Gene interactions and pathways from curated databases and text-mining

◀ Back to CD79A

CD79A — CD79B

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Sei et al., J Biol Chem 1999 (Calcium Signaling) : Furthermore, BCR mediated Ca2+ release in CD19 ( + ) B cells was significantly altered by 4-chloro-m-cresol and ryanodine ... These results indicate that RYR1 functions as a Ca2+ release channel during BCR stimulated Ca2+ signaling and suggest that complex Ca2+ signals that control the cellular activities of B cells may be generated by cooperation of the IP3 receptor and RYR1
Wagle et al., J Immunol 1999 : Here we investigate the influence of the FcgammaRIIB1 on BCR mediated Ag processing and show that coligating the FcgammaRIIB1 and the BCR negatively regulates both BCR signaling for enhanced Ag processing and BCR mediated Ag internalization
Hitomi et al., FEBS Lett 1999 : Herein we provide biochemical and genetic evidence that cross linking of the B cell receptor (BCR) induces rapid activation of PLD through a Syk-, Btk- and phospholipase C (PLC)-gamma2 dependent pathway in DT40 cells ... These results demonstrate that Syk, Btk and PLC-gamma2 are essential for BCR induced PLD activation
Buhl et al., J Immunol 1999 (Calcium Signaling...) : Bruton's tyrosine kinase (Btk) plays a critical role in B cell Ag receptor (BCR) signaling, as indicated by the X-linked immunodeficiency and X-linked agammaglobulinemia phenotypes of mice and men that express mutant forms of the kinase
Krzysiek et al., J Immunol 1999 : We show herein that B cell Ag receptor (BCR) triggering, but not stimulation by CD40 mAb and/or IL-4 , rapidly induced the coordinated expression of two closely related T cell chemoattractants, macrophage inflammatory protein-1 beta ( MIP-1 beta ) and MIP-1 alpha, by human B cells
Harmer et al., J Biol Chem 1999 : Here, we report that cross linking of the BCR induces association between Grb2 and SHIP as well as association between Shc and SHIP ... Here, we report that cross linking of the BCR induces association between Grb2 and SHIP as well as association between Shc and SHIP
Nieborowska-Skorska et al., J Exp Med 1999 (Leukemia) : Together, these data demonstrate that STAT5 activation by BCR/ABL is dependent on signaling from more than one domain and document the important role of STAT5 regulated pathways in BCR/ABL leukemogenesis
Maeda et al., Oncogene 1999 (Calcium Signaling) : Paired immunoglobulin-like receptor B ( PIR-B ) inhibits BCR induced activation of Syk and Btk by SHP-1 ... Paired immunoglobulin-like receptor B ( PIR-B ) inhibits BCR induced activation of Syk and Btk by SHP-1
Li et al., Proc Natl Acad Sci U S A 1999 : In this study, we demonstrate that ligation of B cell antigen receptor (BCR) leads to activation of Akt/PKB in B lymphocytes ... In this study, we demonstrate that ligation of B cell antigen receptor (BCR) leads to activation of Akt/PKB in B lymphocytes ... BCR induced activation of Akt/PKB required the tyrosine kinase Syk , which was not previously known to regulate Akt/PKB ... BCR induced activation of Akt/PKB required the tyrosine kinase Syk, which was not previously known to regulate Akt/PKB ... BCR induced activation of Akt/PKB required the tyrosine kinase Syk, which was not previously known to regulate Akt/PKB ... Our results show that Lyn provides a mechanism for negative regulation and opposes the effect of Syk on BCR mediated activation of Akt/PKB ... Our results show that Lyn provides a mechanism for negative regulation and opposes the effect of Syk on BCR mediated activation of Akt/PKB
Astoul et al., J Cell Biol 1999 : Membrane translocation of PKB and subsequent PKB activation are dependent on BCR activation of phosphatidylinositol 3-kinase (PI3K) ... Membrane translocation of PKB and subsequent PKB activation are dependent on BCR activation of phosphatidylinositol 3-kinase (PI3K) ... Membrane translocation of PKB and subsequent PKB activation are dependent on BCR activation of phosphatidylinositol 3-kinase (PI3K)
Gold et al., J Immunol 1999 : We have previously shown that the B cell Ag receptor (BCR) activates phosphatidylinositol (PI) 3-kinase
Tanguay et al., J Immunol 1999 : These results suggest that assembly or stabilization of D-type cyclin holoenzyme complexes 1 ) is an important step in the activation of Cdk4/6 by BCR signals, and 2 ) suffice in providing a mechanism to account for inhibition of BCR stimulated Rb protein phosphorylation by Fc gamma R ... These results suggest that assembly or stabilization of D-type cyclin holoenzyme complexes 1 ) is an important step in the activation of Cdk4/6 by BCR signals, and 2 ) suffice in providing a mechanism to account for inhibition of BCR stimulated Rb protein phosphorylation by Fc gamma R
Gross et al., Mol Cell Biol 1999 (Cell Transformation, Neoplastic...) : We have recently shown that expression of Bcr-Abl in bone marrow cells by retroviral transduction efficiently induces in mice a myeloproliferative disease resembling human CML and that Abl kinase activity is essential for Bcr-Abl to induce a CML-like myeloproliferative disease
Craxton et al., J Biol Chem 1999 : Increased BCR induced Akt phosphorylation was observed in Lyn-deficient DT40 cells and Lyn ( -/- ) mice compared with wild-type cells suggesting that Lyn may negatively regulate Akt function
Su et al., J Biol Chem 1999 : Finally, we show that co-ligation of CD19 with the BCR results in increased tyrosine phosphorylation of STAT1 relative to BCR cross linking alone, establishing CD19 as a positive modulator of BCR mediated STAT activation
Yankee et al., J Immunol 1999 : These studies indicate that c-Cbl may contribute to the regulation of BCR signaling by modulating the ability of Syk to associate with the BCR and couple the receptor to intracellular signaling pathways
Ingham et al., J Immunol 1999 : Tyrosine phosphorylation of Shc in response to B cell Ag receptor (BCR) engagement creates binding sites for the Src homology 2 (SH2) domain of Grb2 ... BCR induced tyrosine phosphorylation of Shc could be restored in the these cells by expressing wild-type SHIP but not by expressing a mutant form of SHIP that can not bind to Shc
Adachi et al., J Immunol 2000 (Calcium Signaling...) : In this paper we demonstrate that expression of CD72 down-modulates both extracellular signal related kinase ( ERK ) activation and Ca2+ mobilization induced by BCR ligation in the mouse B lymphoma line K46micromlambda, whereas BCR mediated ERK activation was not reduced by the ITIM mutated form of CD72
Wei et al., J Immunol 2000 : Consequently, up-regulation of TdT and IL-7R alpha expression requires signaling through the high affinity IL-7R, but does not require cmu expression or a functional pre-BCR
Rhodes et al., Exp Hematol 2000 : Additionally, in the presence of Bcr-Abl , CrkL is found in the nucleus, can be detected in a Stat5/DNA complex, and increases transcriptional activation from a Stat-responsive reporter construct
Horita et al., J Exp Med 2000 (Blast Crisis...) : Here, we show that the interleukin 3-independent expression of the antiapoptotic protein, Bcl-xL , is induced by Bcr-Abl through activation of signal transducer and activator of transcription ( Stat ) 5 ... Here, we show that the interleukin 3-independent expression of the antiapoptotic protein, Bcl-xL, is induced by Bcr-Abl through activation of signal transducer and activator of transcription ( Stat ) 5
Tamir et al., Immunity 2000 : This function is reportedly mediated in part by inhibition of B cell antigen receptor (BCR) mediated p21ras activation, though the basis of this inhibition is unknown
Voss et al., Oncogene 2000 (MAP Kinase Signaling System...) : The mitogenic MAPK/Erk kinases as well as Akt/PKB , a kinase implicated to negatively regulate apoptosis, were also constitutively activated by both Bcr-Abl and Tel-Abl ... The mitogenic MAPK/Erk kinases as well as Akt/PKB , a kinase implicated to negatively regulate apoptosis, were also constitutively activated by both Bcr-Abl and Tel-Abl
Dunant et al., Cell Signal 2000 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : Expression of Bcr-Abl induced tyrosine phosphorylation of both Dok1 and SHIP1 and the formation of a Dok1/SHIP1 complex ... Expression of Bcr-Abl induced tyrosine phosphorylation of both Dok1 and SHIP1 and the formation of a Dok1/SHIP1 complex
Lionberger et al., J Biol Chem 2000 (Leukemia, Myeloid) : Recent work shows that Hck , a member of the Src tyrosine kinase family with myeloid restricted expression, associates with and is activated by Bcr-Abl
Puccetti et al., Cancer Res 2000 (Blast Crisis...) : Here, we report that : ( a ) As2O3 induced apoptosis in Ph+ but not in Ph- lymphoblasts ; ( b ) enforced expression of BCR-ABL in U937 cells dramatically increased the sensitivity to As2O3 ; ( c ) the effect of As2O3 was independent of BCR-ABL kinase activity ; and ( d ) As2O3 reduced proliferation of chronic myelogenous leukemia blasts but not of peripheral CD34+ progenitors
Perrotti et al., Mol Cell Biol 2000 : The DNA binding activity of FUS ( also known as TLS ), a nuclear pro-oncogene involved in multiple translocations, is regulated by BCR-ABL in a protein kinase CbetaII ( PKCbetaII ) -dependent manner ... FUS proteolysis is induced by c-Jun , is suppressed by BCR-ABL or Jun kinase 1, and does not depend on c-Jun transactivation potential, ubiquitination, or its interaction with Jun kinase 1 ... FUS proteolysis is induced by c-Jun, is suppressed by BCR-ABL or Jun kinase 1, and does not depend on c-Jun transactivation potential, ubiquitination, or its interaction with Jun kinase 1
Gesbert et al., J Biol Chem 2000 : We demonstrate that the decrease of p27 ( Kip1 ) is directly due to BCR/ABL in hematopoietic cells by two different approaches ... The PI3K inhibitor LY-294002 blocks the ability of BCR/ABL to induce p27 ( Kip1 ) down-regulation and inhibits BCR/ABL induced entry into S phase ... Overall, these data are consistent with a model in which BCR/ABL suppresses p27 ( Kip1 ) protein levels through PI3K/AKT, leading to accelerated entry into S phase
Swart et al., Biochem Biophys Res Commun 2000 : We have recently demonstrated that BCR cross linking leads to a transient activation of p38 mitogen activated protein kinase ( MAPK ) in CH31 B cells
Otero et al., J Biol Chem 2001 (Lymphoma, B-Cell) : A prominent feature of CD19 signaling is the binding and activation of phosphoinositide 3-kinase ( P13K ), which accounts for the majority of PI3K activity induced by BCR ligation
Petro et al., J Biol Chem 2001 : Specifically, pharmacologic agents that block the action of either PLC-gamma2 or its second messengers prevent BCR induced activation of IkappaB kinase ... Moreover, activation of NF-kappaB in response to BCR signaling is completely abolished in B cells deficient for PLC-gamma2
Gold et al., Immunol Rev 2000 : In this review, we discuss the role of phosphatidylinositol 3-kinase (PI3K) and Rap 1 in B-cell receptor (BCR) signaling ... In this review, we discuss the role of phosphatidylinositol 3-kinase (PI3K) and Rap 1 in B-cell receptor (BCR) signaling ... We showed that the BCR activates Rap1 via phospholipase C-dependent production of diacylglycerol
Doody et al., EMBO J 2000 : The CD19 co-receptor physically interacts with Vav-2 and synergistically enhances Vav-2 phosphorylation induced by the B-cell receptor (BCR)
Dykstra et al., Immunity 2001 : Here, we show that LMP2A resides in lipid rafts and excludes the BCR from entering rafts by Lyndependent mechanisms, thus blocking both BCR signaling and antigen transport
Ogimoto et al., FEBS Lett 2001 (MAP Kinase Signaling System) : We found that CD45 negatively regulated BCR induced c-Jun NH ( 2 ) -terminal kinase ( JNK ) and p38 activation in immature WEHI-231 cells, whereas in mature BAL-17 cells, CD45 positively regulated JNK and p38 activation and negatively regulated extracellular signal regulated kinase activity
Baba et al., Proc Natl Acad Sci U S A 2001 : The existence of such an activation mechanism is supported by the observation that the BCR induced Btk phosphorylation and activation are significantly reduced in BLNK-deficient B cells as well as in Syk-deficient B cells
Cheng et al., J Immunol 2001 : Translocation of the BCR into lipid rafts did not require the Ig alpha/Ig beta signaling complex, was not dependent on engagement of the FcR, and was not blocked by the Src family kinase inhibitor PP2 or the actin depolymerizing agents cytochalasin D or latrunculin ... Translocation of the BCR into lipid rafts did not require the Ig alpha/Ig beta signaling complex, was not dependent on engagement of the FcR, and was not blocked by the Src family kinase inhibitor PP2 or the actin depolymerizing agents cytochalasin D or latrunculin
Richards et al., J Immunol 2001 (MAP Kinase Signaling System) : PD98059 or U0126 treatment substantially inhibited the BCR induced activation of the extracellular signal regulated kinase ( ERK ) forms of mitogen activated protein kinase in the immature B cell line WEHI-231, in immature splenic B cells, and in mature splenic B cells
Ingham et al., J Biol Chem 2001 : Gab1 expression also increased BCR induced tyrosine phosphorylation of SHP2 as well as the binding of Grb2 to SHP2 ... Gab1 expression also increased BCR induced tyrosine phosphorylation of SHP2 as well as the binding of Grb2 to SHP2 ... We show that the pleckstrin homology (PH) domain of Gab1 is required for BCR induced phosphorylation of Gab1 and for Gab1 participation in BCR signaling ... We show that the pleckstrin homology (PH) domain of Gab1 is required for BCR induced phosphorylation of Gab1 and for Gab1 participation in BCR signaling ... Moreover, using confocal microscopy, we show that BCR ligation can induce the translocation of Gab1 from the cytosol to the plasma membrane and that this requires the Gab1 PH domain as well as PI3K activity ... Moreover, using confocal microscopy, we show that BCR ligation can induce the translocation of Gab1 from the cytosol to the plasma membrane and that this requires the Gab1 PH domain as well as PI3K activity
Nitta et al., Exp Cell Res 2001 : Furthermore, addition of spermine could repress the BCR mediated apoptosis by attenuating the mitochondrial membrane potential ( Deltapsim ) loss and activation of caspase-7 induced by BCR signaling
