL expression on tyrosine phosphorylation, specific DNA binding and expression of the proto-oncoprotein
c-Rel
Smit et al., Oncogene 1996
(Burkitt Lymphoma) :
B-cell antigen receptor (BCR) stimulation
induces tyrosine phosphorylation of the
Shc adaptor protein and its association with Grb2 ...
B-cell antigen receptor (BCR) stimulation
induces tyrosine phosphorylation of the Shc adaptor protein and its association with
Grb2 ... We reveal here an additional complexity of the
BCR induced
Shc/Grb2 complex : it contains tyrosine phosphorylated proteins of 130, 110 and 75 kDa
Lund et al., J Immunol 1996
(Lymphoma, B-Cell) :
Together, these data demonstrate that the CD38 molecule can influence BCR induced responses and that
CD38 signaling is
dependent on the
BCR complex , perhaps to utilize a functional cytoplasmic tail ( s ) for intracellular signaling
Jain et al., Blood 1996
:
PI 3-kinase activation in BCR/abl transformed hematopoietic cells does not
require interaction of p85 SH2 domains with p210
BCR/abl ... Despite lack of direct interaction with p85 SH2 domains, expression of ts p210 BCR/abl resulted in rapid, time dependent activation of total and membrane associated PI 3-kinase and increased PI 3-kinase activity in anti-P-tyr and anti-abl immunoprecipitates ... These data suggest that BCR/abl induced activation of PI 3-kinase in hematopoietic cells does not require binding of p85 SH2 domains to BCR/abl gene product and involves interaction with other tyrosine phosphorylated intermediate proteins
Salgia et al., J Biol Chem 1996
(Cell Transformation, Neoplastic) :
In both normal and BCR/ABL transformed cells, p130 ( CAS ) was detected in focal adhesion-like structures, as was BCR/ABL
Sutherland et al., J Immunol 1996
:
We found that BCR engagement in WEHI-231 cells caused a 15- to 20-fold activation of ERK2 and a 2- to 3-fold stimulation of ERK1 ... In summary, the BCR strongly activates ERK2 and weakly activates ERK1, JNK, and p38 , while CD40 markedly stimulates the JNK and p38 kinases ... In summary, the BCR strongly activates ERK2 and weakly activates ERK1 , JNK, and p38, while CD40 markedly stimulates the JNK and p38 kinases
Ingham et al., J Biol Chem 1996
:
We show that engaging the
B cell antigen receptor (BCR) on the RAMOS B cell line
caused both Crk-L and
Crk II to associate with several tyrosine phosphorylated proteins ... We show that engaging the
B cell antigen receptor (BCR) on the RAMOS B cell line
caused both
Crk-L and Crk II to associate with several tyrosine phosphorylated proteins
Einat et al., Leuk Res 1996
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
A decrease in
BCR/ABL fusion product was observed ( by FISH analysis ) after incubation of BM cells from CML patients in liquid culture for 7 days with 10 ( -9 ) M ARA-C or 10 ( -7 ) M Eilatin in the
presence of
IL-11 alone or in combination with other cytokines
Li et al., J Biol Chem 1996
:
Mutagenesis of BCR Tyr-177 to Phe completely abolished
FES induced
BCR binding to the GRB2 SH2 domain, identifying Tyr-177 as an additional phosphorylation site for FES ... By contrast, tyrosine phosphorylation of
BCR by FES
suppressed BCR
serine/threonine kinase activity toward the 14-3-3 protein and BCR substrate, BAP-1
Rozsnyay et al., Immunol Lett 1996
:
Here we studied the potential
involvement of
ezrin in the
B-cell receptor (BCR) signaling in BL41 Burkitt lymphoma cells
Pao et al., J Immunol 1997
:
CD45 expression is
required for
BCR triggering of certain of these downstream events, such as calcium mobilization and p21ras activation
Wang et al., J Exp Med 1996
:
Compared with control B cells, Lyn-/- B cells were hyper responsive to anti-IgM induced proliferation and defective in
Fc gamma RIIB mediated suppression of