Tian et al., Int Immunol 2001 : For BCR induced apoptosis, we provide evidence that the final apoptotic destruction phase can be inhibited by the pan-caspase inhibitor BOC-Asp-FMK ( BD ) and that, in the presence of BD, the BCR only induces growth arrest which is reversible ... For BCR induced apoptosis, we provide evidence that the final apoptotic destruction phase can be inhibited by the pan-caspase inhibitor BOC-Asp-FMK ( BD ) and that, in the presence of BD, the BCR only induces growth arrest which is reversible
Lin et al., Oncogene 2001 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : Induction of exogenous Bcr protein by removal of Tet from the culture medium caused a dramatic increase in Bcr serine kinase activity, yielding predominantly phosphoserine Bcr, despite the presence of Bcr-Abl in the kinase reaction mixture
Fukada et al., J Biol Chem 2001 : Previously, we have shown that the expression of PTP1B is enhanced by p210 Bcr-Abl and that PTP1B is a specific antagonist of transformation induced by this oncoprotein protein-tyrosine kinase ... The binding of Egr-1 to PRS is suppressed by p210 Bcr-Abl due to the inhibition of Egr-1 expression, resulting in the enhancement of PTP1B promoter activity ... The binding of Egr-1 to PRS is suppressed by p210 Bcr-Abl due to the inhibition of Egr-1 expression, resulting in the enhancement of PTP1B promoter activity
Bone et al., Int Immunol 2001 : Nuclear NF-kappaB is induced in B cells by engagement of either the BCR or CD40 or by stimulation with lipopolysaccharide (LPS) ... Nuclear NF-kappaB is induced in B cells by engagement of either the BCR or CD40 or by stimulation with lipopolysaccharide (LPS) ... Interestingly, a PKC inhibitor which blocked the BCR induced IkappaBalpha degradation had no effect on the degradation of IkappaBalpha after LPS stimulation
Natarajan et al., J Immunol 2001 (Second Messenger Systems) : Whereas B cell Ag receptor (BCR) cross linking alone stimulated increased expression of CD86 , up-regulation of CD80 required dual stimulation with anti-IgM and anti-CD54
Wu et al., J Immunol 2001 (Severe Combined Immunodeficiency) : Although both CD72 and BCR induced Btk dependent ERK activation, CD72 mediated proliferation is more resistant to blocking of ERK activity than that of BCR, as shown by the proliferation response of B cells treated with PD98059 and dibutyryl cAMP, agents that inhibit ERK activity ... Although both CD72 and BCR induced Btk dependent ERK activation, CD72 mediated proliferation is more resistant to blocking of ERK activity than that of BCR, as shown by the proliferation response of B cells treated with PD98059 and dibutyryl cAMP, agents that inhibit ERK activity
Watanabe et al., J Biol Chem 2001 : Substitution of all four tyrosine residues almost completely eliminated the BCR induced PLCgamma2 phosphorylation, indicating that these residues include the major phosphorylation sites upon BCR engagement
Che et al., Circulation 2001 : Overexpression of Bcr also enhanced PDGF induced Ras/Raf-1 activity and DNA synthesis, but this regulation is independent of the kinase activity of Bcr
Benschop et al., J Immunol 2001 : BCR induced tyrosine phosphorylation of CD79a, Lyn, B cell linker protein , and phospholipase Cgamma2 is enhanced in immature B cells and they exhibit greater capacitative calcium entry in response to Ag ... BCR induced tyrosine phosphorylation of CD79a , Lyn, B cell linker protein, and phospholipase Cgamma2 is enhanced in immature B cells and they exhibit greater capacitative calcium entry in response to Ag ... BCR induced tyrosine phosphorylation of CD79a, Lyn , B cell linker protein, and phospholipase Cgamma2 is enhanced in immature B cells and they exhibit greater capacitative calcium entry in response to Ag ... BCR induced tyrosine phosphorylation of CD79a, Lyn, B cell linker protein, and phospholipase Cgamma2 is enhanced in immature B cells and they exhibit greater capacitative calcium entry in response to Ag
Okazaki et al., Proc Natl Acad Sci U S A 2001 : These results show that PD-1 can inhibit BCR signaling by recruiting SHP-2 to its phosphotyrosine and dephosphorylating key signal transducers of BCR signaling ... These results show that PD-1 can inhibit BCR signaling by recruiting SHP-2 to its phosphotyrosine and dephosphorylating key signal transducers of BCR signaling
Banerji et al., Oncogene 2001 (Lymphoma, B-Cell...) : We show that BCR stimulation of WEHI 231 cells results in down-regulation of cyclin D2 and up-regulation of p27 ( Kip1 ), which are associated with pocket protein hypophosphorylation and E2F inactivation ... We show that BCR stimulation of WEHI 231 cells results in down-regulation of cyclin D2 and up-regulation of p27 ( Kip1 ), which are associated with pocket protein hypophosphorylation and E2F inactivation
Yokohari et al., Biochem Biophys Res Commun 2001 : Here we show that overexpression of BRDG1 strongly augments BCR mediated activation of cAMP-response element binding protein ( CREB ) but not that of c-Jun and the promoters of c-MYC and BCL-xL genes
Perrotti et al., Nat Genet 2002 (Blast Crisis...) : BCR-ABL suppresses C/EBPalpha expression through inhibitory action of hnRNP E2
Niiro et al., J Exp Med 2002 (Calcium Signaling) : Moreover, BCR induced activation of extracellular signal regulated kinase ( ERK ), c-jun NH2-terminal kinase ( JNK ), and p38 mitogen activated protein kinase ( MAPK ) pathways was impaired in Bam32 ( -/- ) cells but not the activation of Akt related pathways ... Moreover, BCR induced activation of extracellular signal regulated kinase ( ERK ), c-jun NH2-terminal kinase ( JNK ), and p38 mitogen activated protein kinase ( MAPK ) pathways was impaired in Bam32 ( -/- ) cells but not the activation of Akt related pathways
Bassermann et al., J Biol Chem 2002 : The oncogenic tyrosine kinase Bcr-Abl has been shown to activate Rac-1 , which is important for Bcr-Abl induced leukemogenesis ... Activation of Rac-1 by Bcr-Abl was abrogated by co-expression of the Vav C terminus encoding the SH3-SH2-SH3 domains as a dominant negative construct
Abe et al., Ann N Y Acad Sci 2001 : A dominant negative Ras did not inhibit Bcr kinase activation, and overexpression of Bcr increased Ras/Raf-1 activity and DNA synthesis
Piatelli et al., J Biol Chem 2002 : Disruption of endogenous heat shock protein 90 (hsp90) function with geldanamycin abrogated BCR induced cyclin D2 expression and proliferation
Spiekermann et al., Exp Hematol 2002 (Cell Transformation, Neoplastic...) : Stable transfection of BA/F3 cells with TEL-JAK2, TEL-ABL, and BCR-ABL resulted in IL-3 independent growth and strong activation of STAT3 and STAT5 by TEL-JAK2 and TEL-ABL, but not by BCR-ABL ... Stable transfection of BA/F3 cells with TEL-JAK2, TEL-ABL, and BCR-ABL resulted in IL-3 independent growth and strong activation of STAT3 and STAT5 by TEL-JAK2 and TEL-ABL, but not by BCR-ABL
Kövesdi et al., Cell Signal 2002 (Calcium Signaling) : Both BLNK and phospholipase C ( PLC ) gamma were raft associated in unstimulated pre-B cells, and this could not be enhanced by pre-BCR engagement, suggesting a ligand independent PLC gamma mediated signaling
Tsubata et al., Int Rev Immunol 2001 : BCR proximal signaling occurs within cholesterol- and sphingolipid-rich plasma membrane microdomains termed lipid rafts, and involves tyrosine kinases such as Lyn, Syk and Btk and the adapter molecule SLP65/BLNK
Pierce et al., Hematol J 2001 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : This enhanced BCR/ABL mediated growth inhibition occurred over a range of growth factor concentrations and was independent of changes in p21 ( Cip1 ) and p27 ( Kip ) levels ... This enhanced BCR/ABL mediated growth inhibition occurred over a range of growth factor concentrations and was independent of changes in p21 ( Cip1 ) and p27 ( Kip ) levels
Inabe et al., FEBS Lett 2002 (Agammaglobulinemia) : Recent studies have shown that Btk plays an important role in BCR mediated c-Jun NH ( 2 ) -terminal kinase ( JNK ) 1 activation ; however, the mechanism by which Btk participates in the JNK1 response remains elusive
Jacob et al., J Biol Chem 2002 : Here we demonstrate through the use of PI 3-kinase inhibitors and a dominant negative PI 3-kinase construct that the BCR induced phosphorylation and activation of ERK is dependent on PI 3-kinase
Lajaunias et al., J Immunol 2002 (Calcium Signaling) : Moreover, in CD22-deficient mice, anti-IgM treatment did not trigger enhanced Ca ( 2+ ) influx in CD5 ( + ) B-1 cells, unlike CD22-deficient splenic B-2 cells, suggesting a relatively limited role of CD22 in BCR signaling in B-1 cells
Kawauchi et al., Int J Hematol 2002 (Leukemia, Lymphocytic, Chronic, B-Cell...) : In B-CLL cells, BCR cross linking neither induced activation nor enhanced the activities of Lyn, Syk, p21ras, JNK, p38 MAPK , or Akt kinases, whereas p38 MAPK and Akt were constitutively active ... In B-CLL cells, BCR cross linking neither induced activation nor enhanced the activities of Lyn , Syk, p21ras, JNK, p38 MAPK, or Akt kinases, whereas p38 MAPK and Akt were constitutively active
Korus et al., Oncogene 2002 (MAP Kinase Signaling System) : NF-kappaB activation by Bcr is not mediated by nuclear translocation, but rather by p38 mitogen activated protein kinase ( MAPK ) -dependent modification of the RelA/p65 transactivation domain
Era et al., Int J Hematol 2002 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : Although a great amount of knowledge has been accumulated, the effect of Bcr-Abl on the HSC is still unclear
Keeshan et al., Leukemia 2002 : High Bcr-Abl expression prevents the translocation of Bax and Bad to the mitochondrion
Sen et al., Mol Immunol 2002 : In both B-1 and B-2 cells BCR cross linking induced a modest increase of CD19 associated Lyn , a Src family protein tyrosine kinase ( PTK ) thought to be important for CD19 phosphorylation
Xie et al., Oncogene 2002 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : Jak2 is involved in c-Myc induction by Bcr-Abl ... In summary, our findings indicate that Jak2 mediates the increase in c-Myc expression that is induced by Bcr-Abl
Mongini et al., Cell Immunol 2002 : In the absence of IL-4, BCR : CD21 co-ligation augmented BCR triggered CD86 only under conditions of very low BCR ligand dose or affinity, and CD80 was minimally induced by BCR and/or CD21 crosslinking
Grill et al., Blood 2002 (MAP Kinase Signaling System) : Rac-1 was also activated by colony stimulating factor-1 (CSF-1), Steel locus factor ( SLF ), granulocyte-macrophage colony stimulating factor ( GM-CSF ), and IL-5 or by cross linking the B-lymphocyte receptor for antigen (BCR)
Jiang et al., Blood 2002 (Cell Transformation, Neoplastic...) : These findings provide new evidence that IL-3 production is a rapid, sustained, and biologically relevant consequence of BCR-ABL expression in primitive hematopoietic cells with multilineage leukemogenic activity
Chen et al., Blood 2002 (Diseases in Twins...) : Following BCR ligation, ZAP-70 underwent tyrosine phosphorylation and became associated with surface immunoglobulin and CD79b, arguing for the involvement of ZAP-70 in BCR signaling
Mayerhofer et al., Blood 2002 : BCR/ABL induces expression of vascular endothelial growth factor and its transcriptional activator, hypoxia inducible factor-1alpha, through a pathway involving phosphoinositide 3-kinase and the mammalian target of rapamycin ... We show here that the CML associated oncogene BCR/ABL induces VEGF gene expression in growth factor dependent Ba/F3 cells ... BCR/ABL induced VEGF gene expression was counteracted by the phosphoinositide 3-kinase ( PI3-kinase ) inhibitor LY294002 and rapamycin, an antagonist of mammalian target of rapamycin (mTOR), but not by inhibition of the mitogen activated protein kinase pathway ... Similarly, BCR/ABL dependent HIF-1alpha expression was inhibited by the addition of LY294002 and rapamycin
Schuster et al., Blood 2003 : In contrast, the up-regulation of PU.1 and p27 ( Kip1 ) by G-CSF was not affected by Bcr-Abl ... Importantly, incubation of 32D ( Bcr-Ablwt ) cells with the kinase inhibitor imatinib mesylate prior to G-CSF stimulation completely neutralized the effects of Bcr-Abl on granulocytic differentiation and on C/EBPalpha and C/EBPepsilon expression ... Importantly, incubation of 32D ( Bcr-Ablwt ) cells with the kinase inhibitor imatinib mesylate prior to G-CSF stimulation completely neutralized the effects of Bcr-Abl on granulocytic differentiation and on C/EBPalpha and C/EBPepsilon expression
Wilson et al., Oncogene 2002 (Cell Transformation, Neoplastic...) : These data implicate the Src kinase family in Stat5 and Erk activation downstream of Bcr-Abl , and identify myeloid-specific Src kinases as potential drug targets in CML
Ebos et al., Mol Cancer Res 2002 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive...) : Imatinib mesylate ( STI-571 ) reduces Bcr-Abl mediated vascular endothelial growth factor secretion in chronic myelogenous leukemia ... Transfection of BCR-ABL into murine myeloid 32D and human megakaryocyte MO7e hematopoietic cells resulted in enhanced VEGF expression, which could be further elevated by the exposure to cytokines such as interleukin 3 and granulocyte macrophage colony stimulating factor
Frissora et al., Eur J Immunol 2003 : Stimulation through BCR resulted in dose dependent induction of CREB-1 binding to the consensus cyclic AMP-responsive element ... Recombinant IFN-gamma inhibited the BCR induced CREB-1 DNA binding activity and cell proliferation in B cells from signal transducer and activator of transcription-1 ( STAT-1 ) ( +/+ ), but not STAT-1 ( -/- ) mice
Glassford et al., Oncogene 2003 (Calcium Signaling...) : Collectively, these data provide evidence for the concept that the B-cell signalosome ( p85alpha, Btk, BLNK and PLCgamma ) is involved in regulating cyclin D2 expression in response to BCR engagement
Marshall-Clarke et al., Immunology 2003 : We show that activity of the enzyme phosphatidylinositol 3-kinase is critical for MHC II hyperexpression and induction of CD86 in response to ligation of the BCR or CD38, but not for responses to other stimuli including interleukin-4, lipopolysaccharide and CD40 ligation
Johmura et al., Immunity 2003 : We demonstrate here that adaptor molecules Grb2 and BLNK, in addition to Vav, are required for efficient Rac1 activation in response to BCR stimulation
Hanson et al., J Biol Chem 2003 : Consistent with this, evidence has been presented that NF kappa B activity is required for Ras and BCR-ABL to transform cells ... The data presented here indicate that BCR-ABL expression in 32D myeloid cells or oncogenic Ras expression in murine fibroblasts blocks the ability of tumor necrosis factor (TNF) to activate NF kappa B
Yu et al., Blood 2003 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : These events were accompanied by down-regulation of the Raf-1/mitogen induced extracellular kinase ( MEK ) /extracellular signal related kinase ( ERK ) pathway as well as diminished expression of Bcr/Abl and cyclin D1, cleavage of p21CIP1 and phosphorylation of the retinoblastoma protein ( pRb ), and induction of the stress related kinases Jun kinase (JNK) and p38 mitogen activated protein kinase ( MAPK )
Christian et al., J Biol Chem 2003 : Preventing Rap activation also increased the ability of the BCR to stimulate Akt dependent phosphorylation of the FKHR transcription factor on negative regulatory sites and decreased the levels of p27Kip1, a pro-apoptotic factor whose transcription is enhanced by FKHR ... Thus activation of endogenous Rap by the BCR limits BCR induced activation of the PI3K/Akt pathway, opposes the subsequent inhibition of the FKHR/p27Kip1 pro-apoptotic module, and enhances BCR induced cell death ... Consistent with the idea that Rap-GTP is a negative regulator of the PI3K/Akt pathway, expressing constitutively active Rap2 ( Rap2V12 ) reduced BCR induced phosphorylation of Akt and FKHR ... Consistent with the idea that Rap-GTP is a negative regulator of the PI3K/Akt pathway, expressing constitutively active Rap2 ( Rap2V12 ) reduced BCR induced phosphorylation of Akt and FKHR
Hao et al., EMBO J 2003 : We show here that like NFAT, BCR regulation of SRF occurs via an Src-Syk-Tec-PLCgamma-Ca ( 2+ ) ( Lyn-Syk-Btk-PLCgamma-Ca ( 2+ ) ) pathway
Wen et al., J Biol Chem 2003 : PLCgamma2 plays a critical role in B cell receptor (BCR) signaling and its targeted deletion results in defective B cell development and function
Masilamani et al., Eur J Immunol 2003 : CD21 shedding is induced by stimulation with PMA plus Ca ( 2+ ) ionophore, or by stimulation of the BCR with anti-IgM+anti-CD40
Barel et al., Eur J Immunol 2003 (Epstein-Barr Virus Infections) : The specificity of CR2 pathway was clearly demonstrated as neither CD19 nor BCR could induce tyrosine phosphorylation of nucleolin in normal B lymphocytes
Keeshan et al., Br J Haematol 2003 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : Bcr-Abl upregulates cytosolic p21WAF-1/CIP-1 by a phosphoinositide-3-kinase (PI3K) independent pathway
Haxhinasto et al., J Immunol 2003 : In this study, we show that genetic or pharmacologic inhibition of BCR mediated PKD activation in B lymphocytes abrogated the synergy between the CD40 and the BCR, as measured by activation of Ig and cytokine secretion
Su et al., J Exp Med 2003 : This SL-deficient pre-BCR ( SL-pre-BCR ) requires Ig-alpha for expression on the cell surface
Gustafson et al., J Biol Chem 2004 (Cell Transformation, Neoplastic) : Bcr-Abl regulates protein kinase Ciota (PKCiota) transcription via an Elk1 site in the PKCiota promoter
Kim et al., Br J Haematol 2004 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : Imatinib/apicidin co-treatment for 48 h produced a prominent decrease in Bcr-Abl protein levels in a caspase dependent manner ... In summary, these data indicate that apicidin potentiates the imatinib induced apoptosis of Bcr-Abl positive leukaemia cells through the enhanced activation of the mitochondria dependent caspase cascades, accompanied by caspase dependent downregulation of Bcr-Abl and XIAP
Cherukuri et al., J Immunol 2004 : Using B cells from CD81-deficient mice we demonstrate that in the absence of CD81, coligated BCR and CD19/CD21 complexes fail to partition into lipid rafts and enhance BCR signaling from rafts ... Using B cells from CD81-deficient mice we demonstrate that in the absence of CD81, coligated BCR and CD19/CD21 complexes fail to partition into lipid rafts and enhance BCR signaling from rafts
Gaston et al., Exp Hematol 2004 : In a yeast three-hybrid assay, Grb2 mediated an interaction between Cbl and Bcr-Abl that was dependent on a functional Grb2 binding site ... Grb2 or another, yet unidentified, protein may mediate an initial interaction between Cbl and Bcr-Abl that is independent of Cbl tyrosine phosphorylation
Portis et al., Virology 2004 : LMP2A inhibits B-cell receptor (BCR) signaling in vitro and allows for the survival of BCR negative B cells in vivo
Patke et al., Curr Opin Immunol 2004 : BCR signaling leads to activation of the inhibitor of NF-kappa B kinase (IKK) complex via Carma1, Bcl10 and MALT1, whereas BAFF-R engagement promotes processing of NF-kappa B2 protein p100, which is dependent on NF-kappa B-inducing kinase (NIK) and IKK alpha
Viau et al., Immunol Lett 2004 : To test this hypothesis, we investigated the potential effects of a SAg , protein L from Peptostreptococcus magnus, on antigen B cell receptor (BcR) surface expression in vitro ... These data demonstrate that SAg mediated down-regulation of the BcR expression occurs primarily as a result of BcR internalization
Chandramohan et al., J Immunol 2004 : We demonstrate that pharmacologic inhibitors of PI3K or BCR engagement lead to decreased inactive cytoplasmic levels and increased active functional nuclear FOXO3a
Blois et al., J Biol Chem 2004 : In addition, BCR induced CREB phosphorylation is significantly diminished in nPKCdelta-deficient splenic B cells in comparison with wild type mice ... Taken together, these results suggest a model in which BCR engagement leads to the phosphorylation of CREB via a signaling pathway that requires nPKCdelta and p90 RSK in mature B cells
Kövesdi et al., Cell Signal 2004 (MAP Kinase Signaling System) : We have detected a short lived BCR-driven activation of mitogen activated protein kinases ( ERK1/2 and p38 MAPK ) and Akt/PKB in transitional immature B cells that correlated with the lack of c-Fos expression, reduced phosphorylation of Akt substrates and a susceptibility for apoptosis
Leis et al., Leukemia & lymphoma 2004 (Blast Crisis...) : CSF levels were substantially below the concentration required for inhibition of BCR-ABL and killing of cell lines in vitro
Moon et al., Cell Immunol 2004 (Autoimmune Diseases...) : Lyn , the src-family protein tyrosine kinase, plays a crucial role in the regulation of B cell antigen receptor (BCR)- and IL-5-receptor (IL-5R) mediated signaling
Bandyopadhyay et al., Blood 2004 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive...) : NaChl did not increase phosphorylation of p38 in Bcr-Abl negative cells including HSC-2 and HSG that are responsive to this compound, indicating that p38 activation by NaChl is dependent on Bcr-Abl kinase inhibition
Ehrhardt et al., Mol Cell Biol 2004 : In contrast, ligation of the BCR or TCR resulted in activation of H-Ras , N-Ras, and K-Ras 4B, but not M-Ras ... In contrast, ligation of the BCR or TCR resulted in activation of H-Ras, N-Ras, and K-Ras 4B, but not M-Ras ... In contrast, ligation of the BCR or TCR resulted in activation of H-Ras, N-Ras , and K-Ras 4B, but not M-Ras
Tian et al., Chin J Cancer 2004 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : BCR-ABL fusion gene is regarded as the molecular hallmark of chronic myelogenous leukemia ( CML ), and its expression is controlled by the BCR gene promoter
Taguchi et al., Immunology 2004 : When pre-BCR was cross linked with anti-micro heavy-chain antibodies, significant phosphorylation of intracellular molecules, including Syk, Shc, ERK MAP kinase, and AKT, and an activation of Ras were observed without regard to deficiency of BLNK expression, suggesting that BLNK is not required for pre-BCR mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signalling
Tybulewicz et al., Eur J Immunol 2004 (Second Messenger Systems) : Unexpectedly, they show that while the BCR induced phosphorylation of the PI3K dependent kinase Akt is reduced in p85alpha-deficient cells, the phosphorylation of two downstream targets of Akt -- FOXO1 and ribosomal protein S6 -- is largely unaffected
Katzman et al., J Virol 2004 : LMP2A prevents BCR recruitment to lipid rafts, thereby abrogating BCR function
Lin et al., Semin Immunol 2004 (Lymphoma, B-Cell, Marginal Zone) : Recent studies demonstrate that CARMA1, a scaffold protein, plays an essential role in mediating TCR- or BCR induced NF-kappaB activation by recruiting two adaptor proteins, Bcl10 and MALT1, to lipid rafts following stimulation of antigen receptors
Deming et al., Mol Cell Biol 2004 : We report here that Bcr-Abl also inhibits caspase activation after the release of cytochrome c. Bcr-Abl inhibited caspase activation by cytochrome c added to cell-free lysates and prevented apoptosis when cytochrome c was microinjected into intact cells
Mizuchi et al., Biochem Biophys Res Commun 2005 : Here we demonstrate that the inducible expression of BCR/ABL in a murine hematopoietic cell line, TonB210, leads to the activation of the Ras family small GTPase Rap1 , which is inhibited by the ABL kinase inhibitor imatinib
Aichberger et al., Blood 2005 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : BCR/ABL dependent expression of MCL-1 in Ba/F3 cells was counteracted by the mitogen activated protein-kinase/extracellular signal regulated kinase ( MEK ) inhibitor, PD98059, but not by the phosphoinositide 3-kinase inhibitor, LY294002
Fuentes-Pananá et al., J Immunol 2005 : Ligand induced BCR association with detergent-resistant plasma membrane compartments ( lipid rafts ) has been argued to be essential for initiating and/or sustaining Igalpha/Igbeta dependent BCR signaling ... Ligand induced BCR association with detergent-resistant plasma membrane compartments ( lipid rafts ) has been argued to be essential for initiating and/or sustaining Igalpha/Igbeta dependent BCR signaling
Saci et al., Mol Cell 2005 : Here, we show that RhoA is activated, downstream of PI3K, in response to BCR stimulation and is important for BCR dependent calcium flux and cell proliferation
Xu et al., J Interferon Cytokine Res 2005 : Furthermore, we show that both the p38 mitogen activated protein kinase ( MAPK ) and the Ca ( 2+ ) /calmodulin dependent kinase ( CaMKII ) are activated in response to BCR signaling to converge on Stat1 S727 for maximal gene expression
Weisberg et al., Cancer Cell 2005 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive...) : Characterization of AMN107 , a selective inhibitor of native and mutant Bcr-Abl
Barnes et al., Oncogene 2005 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : Both IL-3 treatment and expression of Bcr-Abl led to enhanced phosphorylation of Akt ( protein kinase B )
Slupianek et al., Oncogene 2005 (Leukemia) : BCR/ABL promotes interactions of BLM with RAD51, while simultaneous overexpression of BLM and RAD51 in normal cells increases drug resistance
Geay et al., Cancer Res 2005 (Blast Crisis...) : However, higher p210 ( BCR-ABL ) expression induced a marked down-regulation of CXCR4 that is related to its decreased transcription
Guo et al., J Immunol 2005 : B cell receptor (BCR) cross-talk : IL-4 creates an alternate pathway for BCR induced ERK activation that is phosphatidylinositol 3-kinase independent
Hickey et al., J Leukoc Biol 2005 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : Here, we demonstrate that OPN expression is induced in a model of leukemia, and we describe the identification of specific signaling pathways required for the induction of OPN expression by p210 Bcr-Abl
Gadzicki et al., Cancer Genet Cytogenet 2005 (Chromosome Aberrations...) : We give further evidence that the genomic BCR-ABL amplification results in an increased level of BCR-ABL transcript linking two potent mechanisms of resistance against imatinib treatment ... We give further evidence that the genomic BCR-ABL amplification results in an increased level of BCR-ABL transcript linking two potent mechanisms of resistance against imatinib treatment
Feldhahn et al., J Exp Med 2005 (Calcium Signaling...) : Acting as a linker, truncated BTK enables BCR-ABL1 dependent activation of full-length BTK , which initiates downstream survival signals and mimics a constitutively active pre-B cell receptor
Agirre et al., Cancer Genet Cytogenet 2005 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : Loss of normal BCR in one cell clone may contribute to the resistance to imatinib due to the lack of BCR mediated inhibition of BCR-ABL1 ... Loss of normal BCR in one cell clone may contribute to the resistance to imatinib due to the lack of BCR mediated inhibition of BCR-ABL1
Francés et al., J Immunol 2005 (Calcium Signaling) : The same B-1 cells manifested defective BCR mediated induction of IKKbeta phosphorylation, IkappaBalpha degradation, and intracellular Ca ( 2+ ) mobilization ... The same B-1 cells manifested defective BCR mediated induction of IKKbeta phosphorylation, IkappaBalpha degradation, and intracellular Ca ( 2+ ) mobilization
Flamant et al., Biochem Biophys Res Commun 2005 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : Studies using mutant forms of BCR-ABL demonstrated that the BCR-ABL induced OPN overexpression was a tyrosine kinase dependent event
Golemovic et al., Clin Cancer Res 2005 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : AMN107 , a novel aminopyrimidine inhibitor of Bcr-Abl , has in vitro activity against imatinib-resistant chronic myeloid leukemia
Nakamura et al., Oncogene 2005 (Cell Transformation, Neoplastic...) : These results indicate that MEKK1 plays a key role in Bcr-Abl induced STAT3 activation and in ES cells ' capacity for LIF independent self-renewal, and may thus be involved in Bcr-Abl mediated leukemogenesis in stem cells