B cell antigen receptor (BCR) signaling, indicating that Lyn is involved in the negative regulation of BCR signaling ... Compared with control B cells, Lyn-/- B cells were hyper responsive to anti-IgM induced proliferation and defective in Fc gamma RIIB mediated suppression of B cell antigen receptor (BCR) signaling, indicating that
Lyn is
involved in the negative regulation of
BCR signaling ... Moreover,
BCR cross linking in Lyn-/- B cells
suppressed Fas expression induced by costimulation with CD40 ligand and IL-4
Sánchez-García et al., J Mol Biol 1997
(Cell Transformation, Neoplastic...) :
Regulation of
Bcl-2 gene expression by
BCR-ABL is mediated by Ras
Harmer et al., Mol Cell Biol 1997
:
Cross linking of the
B-cell antigen receptor (BCR) induces tyrosine phosphorylation of
Shc , which is believed to lead to the activation of Ras
Wilson-Rawls et al., Leukemia 1997
:
P210
Bcr-Abl interacts with the interleukin-3 beta c subunit and constitutively
activates Jak2
Li et al., J Biol Chem 1997
:
Syk is required for
BCR mediated
activation of
p90Rsk , but not p70S6k, via a mitogen activated protein kinase independent pathway in B cells ... Syk is required for
BCR mediated activation of p90Rsk, but not
p70S6k , via a mitogen activated protein kinase independent pathway in B cells
Vuica et al., J Exp Med 1997
:
The differential
effects of
BCR and BCR-FcgammaRIIB1 mediated signaling on the phosphorylation of
GAP-A.p62 and its association with Csk suggest that docking of Csk to GAP-A.p62 may function in the negative regulation of antigen receptor mediated signals in B cells
Chan et al., Immunity 1997
:
Lyn-deficient mice were generated to analyze the
role of
Lyn in
B cell antigen receptor (BCR) signaling
Haataja et al., J Biol Chem 1997
:
Rac3 is an active GTPase, and this activity is
regulated by
Bcr
McWhirter et al., Oncogene 1997
(Cell Transformation, Neoplastic) :
Previous studies have demonstrated that both the
Bcr and the Abl functional domains
contribute to the oncogenic activity of
Bcr-Abl proteins ... Previous studies have demonstrated that both the
Bcr and the Abl functional domains
contribute to the oncogenic activity of
Bcr-Abl proteins
Sato et al., Proc Natl Acad Sci U S A 1997
:
Ligation of
CD19 and CD22 in vivo is likely to positively and negatively
regulate BCR signaling, respectively, because CD19 crosslinking was more efficient than BCR crosslinking at inducing Vav phosphorylation ... Ligation of CD19 and
CD22 in vivo is likely to positively and negatively
regulate BCR signaling, respectively, because CD19 crosslinking was more efficient than BCR crosslinking at inducing Vav phosphorylation
Hamdane et al., Oncogene 1997
:
Activation of p65 NF-kappaB protein by p210BCR-ABL in a myeloid cell line (
P210BCR-ABL activates p65
NF-kappaB ) ... We have analysed the
effect of
p210BCR-ABL expression on
NF-kappaB activity in DA1 cells ( an IL-3 dependent murine myeloid progenitor cell line ) ... A specific
stimulation of
NF-kappaB activity by kinase-active wild-type
p210BCR-ABL has been evidenced by transcriptional activation assays
Warmuth et al., J Biol Chem 1997
:
Neither the complex formation of Hck kinase with Bcr-Abl nor the
activation of
Hck by
Bcr-Abl was dependent on the Abl kinase activity ... Neither the complex formation of Hck kinase with Bcr-Abl nor the activation of Hck by
Bcr-Abl was
dependent on the
Abl kinase activity
Genevier et al., Clin Exp Immunol 1997
(Agammaglobulinemia) :
Impaired
Ca2+ mobilization by X-linked agammaglobulinaemia ( XLA ) B cells in
response to ligation of the
B cell receptor (BCR)
Kitanaka et al., Blood 1998
(Agammaglobulinemia) :
In surface immunoglobulin positive B cells ( Ramos ), ligation of the
B-cell antigen receptor (BCR) with anti-IgM antibodies caused marked tyrosine phosphorylation of Tec and
increased Tec tyrosine kinase activity
Ahmed et al., Oncogene 1998
:
Our results indicate that although both constitutively activated cEpoR and BCR-ABL oncogenes induce growth-factor independence in Ba/F3 cells, only
BCR-ABL is able to protect cells from etoposide and serum-deprivation induced apoptosis and
induce a strong constitutive activation of
STAT factors, suggesting a role for these molecules in the anti-apoptotic activity of BCR-ABL
Salmon et al., J Immunol 1997
:
We conclude that the
activation of p38
MAPK and MAPKAP kinase-2 by cross linking of the TCR,
BCR , Fas, or CD40 was not correlated with their roles in regulating lymphocyte survival, and that suppression of kinase activity did not inhibit the induction of apoptosis ... We conclude that the
activation of p38 MAPK and
MAPKAP kinase-2 by cross linking of the TCR,
BCR , Fas, or CD40 was not correlated with their roles in regulating lymphocyte survival, and that suppression of kinase activity did not inhibit the induction of apoptosis
Cornall et al., Immunity 1998
(Lupus Erythematosus, Systemic) :
Lyn is not
required to initiate
B cell antigen receptor (BCR) signaling but is an essential inhibitory component
Bolland et al., Immunity 1998
:
Conversely,
increasing PIP3 levels by deletion of SHIP results in increased Btk association with the membrane and hyperresponsive
BCR signaling
Adachi et al., J Immunol 1998
:
Moreover, cross linking of
B cell Ag receptor (BCR) enhances both tyrosine phosphorylation of CD72 and association of
CD72 with SHP-1 in B cell line WEHI-231
Chan et al., Curr Biol 1998
:
To elucidate the
role of the Src family kinase
Lyn in
B cell receptor (BCR) signaling, we and others previously generated lyn-/- mice and analyzed their B cell responses ... Although the initiation of
BCR signaling in lyn-/- B cells is delayed, BCR induced
ERK2 activation and proliferation are
enhanced
Dennehy et al., Eur J Immunol 1998
:
Both c-cbl and ras GAP have been proposed to suppress receptor mediated signaling, and may contribute to
CD5 mediated suppression of TCR or
BCR signaling
Lens et al., J Immunol 1998
:
Indeed, ligation of both Fas and
BCR resulted in cleavage of the IL-1beta converting enzyme/Ced-3-like protease
caspase 3 and its substrates Ac-Asp-Glu-Val-Asp-aldehyde and poly ( ADP-ribose ) polymerase
Graves et al., J Immunol 1998
(Lymphoma, B-Cell) :
Both
BCR- and Fas induced apoptosis are
blocked by the peptide cysteine protease inhibitor
benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone ( ZVAD ( mlz ) ), demonstrating a common requirement caspase activity ... To determine the
role of
p38 MAPK activation in
BCR- and Fas induced apoptosis, we employed SB203580, a specific inhibitor of p38 MAPK ... To determine the
role of p38
MAPK activation in
BCR- and Fas induced apoptosis, we employed SB203580, a specific inhibitor of p38 MAPK
Selleri et al., Blood 1998
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive...) :
Fas mediated modulation of
Bcr/Abl in chronic myelogenous leukemia results in differential effects on apoptosis
Reiter et al., Blood 1998
(Myeloproliferative Disorders...) :
We hypothesize that this fusion leads to constitutive activation of the FGFR1 tyrosine kinase in a manner analogous to the
activation of
ABL by
BCR in chronic myeloid leukemia
Skorski et al., Proc Natl Acad Sci U S A 1998
(Leukemia, Experimental...) :
We show here that the small GTP binding protein
Rac is
activated by
BCR/ABL in a tyrosine kinase dependent manner
Hashimoto et al., J Exp Med 1998
:
Here we demonstrate that the
BCR induced