Glassford et al., Eur J Immunol 2005 : Furthermore, using both p85alpha-null and p110delta-null B cells and inhibitors of PI3K, this study demonstrates for the first time, that BCR cross linking induces cyclin D2 mRNA expression via transcriptional activation of the cyclin D2 promoter and that this transcriptional activation of cyclin D2 requires PI3K activity ... Furthermore, using both p85alpha-null and p110delta-null B cells and inhibitors of PI3K, this study demonstrates for the first time, that BCR cross linking induces cyclin D2 mRNA expression via transcriptional activation of the cyclin D2 promoter and that this transcriptional activation of cyclin D2 requires PI3K activity
Xing et al., J Exp Med 2005 : G5pr(-/-) B cells did not show abnormalities in the BCR mediated activation of Erks and NF-kappaB, cyclin D2 induction, or Akt activation ... G5pr(-/-) B cells did not show abnormalities in the BCR mediated activation of Erks and NF-kappaB, cyclin D2 induction, or Akt activation ... G5pr(-/-) B cells did not show abnormalities in the BCR mediated activation of Erks and NF-kappaB , cyclin D2 induction, or Akt activation ... G5pr(-/-) B cells did not show abnormalities in the BCR mediated activation of Erks and NF-kappaB, cyclin D2 induction, or Akt activation
Bilancio et al., Blood 2006 : p110delta activity is indispensable for BCR induced DNA synthesis and phosphorylation of Akt/protein kinase B (PKB), forkhead transcription factor/forkhead box O3a (FOXO3a), and p70 S6 kinase (p70 S6K), with modest effects on the phosphorylation of glycogen synthase kinase 3 alpha/beta ( GSK3alpha/beta ) and extracellular signal regulated kinase ( Erk ) ... p110delta activity is indispensable for BCR induced DNA synthesis and phosphorylation of Akt/protein kinase B (PKB), forkhead transcription factor/forkhead box O3a (FOXO3a) , and p70 S6 kinase (p70 S6K), with modest effects on the phosphorylation of glycogen synthase kinase 3 alpha/beta ( GSK3alpha/beta ) and extracellular signal regulated kinase ( Erk ) ... p110delta activity is indispensable for BCR induced DNA synthesis and phosphorylation of Akt/protein kinase B (PKB) , forkhead transcription factor/forkhead box O3a (FOXO3a), and p70 S6 kinase (p70 S6K), with modest effects on the phosphorylation of glycogen synthase kinase 3 alpha/beta ( GSK3alpha/beta ) and extracellular signal regulated kinase ( Erk ) ... p110delta activity is indispensable for BCR induced DNA synthesis and phosphorylation of Akt/protein kinase B (PKB), forkhead transcription factor/forkhead box O3a (FOXO3a), and p70 S6 kinase (p70 S6K), with modest effects on the phosphorylation of glycogen synthase kinase 3 alpha/beta ( GSK3alpha/beta ) and extracellular signal regulated kinase ( Erk ) ... p110delta activity is indispensable for BCR induced DNA synthesis and phosphorylation of Akt/protein kinase B (PKB), forkhead transcription factor/forkhead box O3a (FOXO3a), and p70 S6 kinase (p70 S6K) , with modest effects on the phosphorylation of glycogen synthase kinase 3 alpha/beta ( GSK3alpha/beta ) and extracellular signal regulated kinase ( Erk )
Ress et al., EMBO Rep 2005 : Expression of Bcr in the human colon carcinoma cell line HCT116, which has a high level of endogenous beta-catenin, leads to reduced c-Myc expression
Neviani et al., Cancer Cell 2005 (Blast Crisis...) : In imatinib-sensitive and -resistant ( T315I included ) BCR/ABL+ cell lines and CML-BC progenitors, molecular and/or pharmacological activation of PP2A promotes dephosphorylation of key regulators of cell proliferation and survival, suppresses BCR/ABL activity, and induces BCR/ABL degradation ... In imatinib-sensitive and -resistant ( T315I included ) BCR/ABL+ cell lines and CML-BC progenitors, molecular and/or pharmacological activation of PP2A promotes dephosphorylation of key regulators of cell proliferation and survival, suppresses BCR/ABL activity, and induces BCR/ABL degradation
Xu et al., J Immunol 2005 : Specifically for an anti-microbial response, the recognition of viral or bacterial Ags by the BCR and the stimulation of IFN-gamma result in the predominant production of IgG2a
Giles et al., Curr Mol Med 2005 (Hematologic Neoplasms...) : FLT3 , VEGF, and BCR-ABL mediate their activities via mTOR
Lee et al., J Immunol 2005 : BCR induced CD22 phosphorylation and Src homology 2 domain containing protein tyrosine phosphatase-1/CD22 associations were also reduced, suggesting abrogation of negative regulatory signaling
Khan et al., Infect Immun 2006 : The relative role of Btk dependent B-cell receptor (BCR) signaling in the induction of antipolysaccharide ( anti-PS ) and antiprotein immunoglobulin ( Ig ) responses to an intact extracellular bacterium in vivo is unknown
Clark et al., Oncology 2006 (Leukemia) : Since Bcr/Abl induces constitutive expression of c-Myc , which is necessary for cell cycle transit from G1 into the S phase, we tested whether POH causes growth arrest by inhibiting expression of c-Myc
Nieborowska-Skorska et al., Cancer Res 2006 (Cell Transformation, Neoplastic...) : We show here that expression of the helix-loop-helix transcription factor Id1 is enhanced by BCR/ABL in a signal transducer and activator of transcription 5 ( STAT5 ) -dependent manner
Wendel et al., Proc Natl Acad Sci U S A 2006 (Disease Progression...) : We show that the tumor suppressor p53 is selectively activated by imatinib in BCR-ABL expressing cells as a result of BCR-ABL kinase inhibition
Siegel et al., Cell 2006 : This study indicates that OCA-B is required for pre-BCR and BCR signaling at multiple stages of B cell development through its nontranscriptional regulation of SYK
de la Fuente et al., Mol Cell Biol 2006 : B-cell proliferation, cell cycle progression, PLC-gamma2 phosphorylation, calcium mobilization, NF-ATp dephosphorylation, and Erk and Jnk activation in response to B-cell receptor (BCR) ligation were all impaired
Gazumyan et al., J Exp Med 2006 : BCR cross linking resulted in decreased Src and Syk activation but paradoxically enhanced and prolonged BCR signaling, as measured by cellular tyrosine phosphorylation, Ca ( ++ ) flux, AKT, and ERK activation ... BCR cross linking resulted in decreased Src and Syk activation but paradoxically enhanced and prolonged BCR signaling, as measured by cellular tyrosine phosphorylation, Ca ( ++ ) flux, AKT, and ERK activation
Irish et al., Blood 2006 (Lymphoma, B-Cell...) : The B-cell receptor (BCR) transmits life and death signals throughout B-cell development, and altered BCR signaling may be required for survival of B-lymphoma cells
Coppo et al., Br J Haematol 2006 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : BCR-ABL activates STAT3 via JAK and MEK pathways in human cells
Aichberger et al., Blood 2006 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : The CML related oncoprotein BCR/ABL induces expression of histidine decarboxylase (HDC) and the synthesis of histamine in leukemic cells
Snyder et al., Traffic 2006 : Thus, the investigation of the mechanism by which Y112-LMP2A blocks BCR function revealed an essential role for PLD in BCR trafficking for antigen processing
Chen et al., Blood 2006 (Lymphoma) : BCR dependent activation of the SYK PTK initiates downstream signaling events and amplifies the original BCR signal
Prabhu et al., Oncogene 2007 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : In this study, we found that both Bcr-Abl and the rapamycin-sensitive mTORC1 complex contribute to the phosphorylation ( inactivation ) of 4E-BP1 , an inhibitor of the eIF4E translation initiation factor ... Experiments with rapamycin and the Bcr-Abl inhibitor, imatinib mesylate, in Bcr-Abl expressing cell lines and primary CML cells indicated that Bcr-Abl and mTORC1 induced formation of the translation initiation complex, eIF4F
Sengupta et al., J Gene Med 2006 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive...) : BCR-ABL mediated chronic myelogenous leukemia ( CML ) CD34 ( + ) cell proliferation mostly depends on the nucleo-cytoplasmic ratio of the cyclin dependent kinase inhibitor p27
Gobessi et al., Blood 2007 (Leukemia, B-Cell...) : We show that BCR mediated activation of ZAP-70 is very inefficient in CLL and lymphoma B cells and is negligible when compared to activation of Syk
Pappu et al., Eur J Immunol 2006 : NF-kappaB activation through B cell receptor (BCR) ligation is critical for B cell development, survival and antigen mediated activation of B cells
Ke et al., J Biol Chem 2006 (Lymphoma, B-Cell...) : Cross linking of the B cell receptor (BCR) on the immature B lymphoma cell line BKS-2 induces growth inhibition and apoptosis accompanied by rapid down-regulation of the immediate-early gene egr-1 ... BCR induced MAPK activation was modest and transient with a small increase in egr-1 expression in normal immature B cells consistent with their inability to proliferate in response to BCR cross linking
Dragone et al., Proc Natl Acad Sci U S A 2006 : Coexpression of SLAP and c-Cbl in Bal-17 led to decreased surface and total BCR levels
Caballero et al., Eur J Immunol 2006 : The results demonstrate that Src kinases and Syk mediated BCR signaling are not essential for BCR mediated Ag internalization
Wang et al., Oncogene 2007 : Engagement of the B-cell antigen receptor (BCR) initiated by the Src kinase Lyn triggers rapid signaling cascades, leading to proliferation, differentiation or growth arrest of B cells
Iotti et al., Oncogene 2007 (Leukemia, Myeloid) : Expression of CCL9/MIP-1gamma is repressed by BCR/ABL and its restoration suppresses in vivo leukemogenesis of 32D-BCR/ABL cells ... Expression of CCL9/MIP-1gamma is repressed by BCR/ABL and its restoration suppresses in vivo leukemogenesis of 32D-BCR/ABL cells ... Expression of CCL9/MIP-1gamma is repressed by BCR/ABL and its restoration suppresses in vivo leukemogenesis of 32D-BCR/ABL cells ... BCR/ABL repressed CCL9 expression at the transcriptional level by mechanisms involving suppression of p38 MAP kinase, and modulation of the activity of CDP/cut and C/EBPalpha, two transcription regulators of myeloid differentiation
Storch et al., Eur J Immunol 2007 : We show that the Ig-alpha mutants led to comparable pre-BCR expression on the cell surface, while the pre-BCR induced tyrosine phosphorylation was different
Kantarjian et al., Ann Intern Med 2006 (Disease Progression...) : In light of the limitations of imatinib against these factors, newer tyrosine kinase inhibitors, including dasatinib ( a multitargeted kinase inhibitor of BCR-ABL and Src family kinases ) and nilotinib ( AMN107 , a selective BCR-ABL inhibitor ), may provide promising treatment options for patients with CML
Hinman et al., J Immunol 2007 : Previously, BCR induced phosphorylation of FOXO1 was shown to lead to a block in nuclear localization and subsequent protein degradation
Moriyama et al., Immunol Lett 2007 (Lymphoma, B-Cell) : Rapid up-regulation of c-FLIP expression by BCR signaling through the PI3K/Akt pathway inhibits simultaneously induced Fas mediated apoptosis in murine B lymphocytes
Coluccia et al., EMBO J 2007 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : Bcr-Abl stabilizes beta-catenin in chronic myeloid leukemia through its tyrosine phosphorylation ... These findings indicate the Bcr-Abl triggered Y phosphorylation of beta-catenin as a new mechanism responsible for its protein stabilization and nuclear signalling activation in CML
Alugupalli et al., J Immunol 2007 (Borrelia Infections) : These results suggest that MyD88 specifically promotes T cell independent BCR signaling and that, in the absence of Btk, this TLR mediated stimulation is a required component of this signal
Thompson et al., Immunity 2007 : Thus, pre-BCR signaling regulates Aiolos and the silencing of Igll1 via a developmental-stage-specific feedback loop
Perrotti et al., Clin Cancer Res 2007 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive...) : Here, we summarize the effects of increased BCR/ABL oncogenic activity on the expression and function of RNA binding proteins ( e.g., FUS, hnRNP A1, hnRNP E2, hnRNP K, and La/SSB ) with posttranscriptional and translational regulatory activities and their importance for the phenotype of BCR/ABL transformed hematopoietic progenitors ... Here, we summarize the effects of increased BCR/ABL oncogenic activity on the expression and function of RNA binding proteins ( e.g., FUS , hnRNP A1, hnRNP E2, hnRNP K, and La/SSB ) with posttranscriptional and translational regulatory activities and their importance for the phenotype of BCR/ABL transformed hematopoietic progenitors ... Here, we summarize the effects of increased BCR/ABL oncogenic activity on the expression and function of RNA binding proteins ( e.g., FUS, hnRNP A1 , hnRNP E2, hnRNP K, and La/SSB ) with posttranscriptional and translational regulatory activities and their importance for the phenotype of BCR/ABL transformed hematopoietic progenitors ... Here, we summarize the effects of increased BCR/ABL oncogenic activity on the expression and function of RNA binding proteins ( e.g., FUS, hnRNP A1, hnRNP E2, hnRNP K , and La/SSB ) with posttranscriptional and translational regulatory activities and their importance for the phenotype of BCR/ABL transformed hematopoietic progenitors ... Here, we summarize the effects of increased BCR/ABL oncogenic activity on the expression and function of RNA binding proteins ( e.g., FUS, hnRNP A1, hnRNP E2 , hnRNP K, and La/SSB ) with posttranscriptional and translational regulatory activities and their importance for the phenotype of BCR/ABL transformed hematopoietic progenitors
Angyal et al., Ann N Y Acad Sci 2006 : RNA silencing experiments showed that knocking down Gab1 adaptor protein in BL41 human Burkitt lymphoma cells significantly reduced B cell receptor (BCR) induced Erk phosphorylation, indicating that Gab1 plays a pivotal role in regulating Erk activity in B cells
Li et al., J Cell Sci 2007 : Expression of Bcr-Abl induces tyrosine phosphorylation of Abi1 ... Bcr-Abl induced membrane translocation of Abi1/WAVE2 requires direct interaction between Abi1 and Bcr-Abl, but is independent of the phosphoinositide 3-kinase pathway ... Bcr-Abl induced membrane translocation of Abi1/WAVE2 requires direct interaction between Abi1 and Bcr-Abl, but is independent of the phosphoinositide 3-kinase pathway
Rechsteiner et al., J Gen Virol 2007 (Burkitt Lymphoma) : Epstein-Barr virus ( EBV ) latent membrane protein 2A (LMP2A) blocks B-cell receptor (BCR) signalling after BCR cross linking to inhibit activation of lytic EBV, and ectopically expressed LMP2B negatively regulates LMP2A