ERK activation is reduced by loss of Grb2 or expression of a dominant negative form of Ras, RasN17, whereas this response is not affected by loss of Shc ... Similar to cooperation of Ras with PKC activation in ERK response, both PLC-gamma2 dependent signal and GTPase are required for
BCR induced JNK and
p38 responses
Jiang et al., J Exp Med 1998
:
BCR cross linking in the chicken DT40 B cell line also
activates three distinct mitogen activated protein kinases ( MAPKs ) : extracellular signal regulated kinase ( ERK ) 2, c-jun NH2-terminal kinase ( JNK ) 1, and p38
MAPK ... BCR mediated activation of ERK2, although maintained in Lyn-deficient cells, was abolished in Syk-deficient cells and partially inhibited in Btk-deficient cells, indicating that
BCR mediated ERK2 activation requires Syk and that sustained ERK2 activation
requires Btk ... BCR mediated activation of ERK2, although maintained in Lyn-deficient cells, was abolished in Syk-deficient cells and partially inhibited in Btk-deficient cells, indicating that
BCR mediated ERK2 activation
requires Syk and that sustained ERK2 activation requires Btk ... BCR mediated activation of ERK2, although maintained in Lyn-deficient cells, was abolished in Syk-deficient cells and partially inhibited in Btk-deficient cells, indicating that
BCR mediated ERK2 activation requires Syk and that sustained
ERK2 activation
requires Btk ... However,
BCR mediated
p38 MAPK activation was abolished in Lyn/Syk double deficient cells, demonstrating that either Lyn or Syk alone may be sufficient to activate p38 MAPK ... However,
BCR mediated p38
MAPK activation was abolished in Lyn/Syk double deficient cells, demonstrating that either Lyn or Syk alone may be sufficient to activate p38 MAPK
McLeod et al., J Biol Chem 1998
:
In this report, we show that
BCR engagement
activates Rap1 and that this is dependent on production of diacylglycerol ( DAG ) by phospholipase C-gamma ... However, the DAG dependent pathway by which the
BCR activates
Rap1 apparently does not involve Crk signaling complexes since phorbol dibutyrate could activate Rap1 without inducing the formation of these complexes ... Thus, the
BCR activates
Rap1 via a novel DAG dependent pathway
Zhang et al., Blood 1998
(Cell Transformation, Neoplastic...) :
Bcr-Abl efficiently
induces a myeloproliferative disease and production of excess interleukin-3 and granulocyte-macrophage
colony stimulating factor in mice : a novel model for chronic myelogenous leukemia ...
Bcr-Abl efficiently
induces a myeloproliferative disease and production of excess
interleukin-3 and granulocyte-macrophage colony stimulating factor in mice : a novel model for chronic myelogenous leukemia
Mullins et al., Mol Immunol 1998
:
Finally,
CD40 mediated signals
induce resting B cells to accumulate the CKI, p21, while cycling B cells require both
BCR- and CD40 mediated signals to maintain increased expression of p21
Zhang et al., EMBO J 1998
:
By monitoring the activation of signaling elements in pervanadate stimulated B cells expressing different levels of the BCR, we show here that phosphorylation of SLP-65 and
Syk , but not of Lyn, is strictly
dependent on the expression of the
BCR on the cell surface ... By monitoring the activation of signaling elements in pervanadate stimulated B cells expressing different levels of the BCR, we show here that phosphorylation of
SLP-65 and Syk, but not of Lyn, is strictly
dependent on the expression of the
BCR on the cell surface
Venkataraman et al., Mol Immunol 1998
:
Previous studies have shown that PKA-activation blocks
BCR induced
phospholipase Cgamma-activation and calcium mobilization
Shi et al., Blood 1999
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
Either an oncogenic form of Ras or
Bcr-Abl enhances
GCKR catalytic activity and its activation of SAPK, whereas inhibition of GCKR impairs Bcr-Abl induced SAPK activation