Rink et al., Blood 2007 (Leukemia) : Here we show that BCR/ABL stimulated Nbs1 expression by induction of c-Myc dependent transactivation and protection from caspase dependent degradation
Chang et al., Blood 2007 (Blast Crisis...) : In fact, high levels of p210-BCR/ABL are required for enhanced hnRNP-E2 expression, which depends on phosphorylation of hnRNP-E2 serines 173, 189, and 272 and threonine 213 by the BCR/ABL activated MAPK(ERK1/2)
Poincloux et al., J Cell Physiol 2007 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : In chronic myeloid leukemia ( CML ), the transforming activity of Bcr/Abl involves constitutive activation of the phagocyte specific Src-family tyrosine kinase Hck , which in turn directly activates the signal transducer and activator of transcription 5 ( STAT5 )
Kohl et al., Leukemia 2007 (Acute Disease...) : In contrast to AML cell lines, BCR-ABL transformed human cells showed resistance to ABT-737, which might be due to the induction of MCL1 by BCR-ABL
Beaulieu et al., Mol Biol Cell 2007 (Cell Transformation, Neoplastic) : We found that the C1 domain can contribute to plasma membrane targeted translocation of RasGRP1 induced by ligation of the B cell antigen receptor (BCR)
Bai et al., Mol Cell Biol 2007 : Phospholipase Cgamma2 ( PLCgamma2 ) is critical for pre-B-cell receptor ( pre-BCR ) and BCR signaling ... Importantly, PLCgamma2 deficiency impaired BCR induced expression of IRF-4 and IRF-8 , the two transcription factors critical for lambda and kappa light-chain rearrangements ... Importantly, PLCgamma2 deficiency impaired BCR induced expression of IRF-4 and IRF-8, the two transcription factors critical for lambda and kappa light-chain rearrangements
Li et al., Oncogene 2007 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : Our data indicated that BCR/ABL induces SPK1 expression and increases its cellular activity, leading to upregulation of Mcl-1 in CML cells ... Our data indicated that BCR/ABL induces SPK1 expression and increases its cellular activity, leading to upregulation of Mcl-1 in CML cells
Yu et al., Biochem Biophys Res Commun 2007 : Previous studies demonstrated that synthetic sialosides that bind to CD22 augment BCR signaling by inhibiting CD22 mediated BCR regulation
Chu et al., Cancer Res 2007 (Cell Transformation, Neoplastic...) : BCR/ABL expression results in enhanced Ras and Akt activity but reduced mitogen activated protein kinase activity in human hematopoietic cells, which is reversed by BCR/ABL-Y177 mutation ... BCR/ABL expression results in enhanced Ras and Akt activity but reduced mitogen activated protein kinase activity in human hematopoietic cells, which is reversed by BCR/ABL-Y177 mutation
Avramidou et al., Cell Death Differ 2007 : The novel adaptor protein Swiprosin-1 enhances BCR signals and contributes to BCR induced apoptosis
Craxton et al., Eur J Immunol 2007 : Likewise, BCR induced p27 ( Kip1 ) degradation was decreased in Bim KO compared to WT B cells
Donahue et al., Eur J Immunol 2007 : We used flow cytometry and magnetic cell sorting to examine the requirement for PI3K and mTOR in responses of splenic B cell subsets to BCR and LPS stimulation ... We used flow cytometry and magnetic cell sorting to examine the requirement for PI3K and mTOR in responses of splenic B cell subsets to BCR and LPS stimulation
Brezski et al., J Immunol 2007 : In this study, we show that in mature B cells, BCR signaling triggers Vav phosphorylation and Rac1 activation ... Because transitional immature murine B cells maintain lower steady-state levels of plasma membrane cholesterol, we augmented their levels to that of mature B cells and found that BCR induced Rac1 activation and Rac1 dependent membrane ruffling and cell spreading were restored
Sahay et al., Oncogene 2008 (Cell Transformation, Neoplastic...) : p210 Bcr-Abl can stimulate RhoA activation independently of its tyrosine kinase activity, and mutations within the RhoGEF domain that are predicted to eliminate RhoGEF activity inhibit RhoA activation
Chen et al., Blood 2008 (Lymphoma, Large B-Cell, Diffuse) : Ligand induced BCR signaling induces receptor oligomerization, Igalpha/beta immunoreceptor tyrosine based activation motif ( ITAM ) phosphorylation, and activation of the spleen tyrosine kinase (SYK) , which initiates downstream events and amplifies the initial BCR signal
Zhu et al., J Biol Chem 2008 : We demonstrate that the CD22 mutant in which both Tyr ( 843 ) and Tyr ( 863 ) are replaced by phenylalanine ( CD22F5/6 ) recruits SHP-1 and regulates BCR signaling upon stimulation with antigen but not anti-Ig Ab
Hussain et al., J Immunol 2007 (Diabetes Mellitus, Type 1) : Consistent with this result, severe insulitis was observed in the islets of NOD recipients of transfused NOD.IL-10 ( -/- ) BCR stimulated B cells but not in the islets of NOD recipients of transfused BCR stimulated NOD B cells ... Consistent with this result, severe insulitis was observed in the islets of NOD recipients of transfused NOD.IL-10 ( -/- ) BCR stimulated B cells but not in the islets of NOD recipients of transfused BCR stimulated NOD B cells
Konig et al., Blood 2008 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : SKI-606 effectively inhibited Bcr-Abl kinase activity in CML CD34 ( + ) cells and inhibited Src phosphorylation more potently than imatinib ... SKI-606 effectively inhibited Bcr-Abl kinase activity in CML CD34 ( + ) cells and inhibited Src phosphorylation more potently than imatinib
Shinohara et al., J Exp Med 2007 : We show that PKCbeta mediates phosphorylation of CARMA1 on Ser668, which in turn is essential for BCR mediated CARMA1-Bcl10-mucosal associated lymphoid tissue 1 ( MALT1 ) association and subsequent IKK activation
Sohn et al., J Immunol 2008 : That lipid rafts play a role in FcgammaRIIB 's regulation of BCR signaling was suggested by recent studies showing that a lupus associated loss of function mutation resulted in the receptor 's exclusion from lipid rafts and the failure to regulate BCR signaling
Ban et al., Blood 2008 (Blast Crisis...) : BCR-ABL1 mediates up-regulation of Fyn in chronic myelogenous leukemia
Mättö et al., Scand J Immunol 2008 : BCR stimulation also stabilized and enhanced the IFN-gamma mRNA production induced by IL-12 and IL-18
Duncan et al., Mol Cancer Ther 2008 : Additionally, we reported previously that BCR-ABL activates the transcription factor nuclear factor-kappaB (NF-kappaB) in a manner dependent on Ras and that inhibition of NF-kappaB by expression of a modified form of IkappaBalpha blocked BCR-ABL-driven tumor growth in a xenograft model ... These data indicate that blockage of BCR-ABL induced NF-kappaB activation via IkappaB kinase beta inhibition represents a potential new approach for treatment of Imatinib- or Dasatinib-resistant forms of chronic myelogenous leukemia
Lakshmikuttyamma et al., Oncogene 2008 (Blast Crisis...) : Bcr-Abl induces autocrine IGF-1 signaling
Onabajo et al., J Immunol 2008 : Mutations of the two tyrosine phosphorylation sites of Abp1 and depolymerization of the actin cytoskeleton interfered with BCR induced Abp1 recruitment to the plasma membrane ... These results demonstrate that the BCR regulates the function of Abp1 by inducing Abp1 phosphorylation and actin cytoskeleton rearrangement, and that Abp1 facilitates BCR mediated Ag processing by simultaneously interacting with dynamin and the actin cytoskeleton
Lee et al., Journal of cell communication and signaling 2007 : In contrast, BCR induced activation of ERK, JNK, p38 , and Akt was not affected by ROS depletion ... In contrast, BCR induced activation of ERK , JNK, p38, and Akt was not affected by ROS depletion ... In contrast, BCR induced activation of ERK, JNK, p38, and Akt was not affected by ROS depletion
Bueno et al., Cancer Cell 2008 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive...) : Genetic and epigenetic silencing of microRNA-203 enhances ABL1 and BCR-ABL1 oncogene expression
Wu et al., J Natl Cancer Inst 2008 (Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative) : LYN activation was independent of BCR-ABL in cells from imatinib-resistant patients
Ha et al., J Leukoc Biol 2008 : We found that in CB B cells activation of extracellular signal regulated kinase ( ERK ) and p38 following ligation of CD40 but not of the B-cell antigen receptor (BCR) was inefficient ... We found that in CB B cells activation of extracellular signal regulated kinase ( ERK ) and p38 following ligation of CD40 but not of the B-cell antigen receptor (BCR) was inefficient
Bhattacharyya et al., Ann Hematol 2009 (Blast Crisis...) : Since we further found that overexpression of BCR-ABL in human embryonic kidney-293 cells enhanced BMI-1 expression and that BMI-1 expression was increased in K562 cells, derived from patients with BC, in the presence of proteasomal inhibitors, BMI-1 was presumed to be positively regulated by BCR-ABL and further by posttranscriptional modification in the course of the disease progression
Crowley et al., Blood 2009 : These studies investigate how interactions between the BCR and FcgammaRIIB affect B lymphocyte stimulator (BLyS) recep-tor expression and signaling
Yi et al., Int J Mol Med 2008 (Precursor Cell Lymphoblastic Leukemia-Lymphoma) : The binding of Bcr/Abl to Spa-1 may cause aberrant subcellular location of Spa-1 and affect migration of these cells
Minguet et al., Eur J Immunol 2008 : Our data suggest that TLR4 and BCR induce CD69 transcription via two distinct sets of signalling molecules, exerting quantitative and qualitative differences in B-cell activation
Li et al., Arthritis Rheum 2008 (Autoimmune Diseases) : Biochemical analyses indicated that in anergic B cells, CD72 dominantly down-regulated BCR signaling to limit the antigen induced elevation in [ Ca2+ ] i and the activation of NFATc1, NF-kappaB, MAPK, and Akt ... Mechanistically, CD72 was associated with, and regulated, the molecular adaptor Cbl-b in anergic B cells, suggesting that Cbl-b may play a role in mediating the negative effects of CD72 on BCR signaling
Konig et al., Cancer Res 2008 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : In contrast, Imatinib inhibited only Bcr-Abl dependent Src activity
Mahon et al., Cancer Res 2008 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : Two Src kinase inhibitors ( PP1 and PP2 ) partially removed resistance but did not significantly inhibit Bcr-Abl tyrosine kinase activity ... In contrast, dasatinib, a dual Bcr-Abl and Src kinase inhibitor, inhibited the phosphorylation of both BCR-ABL and Lyn, and induced apoptosis of the Bcr-Abl cell line overexpressing p53/56 Lyn ... In contrast, dasatinib, a dual Bcr-Abl and Src kinase inhibitor, inhibited the phosphorylation of both BCR-ABL and Lyn, and induced apoptosis of the Bcr-Abl cell line overexpressing p53/56 Lyn ... In contrast, dasatinib, a dual Bcr-Abl and Src kinase inhibitor, inhibited the phosphorylation of both BCR-ABL and Lyn, and induced apoptosis of the Bcr-Abl cell line overexpressing p53/56 Lyn
Gobessi et al., Leukemia 2009 (Leukemia, Lymphocytic, Chronic, B-Cell) : In addition, R406 prevented the increase in leukemic cell viability induced by sustained BCR engagement and inhibited BCR induced Akt activation and Mcl-1 upregulation ... In addition, R406 prevented the increase in leukemic cell viability induced by sustained BCR engagement and inhibited BCR induced Akt activation and Mcl-1 upregulation
Gao et al., J Biol Chem 2009 : Here we identify the transcription factors that drive redox- and BCR-ABL1 dependent Fyn expression ... Our work is the first to define transcription factors that are responsible for endogenous, oxidative stress dependent and BCR-ABL1 dependent Fyn expression
Järås et al., Exp Hematol 2009 : By using a lentiviral anti-signal transducer and activator of transcription 5 ( STAT5 ) short-hairpin RNA, we found that both P190 BCR/ABL1- and P210 BCR/ABL1 induced erythroid cell expansion were STAT5 dependent
Schuman et al., Blood 2009 : However, the role of TAK1 in B-cell receptor (BCR) mediated NF-kappaB activation and B-cell development is not clear ... Thus, TAK1 is critical for B-cell maturation and BCR induced NF-kappaB activation
Jacobson et al., Mol Immunol 2009 : Prolonged activation of B cells via cross linking of the BCR ( but not CR1/CR2 alone ) leads to increased expression of Pcp4 and suppressed Ca ( 2+ ) release
Hodson et al., Adv Exp Med Biol 2009 : Although CD40, TLR and cytokines all activate PI3K the BCR seems especially dependent upon PI3K signalling
Mancini et al., Traffic 2009 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : In particular, constitutive tyrosine kinase ( TK ) activity of p210 BCR-ABL blocks c-Jun N-terminal kinase (JNK) phosphorylation leading to 14-3-3 sigma phosphorylation at a critical residue ( Ser ( 186 ) ) for c-ABL binding in response to DNA damage
Hirano et al., J Biol Chem 2009 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : The Abl kinase inhibitors and depletion of Bcr-Abl induced the expression of PHLPP1 and PHLPP2, which dephosphorylated Ser-473 on Akt1, -2, and -3, resulting in inhibited proliferation of CML cells ... The Abl kinase inhibitors and depletion of Bcr-Abl induced the expression of PHLPP1 and PHLPP2 , which dephosphorylated Ser-473 on Akt1, -2, and -3, resulting in inhibited proliferation of CML cells ... Thus, Bcr-Abl represses the expression of PHLPP1 and PHLPP2 and continuously activates Akt1, -2, and -3 via phosphorylation on Ser-473, resulting in the proliferation of CML cells ... Thus, Bcr-Abl represses the expression of PHLPP1 and PHLPP2 and continuously activates Akt1, -2, and -3 via phosphorylation on Ser-473, resulting in the proliferation of CML cells ... Thus, Bcr-Abl represses the expression of PHLPP1 and PHLPP2 and continuously activates Akt1 , -2, and -3 via phosphorylation on Ser-473, resulting in the proliferation of CML cells
Henry et al., J Immunol 2009 (Calcium Signaling) : These include BCR down-regulation, impaired proliferative responses to anti-CD40 , and diminished calcium mobilization upon stimulation with BCR dependent and independent stimuli
Geahlen et al., Biochim Biophys Acta 2009 : The B cell receptor (BCR) transduces antigen binding into alterations in the activity of intracellular signaling pathways through its ability to recruit and activate the cytoplasmic protein-tyrosine kinase Syk
Gross et al., J Immunol 2009 : Wild-type mature follicular B cells were less sensitive to BCR stimulation than were immature transitional stage 1 B cells with regard to BCR induced calcium elevation and ERK MAPK activation ... Wild-type mature follicular B cells were less sensitive to BCR stimulation than were immature transitional stage 1 B cells with regard to BCR induced calcium elevation and ERK MAPK activation
Li et al., J Int Med Res 2009 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : Studies have shown that vascular endothelial growth factor ( VEGF ), a major and potent inducer of angiogenesis, is directly triggered by the disease related oncogene Bcr-Abl in Bcr-Abl positive cells
Quiroga et al., Blood 2009 (Leukemia, Lymphocytic, Chronic, B-Cell) : Finally, R406 inhibited constitutive and BCR induced activation of Syk , extracellular signal regulated kinases, and AKT, and blocked BCR induced calcium mobilization ... Finally, R406 inhibited constitutive and BCR induced activation of Syk, extracellular signal regulated kinases, and AKT , and blocked BCR induced calcium mobilization
Baudot et al., Oncogene 2009 (Leukemia, Lymphocytic, Chronic, B-Cell) : Recent evidence pointing to a critical role of spleen tyrosine kinase (Syk) in ligand independent BCR signaling prompted us to examine its role in primary B-CLL cell survival
Jackson et al., J Immunol 2009 (Hypersensitivity) : To begin to understand physiologic determinants of CD23 expression, we analyzed effects of BCR and TLR stimulation on CD23 levels
Vlad et al., Cancer Res 2009 (Disease Progression...) : BCR stimulation promoted a strictly simultaneous down-regulation of CXCR4 and CD62L membrane expression to a variable extent ... BCR stimulation promoted a strictly simultaneous down-regulation of CXCR4 and CD62L membrane expression to a variable extent ... Functionally, cells down regulating CXCR4 and CD62L in response to BCR engagement displayed a reduction in both migration toward CXCL12 and adhesion to lymphatic endothelial cells ... Functionally, cells down regulating CXCR4 and CD62L in response to BCR engagement displayed a reduction in both migration toward CXCL12 and adhesion to lymphatic endothelial cells
Haas et al., J Immunol 2009 : Reducing CD19 expression in CD21/35 ( -/- ) mice normalized BCR induced calcium responses, PD-1 induction, and PPS-3-specific IgG3 responses and restored protection during S. pneumoniae infection
Oak et al., Autoimmunity 2009 : BCR mediated AKT phosphorylation is partially reduced in p85alpha-deficient B cells and further diminished with concomitant loss of p85beta
Hoek et al., J Immunol 2009 (Lymphopenia) : Recent studies have shown that BCR signaling positively regulates NF-kappaB2 , suggesting BCR regulation of BR3 signaling
Durand et al., J Immunol 2009 : In these innate-like B cells, p110delta activity mediates BCR- , TLR- and chemoattractant induced activation of the Akt prosurvival kinase, chemoattractant induced migration, and TLR induced proliferation
Juszczynski et al., Blood 2009 (Lymphoma, Large B-Cell, Diffuse) : Herein, we evaluated potential connections between BCL6 mediated transcriptional repression and SYK dependent BCR signaling
Donato et al., Biochem Pharmacol 2010 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : Aurora and BCR-ABL kinase inhibition were consistently measured at 20-100 nM and 2-10 microM MK-0457, respectively, but expression of T315I-BCR-ABL and overexpression of Lyn kinase reduced MK-0457 sensitivity
Richards et al., Eur J Immunol 2009 : BCR ligation leads to a more rapid decrease in p27 ( Kip1 ) levels in gp91(phox) KO B cells
Takemura et al., J Biol Chem 2010 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : Thus, Bcr-Abl represses the expression of RKIP, continuously activates pERK1/2, and suppresses FoxM1 expression, resulting in proliferation of CML cells ... Thus, Bcr-Abl represses the expression of RKIP , continuously activates pERK1/2, and suppresses FoxM1 expression, resulting in proliferation of CML cells ... Thus, Bcr-Abl represses the expression of RKIP, continuously activates pERK1/2 , and suppresses FoxM1 expression, resulting in proliferation of CML cells
Preisinger et al., Cell Signal 2010 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : The binding of GADS to Bcr-Abl requires Bcr-Abl tyrosine kinase activity and is sensitive to the Bcr-Abl inhibitor imatinib, while the GADS/Slp-76 and Slp-76/Nck interactions are tyrosine phosphorylation independent ... The binding of GADS to Bcr-Abl requires Bcr-Abl tyrosine kinase activity and is sensitive to the Bcr-Abl inhibitor imatinib, while the GADS/Slp-76 and Slp-76/Nck interactions are tyrosine phosphorylation independent
Ishiura et al., Eur J Immunol 2010 (Lymphoma, B-Cell) : BCR engagement induced differential tyrosine phosphorylation, as CD19-Y ( 513 ) phophorylation occurred first, and CD19-Y ( 482 ) phosphorylation was delayed and transient ... Different BCR isotypes exhibited distinct patterns of CD19 phosphorylation : IgG-BCR ligation resulted in faster phosphorylation of CD19-Y ( 513 ) and more intense phosphorylation of CD19-Y ( 391 ) than IgM-BCR ligation
Gleixner et al., Cancer Res 2010 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : Inhibition of BCR/ABL by imatinib or nilotinib ( AMN107 ) led to decreased expression of the Plk1 protein in CML cells, suggesting that BCR/ABL promotes Plk1 generation
Chu et al., Leukemia 2010 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : These studies show the importance of BCR-ABL-Y177-AKT mediated p27 phosphorylation in altered p27 localization and enhanced proliferation and expansion of primary CML progenitors
Malin et al., Curr Opin Immunol 2010 (Precursor Cell Lymphoblastic Leukemia-Lymphoma) : STAT5 also plays a key role in the generation of B cell precursor acute lymphoblastic leukemia, whereby the BCR-ABL1 translocation or the collaboration of JAK2 mutations with overexpression of the thymic stromal lymphopoietin receptor CRLF2 results in constitutive STAT5 activation leading to cytokine independent survival and growth of leukemic cells
Vidovic et al., Leukemia 2010 (Leukemia) : In this study, we show that overexpression of BCR/ABL1 in CD34+ progenitor cells leads to reduced expression of interferon regulatory factor 8 (IRF8) , in addition to increased WT1 expression
Hagn et al., Eur J Immunol 2010 (Lupus Erythematosus, Systemic) : IL-21 directly induced GzmB expression and secretion by CD5 ( + ) B cells from several AD and from cord blood in vitro, and the simultaneous presence of BCR stimulation strongly enhanced this process
Wolanin et al., Mol Cancer Ther 2010 (Aneuploidy...) : Bcr-Abl leads to decreased expression of genes involved in the mitotic checkpoint activation -- Mad2, Bub1 , Bub3, and BubR1, resulting in mitosis perturbances, weakened mitotic checkpoint function, and mitotic slippage after nocodazole treatment ... Bcr-Abl leads to decreased expression of genes involved in the mitotic checkpoint activation -- Mad2, Bub1, Bub3 , and BubR1, resulting in mitosis perturbances, weakened mitotic checkpoint function, and mitotic slippage after nocodazole treatment
Pene-Dumitrescu et al., J Biol Chem 2010 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : NaPP1 also reduced Hck mediated phosphorylation of Bcr-Abl at sites that may affect imatinib sensitivity exclusively in cells expressing Hck-T338A ... NaPP1 also reduced Hck mediated phosphorylation of Bcr-Abl at sites that may affect imatinib sensitivity exclusively in cells expressing Hck-T338A
Honigberg et al., Proc Natl Acad Sci U S A 2010 (Arthritis, Experimental...) : The Bruton tyrosine kinase (Btk) is specifically required for BCR signaling as demonstrated by human and mouse mutations that disrupt Btk function and prevent B-cell maturation at steps that require a functional BCR pathway
Sugalski et al., J Immunol 2010 (Hepatitis C...) : We observed intact or enhanced tetanus-specific and total IgG ASC frequency, serum IgG, BCR- and CD40L dependent CD80/CD86 expression, and CD40L dependent bulk B cell activation of memory CD4 cells in HCV infection
Ramadani et al., Science signaling 2010 : Unlike p110delta, however, p110alpha did not contribute to agonist induced BCR signaling
Rowland et al., J Immunol 2010 : Additionally, we show that BAFF is essential for the differentiation of CD23 ( - ) into CD23 ( + ) transitional B cells both in vitro and in vivo through a mechanism distinct from that mediating cell survival, but requiring tonic BCR signaling
Oh et al., J Neurosci 2010 (Synaptic Transmission) : Regulation of synaptic Rac1 activity, long-term potentiation maintenance, and learning and memory by BCR and ABR Rac GTPase activating proteins ... These results suggest that BCR and ABR have novel roles in the regulation of synaptic Rac1 signaling, synaptic plasticity, and learning and memory, and that excessive Rac1 activity negatively affects synaptic and cognitive functions
Modi et al., Leukemia 2011 (Cell Transformation, Neoplastic...) : We conclude that inhibition of Grb2 expression demonstrates an important role in BCR-ABL mediated MAPK activation and transformation of primary human hematopoietic cells.These results support further investigation of downstream effectors of Grb2 mediated signals and targeting of Grb2 interactions in the treatment of CML
Ying et al., Immunobiology 2011 : It has been shown that CD40 stimulation can augment BCR induced B cell responses, but the molecular mechanism ( s ) by which CD40 regulates BCR signaling is poorly understood
Kelly et al., J Cell Mol Med 2011 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : In contrast to other Aurora kinase inhibitors, MLN8237 did not significantly affect BCR-ABL activity
Thai et al., Leukemia 2011 (Cell Transformation, Neoplastic...) : We resolve this paradox, demonstrating that BCR-ABL1 kinase activity is regulated by RIN1 , an ABL SH3/SH2 binding protein
Mao et al., Proc Natl Acad Sci U S A 2010 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : As4S4 targets RING-type E3 ligase c-CBL to induce degradation of BCR-ABL in chronic myelogenous leukemia
Slupianek et al., Cancer Res 2011 (Chromosome Aberrations...) : Here, we show that BCR/ABL enhances the expression and increase nuclear localization of WRN ( mutated in Werner syndrome ), which is required for processing DSB ends during the repair
Clark et al., Mol Immunol 2011 : However, it has become increasingly apparent that the BCR also directs the translocation of MHC class II and TLR9 into the MIIC and that the endocytic flow of these receptors coincides with that of the BCR ... However, it has become increasingly apparent that the BCR also directs the translocation of MHC class II and TLR9 into the MIIC and that the endocytic flow of these receptors coincides with that of the BCR
Sun et al., Blood 2011 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : WP1130, but not Bcr-Abl kinase inhibitors, directly inhibits Usp9x deubiquitinase activity, resulting in the down-regulation of the prosurvival protein Mcl-1 and facilitating apoptosis
Yi et al., BMC biochemistry 2011 : Transglutaminase 2 (TG2) regulates Bcr by direct binding to its GAP domain
Allan et al., J Immunol 2011 : However, BCR induced upregulation of CD1c was independent of the RAR pathway
Salas et al., Blood 2011 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2A ... Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2A ... We show herein that increased SK-1/S1P enhances Bcr-Abl1 protein stability, through inhibition of its proteasomal degradation in imatinib-resistant K562/IMA-3 and LAMA-4/IMA human CML cells ... Regulation of Bcr-Abl1 by SK-1/S1P was dependent on S1P receptor 2 (S1P2) signaling, which prevented Bcr-Abl1 dephosphorylation, and degradation via inhibition of PP2A ... Regulation of Bcr-Abl1 by SK-1/S1P was dependent on S1P receptor 2 (S1P2) signaling, which prevented Bcr-Abl1 dephosphorylation, and degradation via inhibition of PP2A ... Since SK-1/S1P/S1P2 signaling regulates Bcr-Abl1 stability via modulation of PP2A, inhibition of SK-1/S1P2 axis represents a novel approach to target wild-type- or mutant-Bcr-Abl1 thereby overcoming drug resistance ... Since SK-1/S1P/S1P2 signaling regulates Bcr-Abl1 stability via modulation of PP2A, inhibition of SK-1/S1P2 axis represents a novel approach to target wild-type- or mutant-Bcr-Abl1 thereby overcoming drug resistance ... Since SK-1/S1P/S1P2 signaling regulates Bcr-Abl1 stability via modulation of PP2A, inhibition of SK-1/S1P2 axis represents a novel approach to target wild-type- or mutant-Bcr-Abl1 thereby overcoming drug resistance
Kometani et al., J Exp Med 2011 : These mice had impaired T cell independent type II antibody responses in vivo and diminished IKK-ß activation and cellular responses to B cell receptor (BCR) cross linking in vitro
Sheng et al., Blood 2011 (Cell Transformation, Neoplastic...) : We find that BCR-ABL , through PI3K/AKT/FOXO4 signaling, transcriptionally up-regulates ATF5 expression and that ATF5, in turn, stimulates transcription of mammalian target of rapamycin ( mTOR ; also called mechanistic target of rapamycin ), a well established master negative-regulator of autophagy
Sohn et al., Blood 2011 : In the present study, we provide evidence that the expression of FcRL4 in human B-cell lines disrupts immune synapse formation and blocks antigen induced BCR signaling at the point of Syk phosphorylation, blocking downstream activation of PLC-?2 and Vav and the induction of calcium responses and CD69 expression
Gross et al., Eur J Immunol 2011 : The Src-family tyrosine kinase Lyn negatively regulates BCR signaling and also myeloid cell activity
Yang et al., J Cell Physiol 2011 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : Promoter deletion and mutation analysis indicate the Tcf-4/ß-catenin and STAT1 binding sites located between the -405/-223 region of the human Jab1 promoter are important for the activation of Jab1 by Bcr-Abl ... Our results also demonstrate that the AKT signaling pathway is involved in the regulation of Jab1 by Bcr-Abl because the AKT inhibitor LY294002 but not the ERK inhibitor PD98059 reduces Jab1 promoter activity and mRNA expression
Chaturvedi et al., Nat Immunol 2011 : Binding of antigen to the B cell antigen receptor (BCR) triggers both BCR signaling and endocytosis
Tabe et al., Leukemia 2012 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : Src related kinase Lyn is known to interact with CXCL12/CXCR4 signaling and is directly activated by p210 Bcr-Abl
Singh et al., Cancer 2012 (Blast Crisis...) : BCR-ABL1 expression up-regulated HO-1 , a survival factor for CML cells
Yuan et al., Blood 2012 (Cell Transformation, Neoplastic...) : Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesis ... In the present study, we show that BCR-ABL activates the expression of the mammalian stress response gene SIRT1 in hematopoietic progenitor cells and that this involves STAT5 signaling ... In the present study, we show that BCR-ABL activates the expression of the mammalian stress response gene SIRT1 in hematopoietic progenitor cells and that this involves STAT5 signaling ... Imatinib mediated inhibition of BCR-ABL kinase activity partially reduces SIRT1 expression and SIRT1 inhibition further sensitizes CML cells to imatinib induced apoptosis
Tschiedel et al., Leukemia & lymphoma 2012 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : Furthermore, the Bcr-Abl dependent overexpression of NME2 protein was reversed specifically by tyrosine kinase inhibitor ( TKI ) treatment of Ba/F3 expressing wild-type and TKI-sensitive, but not TKI-resistant, mutants of Bcr-Abl
Colombo et al., PloS one 2012 (Lupus Erythematosus, Systemic...) : The effect of LAIR1 ligation by specific monoclonal antibodies, collagen or collagen producing mesenchymal stromal cells from reactive lymph nodes or bone marrow on Ig production by pokeweed mitogen and B cell receptor (BCR) mediated NF-kB activation was assessed by ELISA and TransAM assay
Pillai et al., Leukemia & lymphoma 2012 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : In parallel, 8-amino-Ado inhibited RNA synthesis and resulted in a depletion of BCR-ABL transcript
Katkere et al., J Biol Chem 2012 : This study establishes that downstream Syk dependent BCR signaling is also required for BCR ubiquitination and BCR mediated antigen processing and presentation
Iwata et al., J Allergy Clin Immunol 2012 : Syk mediated BCR signaling is a prerequisite for optimal induction of TLR9 and TRAF6, allowing efficient propagation of TLR9 mediated signaling in memory B cells
Kuroda et al., Oncogene 2013 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive...) : These observations demonstrate that BCR-ABL is critically involved in the leukemia-specific expression of DR4 and DR5 and in the susceptibility of Ph ( + ) leukemia to TRAIL mediated anti-leukemic activity, providing new insight into the mechanisms of the tumor-specific cytotoxic activities of TRAIL
Maruyama et al., J Biol Chem 2012 : Despite its importance in the TCRs and BCR activated TRAF6 inhibition , the involvement of TANK in RANKL signaling is poorly understood
Xu et al., Immunol Cell Biol 2012 : To understand the mechanisms of PI3K regulation during B-cell activation, we performed a series of biochemical analysis on primary B cells, and found that activity of Src family tyrosine kinases (SFK) is crucial for the activation of PI3K following BCR ligation and this is regulated by the SFK Lyn
Qiu et al., Neoplasia (New York, N.Y.) 2012 (Cell Transformation, Neoplastic...) : Here, we demonstrate that coexpression of Bcr-Abl with SOCS-1 or SOCS-3 results in tyrosine phosphorylation of these SOCS proteins ... Bcr-Abl dependent tyrosine phosphorylation of SOCS-1 and SOCS-3 occurs mainly on Tyr 155 and Tyr 204 residues of SOCS-1 and on Tyr 221 residue of SOCS-3 ... Bcr-Abl dependent tyrosine phosphorylation of SOCS-1 and SOCS-3 occurs mainly on Tyr 155 and Tyr 204 residues of SOCS-1 and on Tyr 221 residue of SOCS-3
Liu et al., Science signaling 2012 : Knocking down SAP97 in IgG? B cells or mutating the putative PDZ binding motif in the BCR tail impaired formation of the immunological synapse, initiation of IgG BCR signaling, and downstream activation of the mitogen activated protein kinase p38
Casolari et al., Leukemia 2013 (Blast Crisis...) : Transient BCR-ABL expression led to significant reduction in BACH2 promoter activity and this effect was dependent on the kinase function of the oncoprotein
Kawano et al., Mol Cell Biol 2012 : Here we demonstrate that the pre-BCR signal induces the expression of lysosome associated protein transmembrane 5 ( LAPTM5 ), which leads to the prompt downmodulation of the pre-BCR
Blix et al., BMC cancer 2012 (Leukemia, Lymphocytic, Chronic, B-Cell...) : Impaired anti-BCR induced p-PLC? was associated with reduced surface expression of IgM and CD79b
Schickel et al., EMBO Mol Med 2012 : Carabin deficiency in B cells increases BCR-TLR9 costimulation induced autoimmunity
Raghunandan et al., Scand J Immunol 2013 : Stimulation through the BCR results in time dependent inhibition of Ets-1 mRNA expression in primary splenic B cells with maximal inhibition observed by 16-h post-stimulation
Hsu et al., Immunol Lett 2013 (Arthritis, Rheumatoid...) : BTK is also an essential effector of B cell receptor (BCR) induced B cell signaling
Bergmann et al., J Exp Med 2013 : B cell survival, surface BCR and BAFFR expression, CD74 metabolism, and CD8- dendritic cells require the intramembrane endopeptidase SPPL2A
Mukherjee et al., Science signaling 2013 : In contrast, when B cells were stimulated by monomeric ligands that failed to produce BCR clustering, both Syk and SFKs were required for complete and rapid BCR activation
Liu et al., Leuk Res 2013 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : In K562 leukemia cells, overexpression of miR-30a reduced ABL1 and BCR-ABL1 protein expression, decreased proliferation, and arrested cell cycle progression between G1 and S
Boukhiar et al., Experimental hematology & oncology 2013 : BCR engagement resulted in an increase of LYN phosphorylation leading to activation of c-JUN NH2-terminal kinase (JNK) and over-expression of the early growth response gene-1 (EGR-1) ... Inhibition of JNK with SP600125 induced apoptosis and reduced level of basal and BCR induced expression of EGR-1 ... Treatment with PP2 or with dasatinib suppressed BCR induced LYN and JNK phosphorylation as well as EGR-1 upregulation and is associated with a decrease of cell survival in all cases analysed ... Treatment with PP2 or with dasatinib suppressed BCR induced LYN and JNK phosphorylation as well as EGR-1 upregulation and is associated with a decrease of cell survival in all cases analysed
Schweighoffer et al., Immunity 2013 : Surprisingly, BAFFR signaling directly induced phosphorylation of both Syk and the BCR associated Iga signaling subunit, and this Syk phosphorylation required the BCR ... Surprisingly, BAFFR signaling directly induced phosphorylation of both Syk and the BCR associated Iga signaling subunit, and this Syk phosphorylation required the BCR
Harvey et al., BioDrugs 2013 (Lupus Erythematosus, Systemic) : Epratuzumab is a humanized monoclonal antibody that targets CD22 on B cells and results in modulation of B-cell function and migration, as CD22 regulates adhesion and inhibits B-cell receptor (BCR) signalling
Taniguchi et al., PloS one 2013 : Here, we present data indicating that the increase in intracellular zinc level induced by ZIP9/SLC39A9 ( a ZIP Zrt-/Irt-like protein ) plays an important role in the activation of Akt and Erk in response to BCR activation ... Here, we present data indicating that the increase in intracellular zinc level induced by ZIP9/SLC39A9 ( a ZIP Zrt-/Irt-like protein ) plays an important role in the activation of Akt and Erk in response to BCR activation
Burin et al., Basic Clin Pharmacol Toxicol 2013 : In this investigation, Bothrops pirajai L-amino acid oxidase ( BpirLAAO-I ) effect on normal peripheral blood mononuclear cells ( PBMC ) and on BCR-ABL ( + ) cell line was assessed to explore its potential against leukaemic cells
Xu et al., J Immunol 2013 (Autoimmune Diseases...) : We further demonstrated that Cd72(c) is a hypofunctional allele in BCR signal inhibition and that CD72 deficiency induces severe autoimmune disease in the presence of Fas ( lpr )
Uhde et al., Int Immunol 2013 : Neither wild type nor CD83 transgenic (CD83tg) B cells produced any IL-10 in response to BCR stimulation ... BCR engagement led to reduced activation of LYN, SYK and ERK1/2 resulting in reduced numbers of proliferating cells in all CD83tg B cell subsets ... BCR engagement led to reduced activation of LYN, SYK and ERK1/2 resulting in reduced numbers of proliferating cells in all CD83tg B cell subsets ... BCR engagement led to reduced activation of LYN , SYK and ERK1/2 resulting in reduced numbers of proliferating cells in all CD83tg B cell subsets
Liu et al., PloS one 2013 : A low level of expression of miR-196b can cause up-regulation of BCR-ABL1 and HOXA9 expression, which leads to the development of chronic myeloid leukemia
Day et al., Endocrinology 1988 (Pituitary Neoplasms) : Both TRH- and vasoactive intestinal peptide stimulated PRL release were inhibited to basal levels by 10 nM BCR , with an IC50 for BCR of approximately 0.25 nM ... Both TRH- and vasoactive intestinal peptide stimulated PRL release were inhibited to basal levels by 10 nM BCR , with an IC50 for BCR of approximately 0.25 nM
Notter et al., J Anim Sci 1988 : Effects of CRG on BCR and CD were small at high values of CRG, but these effects increased as CRG declined
Elson et al., Immunology 1981 : This Igb anti-Iga response was profoundly suppressed by injecting lymphoid cells from congenic Iga mice but not by serum Iga
Maru et al., Mol Cell Biol 1995 (Cell Transformation, Neoplastic) : Tyrosine phosphorylation of BCR by FPS/FES protein-tyrosine kinases induces association of BCR with GRB-2/SOS ... Tyrosine phosphorylation of BCR by FPS/FES protein-tyrosine kinases induces association of BCR with GRB-2/SOS ... Coexpression of BCR with the cytoplasmic protein-tyrosine kinase encoded by the c-fes proto-oncogene in Sf-9 cells resulted in stable BCR-FES protein complex formation and tyrosine phosphorylation of BCR ... Tyrosine phosphorylation of BCR in v-fps transformed cells induced its association with GRB-2/SOS , the RAS guanine nucleotide exchange factor complex ... Tyrosine phosphorylation of BCR in v-fps transformed cells induced its association with GRB-2/SOS , the RAS guanine nucleotide exchange factor complex
Harrison-Findik et al., Oncogene 1995 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : P210 BCR/abl tyrosine kinase induces tyrosine phosphorylation of Shc , and activation of p21ras and PI 3-Kinase ... P210 BCR/abl tyrosine kinase induces tyrosine phosphorylation of Shc, and activation of p21ras and PI 3-Kinase ... P210 BCR/abl tyrosine kinase induces tyrosine phosphorylation of Shc, and activation of p21ras and PI 3-Kinase
Takata et al., FEBS Lett 1995 : These results demonstrate that the BCR induced phosphorylation of Src-PTK is independent of Syk and that the kinase activity of Src-PTK is critical for BCR signaling ... These results demonstrate that the BCR induced phosphorylation of Src-PTK is independent of Syk and that the kinase activity of Src-PTK is critical for BCR signaling
Skorski et al., Blood 1995 (Blast Crisis...) : Phosphatidylinositol-3 kinase activity is regulated by BCR/ABL and is required for the growth of Philadelphia chromosome positive cells
Hata et al., Mol Cell Biol 1994 : To investigate the role of Csk in BCR signaling, Csk negative chicken B-cell clones were generated
Ernst et al., J Biol Chem 1994 : p210Bcr/Abl and p160v-Abl induce an increase in the tyrosine phosphorylation of p93c-Fes
Galibert et al., J Exp Med 1996 : CD40 + BCR stimulation of resting B cells with CD40 ligand transfected fibroblastic cells in the presence of cross linked anti-BCR monoclonal antibodies resulted in the coexpression of CD38, CD95 , and CPM ... CD40 + BCR stimulation of resting B cells with CD40 ligand transfected fibroblastic cells in the presence of cross linked anti-BCR monoclonal antibodies resulted in the coexpression of CD38 , CD95, and CPM ... CD40 + BCR stimulation of resting B cells with CD40 ligand transfected fibroblastic cells in the presence of cross linked anti-BCR monoclonal antibodies resulted in the coexpression of CD38, CD95, and CPM
Luisiri et al., J Biol Chem 1996 : The enhancement of Ig-alpha phosphorylation by Ig-beta correlated with a lowering of the stimulation threshold for tyrosine kinase activation
Maltzman et al., Mol Cell Biol 1996 (Lymphoma, B-Cell) : BCR induced increases in CD44 mRNA expression and transcription levels are shown to occur in EGR1 expressing but not in nonexpressing subclones of the B-cell line WEHI-231
Kawauchi et al., Mol Immunol 1996 : Ligation of the B cell Ag receptor (BCR) activates a protein-tyrosine kinase ( PTK ) and CD45 protein-tyrosine phosphatase ( PTPase ) -dependent signaling cascade that results in the activation of Ras
Maltzman et al., J Exp Med 1996 : ICAM-1 expression is upregulated as a consequence of B lymphocyte antigen receptor (BCR) signaling, thereby serving to render antigen stimulated B cells more receptive to T cell mediated costimulatory signals ... We have investigated BCR induced expression of the Icam-1 gene in primary B cells and B cell lines and have found it to be dependent on BCR induced expression of the transcription factor EGR1
Neumann et al., Anticancer Res 1996 (Leukemia, Megakaryoblastic, Acute) : A human myeloid cell line, Mo7, and a daughter cell line expressing the bcr/abl oncogene, Mo7-P210, were used in a comparative study analyzing the effects of p210BCR/ABL expression on tyrosine phosphorylation, specific DNA binding and expression of the proto-oncoprotein c-Rel
Smit et al., Oncogene 1996 (Burkitt Lymphoma) : B-cell antigen receptor (BCR) stimulation induces tyrosine phosphorylation of the Shc adaptor protein and its association with Grb2 ... B-cell antigen receptor (BCR) stimulation induces tyrosine phosphorylation of the Shc adaptor protein and its association with Grb2 ... We reveal here an additional complexity of the BCR induced Shc/Grb2 complex : it contains tyrosine phosphorylated proteins of 130, 110 and 75 kDa
Lund et al., J Immunol 1996 (Lymphoma, B-Cell) : Together, these data demonstrate that the CD38 molecule can influence BCR induced responses and that CD38 signaling is dependent on the BCR complex , perhaps to utilize a functional cytoplasmic tail ( s ) for intracellular signaling
Jain et al., Blood 1996 : PI 3-kinase activation in BCR/abl transformed hematopoietic cells does not require interaction of p85 SH2 domains with p210 BCR/abl ... Despite lack of direct interaction with p85 SH2 domains, expression of ts p210 BCR/abl resulted in rapid, time dependent activation of total and membrane associated PI 3-kinase and increased PI 3-kinase activity in anti-P-tyr and anti-abl immunoprecipitates ... These data suggest that BCR/abl induced activation of PI 3-kinase in hematopoietic cells does not require binding of p85 SH2 domains to BCR/abl gene product and involves interaction with other tyrosine phosphorylated intermediate proteins
Salgia et al., J Biol Chem 1996 (Cell Transformation, Neoplastic) : In both normal and BCR/ABL transformed cells, p130 ( CAS ) was detected in focal adhesion-like structures, as was BCR/ABL
Sutherland et al., J Immunol 1996 : We found that BCR engagement in WEHI-231 cells caused a 15- to 20-fold activation of ERK2 and a 2- to 3-fold stimulation of ERK1 ... In summary, the BCR strongly activates ERK2 and weakly activates ERK1, JNK, and p38 , while CD40 markedly stimulates the JNK and p38 kinases ... In summary, the BCR strongly activates ERK2 and weakly activates ERK1 , JNK, and p38, while CD40 markedly stimulates the JNK and p38 kinases
Ingham et al., J Biol Chem 1996 : We show that engaging the B cell antigen receptor (BCR) on the RAMOS B cell line caused both Crk-L and Crk II to associate with several tyrosine phosphorylated proteins ... We show that engaging the B cell antigen receptor (BCR) on the RAMOS B cell line caused both Crk-L and Crk II to associate with several tyrosine phosphorylated proteins
Einat et al., Leuk Res 1996 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : A decrease in BCR/ABL fusion product was observed ( by FISH analysis ) after incubation of BM cells from CML patients in liquid culture for 7 days with 10 ( -9 ) M ARA-C or 10 ( -7 ) M Eilatin in the presence of IL-11 alone or in combination with other cytokines
Li et al., J Biol Chem 1996 : Mutagenesis of BCR Tyr-177 to Phe completely abolished FES induced BCR binding to the GRB2 SH2 domain, identifying Tyr-177 as an additional phosphorylation site for FES ... By contrast, tyrosine phosphorylation of BCR by FES suppressed BCR serine/threonine kinase activity toward the 14-3-3 protein and BCR substrate, BAP-1
Rozsnyay et al., Immunol Lett 1996 : Here we studied the potential involvement of ezrin in the B-cell receptor (BCR) signaling in BL41 Burkitt lymphoma cells
Pao et al., J Immunol 1997 : CD45 expression is required for BCR triggering of certain of these downstream events, such as calcium mobilization and p21ras activation
Wang et al., J Exp Med 1996 : Compared with control B cells, Lyn-/- B cells were hyper responsive to anti-IgM induced proliferation and defective in Fc gamma RIIB mediated suppression of B cell antigen receptor (BCR) signaling, indicating that Lyn is involved in the negative regulation of BCR signaling ... Compared with control B cells, Lyn-/- B cells were hyper responsive to anti-IgM induced proliferation and defective in Fc gamma RIIB mediated suppression of B cell antigen receptor (BCR) signaling, indicating that Lyn is involved in the negative regulation of BCR signaling ... Moreover, BCR cross linking in Lyn-/- B cells suppressed Fas expression induced by costimulation with CD40 ligand and IL-4
Sánchez-García et al., J Mol Biol 1997 (Cell Transformation, Neoplastic...) : Regulation of Bcl-2 gene expression by BCR-ABL is mediated by Ras
Harmer et al., Mol Cell Biol 1997 : Cross linking of the B-cell antigen receptor (BCR) induces tyrosine phosphorylation of Shc , which is believed to lead to the activation of Ras
Wilson-Rawls et al., Leukemia 1997 : P210 Bcr-Abl interacts with the interleukin-3 beta c subunit and constitutively activates Jak2
Li et al., J Biol Chem 1997 : Syk is required for BCR mediated activation of p90Rsk , but not p70S6k, via a mitogen activated protein kinase independent pathway in B cells ... Syk is required for BCR mediated activation of p90Rsk, but not p70S6k , via a mitogen activated protein kinase independent pathway in B cells
Vuica et al., J Exp Med 1997 : The differential effects of BCR and BCR-FcgammaRIIB1 mediated signaling on the phosphorylation of GAP-A.p62 and its association with Csk suggest that docking of Csk to GAP-A.p62 may function in the negative regulation of antigen receptor mediated signals in B cells
Chan et al., Immunity 1997 : Lyn-deficient mice were generated to analyze the role of Lyn in B cell antigen receptor (BCR) signaling
Haataja et al., J Biol Chem 1997 : Rac3 is an active GTPase, and this activity is regulated by Bcr
McWhirter et al., Oncogene 1997 (Cell Transformation, Neoplastic) : Previous studies have demonstrated that both the Bcr and the Abl functional domains contribute to the oncogenic activity of Bcr-Abl proteins ... Previous studies have demonstrated that both the Bcr and the Abl functional domains contribute to the oncogenic activity of Bcr-Abl proteins
Sato et al., Proc Natl Acad Sci U S A 1997 : Ligation of CD19 and CD22 in vivo is likely to positively and negatively regulate BCR signaling, respectively, because CD19 crosslinking was more efficient than BCR crosslinking at inducing Vav phosphorylation ... Ligation of CD19 and CD22 in vivo is likely to positively and negatively regulate BCR signaling, respectively, because CD19 crosslinking was more efficient than BCR crosslinking at inducing Vav phosphorylation
Hamdane et al., Oncogene 1997 : Activation of p65 NF-kappaB protein by p210BCR-ABL in a myeloid cell line ( P210BCR-ABL activates p65 NF-kappaB ) ... We have analysed the effect of p210BCR-ABL expression on NF-kappaB activity in DA1 cells ( an IL-3 dependent murine myeloid progenitor cell line ) ... A specific stimulation of NF-kappaB activity by kinase-active wild-type p210BCR-ABL has been evidenced by transcriptional activation assays
Warmuth et al., J Biol Chem 1997 : Neither the complex formation of Hck kinase with Bcr-Abl nor the activation of Hck by Bcr-Abl was dependent on the Abl kinase activity ... Neither the complex formation of Hck kinase with Bcr-Abl nor the activation of Hck by Bcr-Abl was dependent on the Abl kinase activity
Genevier et al., Clin Exp Immunol 1997 (Agammaglobulinemia) : Impaired Ca2+ mobilization by X-linked agammaglobulinaemia ( XLA ) B cells in response to ligation of the B cell receptor (BCR)
Kitanaka et al., Blood 1998 (Agammaglobulinemia) : In surface immunoglobulin positive B cells ( Ramos ), ligation of the B-cell antigen receptor (BCR) with anti-IgM antibodies caused marked tyrosine phosphorylation of Tec and increased Tec tyrosine kinase activity
Ahmed et al., Oncogene 1998 : Our results indicate that although both constitutively activated cEpoR and BCR-ABL oncogenes induce growth-factor independence in Ba/F3 cells, only BCR-ABL is able to protect cells from etoposide and serum-deprivation induced apoptosis and induce a strong constitutive activation of STAT factors, suggesting a role for these molecules in the anti-apoptotic activity of BCR-ABL
Salmon et al., J Immunol 1997 : We conclude that the activation of p38 MAPK and MAPKAP kinase-2 by cross linking of the TCR, BCR , Fas, or CD40 was not correlated with their roles in regulating lymphocyte survival, and that suppression of kinase activity did not inhibit the induction of apoptosis ... We conclude that the activation of p38 MAPK and MAPKAP kinase-2 by cross linking of the TCR, BCR , Fas, or CD40 was not correlated with their roles in regulating lymphocyte survival, and that suppression of kinase activity did not inhibit the induction of apoptosis
Cornall et al., Immunity 1998 (Lupus Erythematosus, Systemic) : Lyn is not required to initiate B cell antigen receptor (BCR) signaling but is an essential inhibitory component
Bolland et al., Immunity 1998 : Conversely, increasing PIP3 levels by deletion of SHIP results in increased Btk association with the membrane and hyperresponsive BCR signaling
Adachi et al., J Immunol 1998 : Moreover, cross linking of B cell Ag receptor (BCR) enhances both tyrosine phosphorylation of CD72 and association of CD72 with SHP-1 in B cell line WEHI-231
Chan et al., Curr Biol 1998 : To elucidate the role of the Src family kinase Lyn in B cell receptor (BCR) signaling, we and others previously generated lyn-/- mice and analyzed their B cell responses ... Although the initiation of BCR signaling in lyn-/- B cells is delayed, BCR induced ERK2 activation and proliferation are enhanced
Dennehy et al., Eur J Immunol 1998 : Both c-cbl and ras GAP have been proposed to suppress receptor mediated signaling, and may contribute to CD5 mediated suppression of TCR or BCR signaling
Lens et al., J Immunol 1998 : Indeed, ligation of both Fas and BCR resulted in cleavage of the IL-1beta converting enzyme/Ced-3-like protease caspase 3 and its substrates Ac-Asp-Glu-Val-Asp-aldehyde and poly ( ADP-ribose ) polymerase
Graves et al., J Immunol 1998 (Lymphoma, B-Cell) : Both BCR- and Fas induced apoptosis are blocked by the peptide cysteine protease inhibitor benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone ( ZVAD ( mlz ) ), demonstrating a common requirement caspase activity ... To determine the role of p38 MAPK activation in BCR- and Fas induced apoptosis, we employed SB203580, a specific inhibitor of p38 MAPK ... To determine the role of p38 MAPK activation in BCR- and Fas induced apoptosis, we employed SB203580, a specific inhibitor of p38 MAPK
Selleri et al., Blood 1998 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive...) : Fas mediated modulation of Bcr/Abl in chronic myelogenous leukemia results in differential effects on apoptosis
Reiter et al., Blood 1998 (Myeloproliferative Disorders...) : We hypothesize that this fusion leads to constitutive activation of the FGFR1 tyrosine kinase in a manner analogous to the activation of ABL by BCR in chronic myeloid leukemia
Skorski et al., Proc Natl Acad Sci U S A 1998 (Leukemia, Experimental...) : We show here that the small GTP binding protein Rac is activated by BCR/ABL in a tyrosine kinase dependent manner
Hashimoto et al., J Exp Med 1998 : Here we demonstrate that the BCR induced ERK activation is reduced by loss of Grb2 or expression of a dominant negative form of Ras, RasN17, whereas this response is not affected by loss of Shc ... Similar to cooperation of Ras with PKC activation in ERK response, both PLC-gamma2 dependent signal and GTPase are required for BCR induced JNK and p38 responses
Jiang et al., J Exp Med 1998 : BCR cross linking in the chicken DT40 B cell line also activates three distinct mitogen activated protein kinases ( MAPKs ) : extracellular signal regulated kinase ( ERK ) 2, c-jun NH2-terminal kinase ( JNK ) 1, and p38 MAPK ... BCR mediated activation of ERK2, although maintained in Lyn-deficient cells, was abolished in Syk-deficient cells and partially inhibited in Btk-deficient cells, indicating that BCR mediated ERK2 activation requires Syk and that sustained ERK2 activation requires Btk ... BCR mediated activation of ERK2, although maintained in Lyn-deficient cells, was abolished in Syk-deficient cells and partially inhibited in Btk-deficient cells, indicating that BCR mediated ERK2 activation requires Syk and that sustained ERK2 activation requires Btk ... BCR mediated activation of ERK2, although maintained in Lyn-deficient cells, was abolished in Syk-deficient cells and partially inhibited in Btk-deficient cells, indicating that BCR mediated ERK2 activation requires Syk and that sustained ERK2 activation requires Btk ... However, BCR mediated p38 MAPK activation was abolished in Lyn/Syk double deficient cells, demonstrating that either Lyn or Syk alone may be sufficient to activate p38 MAPK ... However, BCR mediated p38 MAPK activation was abolished in Lyn/Syk double deficient cells, demonstrating that either Lyn or Syk alone may be sufficient to activate p38 MAPK
McLeod et al., J Biol Chem 1998 : In this report, we show that BCR engagement activates Rap1 and that this is dependent on production of diacylglycerol ( DAG ) by phospholipase C-gamma ... However, the DAG dependent pathway by which the BCR activates Rap1 apparently does not involve Crk signaling complexes since phorbol dibutyrate could activate Rap1 without inducing the formation of these complexes ... Thus, the BCR activates Rap1 via a novel DAG dependent pathway
Zhang et al., Blood 1998 (Cell Transformation, Neoplastic...) : Bcr-Abl efficiently induces a myeloproliferative disease and production of excess interleukin-3 and granulocyte-macrophage colony stimulating factor in mice : a novel model for chronic myelogenous leukemia ... Bcr-Abl efficiently induces a myeloproliferative disease and production of excess interleukin-3 and granulocyte-macrophage colony stimulating factor in mice : a novel model for chronic myelogenous leukemia
Mullins et al., Mol Immunol 1998 : Finally, CD40 mediated signals induce resting B cells to accumulate the CKI, p21, while cycling B cells require both BCR- and CD40 mediated signals to maintain increased expression of p21
Zhang et al., EMBO J 1998 : By monitoring the activation of signaling elements in pervanadate stimulated B cells expressing different levels of the BCR, we show here that phosphorylation of SLP-65 and Syk , but not of Lyn, is strictly dependent on the expression of the BCR on the cell surface ... By monitoring the activation of signaling elements in pervanadate stimulated B cells expressing different levels of the BCR, we show here that phosphorylation of SLP-65 and Syk, but not of Lyn, is strictly dependent on the expression of the BCR on the cell surface
Venkataraman et al., Mol Immunol 1998 : Previous studies have shown that PKA-activation blocks BCR induced phospholipase Cgamma-activation and calcium mobilization
Shi et al., Blood 1999 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : Either an oncogenic form of Ras or Bcr-Abl enhances GCKR catalytic activity and its activation of SAPK, whereas inhibition of GCKR impairs Bcr-Abl induced SAPK activation